Protein: WNK1
Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1)

Gene: WNK1
Organism: Homo sapiens
Interactions: 159
UniProt ID: Q9H4A3

Gene Ontology (top 5):
GO:0002028 - regulation of sodium ion transport
GO:0003084 - positive regulation of systemic arterial blood pressure
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

343644

OXSR1
Serine/threonine-protein kinase OSR1

4

20

Small-scale

0.909

High

1418959

WNK3
Serine/threonine-protein kinase WNK3

3

17

High-throughput

0.861

High

1433327

WNK2
Serine/threonine-protein kinase WNK2

2

18

High-throughput

0.817

High

725457

KAP1
cAMP-dependent protein kinase type I-beta regulatory subunit

2

13

High-throughput

0.793

High

1178789

AAK1
AP2-associated protein kinase 1

2

19

High-throughput

0.789

High

122976

SGK1
Serine/threonine-protein kinase Sgk1

2

17

Small-scale

0.754

High

242918

PRKN
E3 ubiquitin-protein ligase parkin

2

13

High-throughput

0.754

High

1394706

WNK4
Serine/threonine-protein kinase WNK4

2

18

Small-scale

0.754

High

730237

1433B
14-3-3 protein beta/alpha

6

20

High-throughput

0.730

High

1433320

KLHL3
Kelch-like protein 3

6

15

Small-scale

0.730

High

966868

1433G
14-3-3 protein gamma

5

20

High-throughput

0.718

High

537907

HSP7C
Heat shock cognate 71 kDa protein

5

8

High-throughput

0.712

High

521435

ARAF
Serine/threonine-protein kinase A-Raf

1

15

High-throughput

0.698

High

580836

PVR
Poliovirus receptor

1

3

High-throughput

0.698

High

1038355

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

19

High-throughput

0.698

High

1419617

GLIS2
Zinc finger protein GLIS2

1

5

Small-scale

0.698

High

1433306

WNK1
Serine/threonine-protein kinase WNK1

1

18

High-throughput

0.698

High

955590

CDC42
Cell division control protein 42 homolog

1

15

High-throughput

0.691

High

1092494

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

16

High-throughput

0.691

High

1391761

AURKB
Aurora kinase B

1

16

High-throughput

0.691

High

1408136

BAG1
BAG family molecular chaperone regulator 1

1

1

High-throughput

0.691

High

1433322

KS6A6
Ribosomal protein S6 kinase alpha-6

1

17

High-throughput

0.691

High

1433326

T22D4
TSC22 domain family protein 4

4

17

High-throughput

0.691

High

329106

KLHL2
Kelch-like protein 2

4

15

Small-scale

0.683

High

458482

ADRB2
Beta-2 adrenergic receptor

1

0

Small-scale

0.676

High

971993

1433E
14-3-3 protein epsilon

3

20

High-throughput

0.675

High

990724

1433Z
14-3-3 protein zeta/delta

3

20

High-throughput

0.669

High

1116779

AAMP
Angio-associated migratory cell protein

3

5

High-throughput

0.667

High

1400020

NED4L
E3 ubiquitin-protein ligase NEDD4-like

3

20

Small-scale

0.661

High

1116587

FHL3
Four and a half LIM domains protein 3

3

4

High-throughput

0.658

High

1049777

1433F
14-3-3 protein eta

3

20

High-throughput

0.650

High

1349518

METL6
tRNA N(3)-cytidine methyltransferase METTL6

3

0

High-throughput

0.638

High

691427

1433T
14-3-3 protein theta

3

20

Small-scale

0.633

High

1364795

RPGF5
Rap guanine nucleotide exchange factor 5

2

6

High-throughput

0.628

High

1413485

AASD1
Alanyl-tRNA editing protein Aarsd1

2

2

High-throughput

0.628

High

531146

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

1

18

High-throughput

0.621

High

171765

GAK
Cyclin-G-associated kinase

1

19

High-throughput

0.618

High

363854

EGFR
Epidermal growth factor receptor

1

20

Small-scale

0.618

High

831423

CCNF
Cyclin-F

1

8

High-throughput

0.618

High

1049202

RON
Macrophage-stimulating protein receptor

1

20

High-throughput

0.618

High

1108149

SQSTM
Sequestosome-1

1

6

High-throughput

0.618

High

1255527

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

1433307

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

1390678

STALP
AMSH-like protease

2

0

High-throughput

0.602

High

347323

BAG2
BAG family molecular chaperone regulator 2

2

5

High-throughput

0.601

High

1143266

PLEC
Plectin

2

11

High-throughput

0.601

High

727509

ZEP2
Transcription factor HIVEP2

1

6

High-throughput

0.590

High

1433310

TENS1
Tensin-1

1

10

High-throughput

0.590

High

1026225

CLH1
Clathrin heavy chain 1

2

5

High-throughput

0.586

High

1156212

ZYX
Zyxin

2

8

High-throughput

0.586

High

483395

CLCB
Clathrin light chain B

2

6

High-throughput

0.584

High

1433308

RMD5A
E3 ubiquitin-protein transferase RMND5A

2

6

Small-scale

0.584

High

541058

PIM1
Serine/threonine-protein kinase pim-1

1

17

High-throughput

0.575

High

173355

XPO1
Exportin-1

2

18

High-throughput

0.571

High

935131

TERA
Transitional endoplasmic reticulum ATPase

2

7

High-throughput

0.571

High

967967

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

19

Small-scale

0.561

High

1032544

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

6

High-throughput

0.541

High

1370374

CSN5
COP9 signalosome complex subunit 5

1

5

High-throughput

0.541

High

329168

RCBT2
RCC1 and BTB domain-containing protein 2

1

7

High-throughput

0.536

High

336777

BAG4
BAG family molecular chaperone regulator 4

1

3

High-throughput

0.536

High

636894

GSTM3
Glutathione S-transferase Mu 3

1

1

High-throughput

0.536

High

642586

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

1

High-throughput

0.536

High

682611

S100P
Protein S100-P

1

9

High-throughput

0.536

High

890594

RBP2
E3 SUMO-protein ligase RanBP2

1

6

High-throughput

0.536

High

946201

MLF1
Myeloid leukemia factor 1

1

5

High-throughput

0.536

High

1123115

FHL2
Four and a half LIM domains protein 2

1

4

High-throughput

0.536

High

1292237

LONP2
Lon protease homolog 2, peroxisomal

1

5

High-throughput

0.536

High

1383854

EFMT3
EEF1A lysine methyltransferase 3

1

5

High-throughput

0.536

High

1433319

GTSE1
G2 and S phase-expressed protein 1

1

1

High-throughput

0.536

High

1433321

SPB13
Serpin B13

1

1

High-throughput

0.536

High

279494

TULP3
Tubby-related protein 3

1

0

High-throughput

0.518

High

730886

1433S
14-3-3 protein sigma

1

20

High-throughput

0.515

High

1310406

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1433313

MOG1
Ran guanine nucleotide release factor

1

0

High-throughput

0.513

High

1433318

HAOX2
2-Hydroxyacid oxidase 2

1

0

High-throughput

0.513

High

927546

ATX1
Ataxin-1

1

2

High-throughput

0.508

High

993749

UBC9
SUMO-conjugating enzyme UBC9

1

10

Small-scale

0.501

High

426575

HMGN2
Non-histone chromosomal protein HMG-17

1

0

High-throughput

0.493

High

1219197

SPAT1
Spermatogenesis-associated protein 1

1

1

High-throughput

0.489

High

1326741

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

1

High-throughput

0.489

High

143473

E2F3
Transcription factor E2F3

1

3

Small-scale

0.481

High

347930

BAG3
BAG family molecular chaperone regulator 3

1

3

High-throughput

0.481

High

624672

SL9A1
Sodium/hydrogen exchanger 1

1

2

High-throughput

0.481

High

1125399

FLNC
Filamin-C

1

12

High-throughput

0.481

High

1152470

T22D1
TSC22 domain family protein 1

1

20

High-throughput

0.481

High

1336842

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

6

High-throughput

0.481

High

1402300

RANB9
Ran-binding protein 9

1

6

High-throughput

0.481

High

1432292

ZN106
Zinc finger protein 106

1

4

High-throughput

0.481

High

211599

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

4

Small-scale

0.479

High

276860

VATG1
V-type proton ATPase subunit G 1

1

1

High-throughput

0.479

High

326037

UBR5
E3 ubiquitin-protein ligase UBR5

1

20

Small-scale

0.479

High

459754

PROF1
Profilin-1

1

3

High-throughput

0.479

High

483214

CLCA
Clathrin light chain A

1

6

High-throughput

0.479

High

552697

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

5

High-throughput

0.479

High

572213

TRI27
Zinc finger protein RFP

1

6

Small-scale

0.479

High

589675

RFA2
Replication protein A 32 kDa subunit

1

6

High-throughput

0.479

High

613460

VINC
Vinculin

1

5

High-throughput

0.479

High

696494

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

824357

RL13A
Large ribosomal subunit protein uL13

1

1

High-throughput

0.479

High

989119

AP2B1
AP-2 complex subunit beta

1

13

High-throughput

0.479

High

1107611

PICAL
Phosphatidylinositol-binding clathrin assembly protein

1

5

High-throughput

0.479

High

1138632

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.479

High

1272745

MAEA
E3 ubiquitin-protein transferase MAEA

1

6

Small-scale

0.479

High

1276783

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

8

High-throughput

0.479

High

1289626

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

1367266

ESR2
Estrogen receptor beta

1

18

High-throughput

0.479

High

1368119

HDAC2
Histone deacetylase 2

1

8

High-throughput

0.479

High

1371686

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

8

Small-scale

0.479

High

1388640

SPDLY
Protein Spindly

1

14

High-throughput

0.479

High

1429840

TOLIP
Toll-interacting protein

1

1

High-throughput

0.479

High

1432898

PTN23
Tyrosine-protein phosphatase non-receptor type 23

1

10

Small-scale

0.479

High

1433330

TACC3
Transforming acidic coiled-coil-containing protein 3

1

9

High-throughput

0.479

High

286281

CSDE1
Cold shock domain-containing protein E1

1

0

High-throughput

0.460

High

1433309

RENT2
Regulator of nonsense transcripts 2

1

0

High-throughput

0.460

High

122552

ADAS
Alkyldihydroxyacetonephosphate synthase, peroxisomal

1

0

High-throughput

0.458

High

1403570

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.458

High

1433314

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.458

High

1433325

CIA2B
Cytosolic iron-sulfur assembly component 2B

1

0

High-throughput

0.458

High

217521

E41L2
Band 4.1-like protein 2

1

7

High-throughput

0.457

High

639311

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

5

High-throughput

0.457

High

702161

ITPI2
Protein ITPRID2

1

3

High-throughput

0.457

High

773021

MYH9
Myosin-9

1

3

High-throughput

0.457

High

1081717

CGNL1
Cingulin-like protein 1

1

4

High-throughput

0.457

High

1094317

LCP2
Lymphocyte cytosolic protein 2

1

5

High-throughput

0.457

High

1094736

CAF1A
Chromatin assembly factor 1 subunit A

1

5

High-throughput

0.457

High

1121879

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

7

High-throughput

0.457

High

1228172

RPGP2
Rap1 GTPase-activating protein 2

1

3

High-throughput

0.457

High

1295617

RASL3
RAS protein activator like-3

1

15

High-throughput

0.457

High

1325448

SYNPO
Synaptopodin

1

11

High-throughput

0.457

High

1360618

MADD
MAP kinase-activating death domain protein

1

1

High-throughput

0.457

High

1370805

BAD
Bcl2-associated agonist of cell death

1

2

High-throughput

0.457

High

1428969

WWTR1
WW domain-containing transcription regulator protein 1

1

20

High-throughput

0.457

High

1433311

CPAP
Centrosomal P4.1-associated protein

1

7

High-throughput

0.457

High

1433317

FA13B
Protein FAM13B

1

17

High-throughput

0.457

High

1433323

HDAC9
Histone deacetylase 9

1

12

High-throughput

0.457

High

1433324

SYNP2
Synaptopodin-2

1

7

High-throughput

0.457

High

1433329

FHOD1
FH1/FH2 domain-containing protein 1

1

2

High-throughput

0.457

High

127183

APBB1
Amyloid beta precursor protein binding family B member 1

1

1

High-throughput

0.445

High

142417

PEX7
Peroxisomal targeting signal 2 receptor

1

6

High-throughput

0.445

High

1034063

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

1

High-throughput

0.445

High

1258577

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

14

High-throughput

0.445

High

1090048

IRAG2
Inositol 1,4,5-triphosphate receptor associated 2

1

0

High-throughput

0.438

High

1336976

SIMC1
SUMO-interacting motif-containing protein 1

1

0

High-throughput

0.438

High

1366094

K0232
Uncharacterized protein KIAA0232

1

0

High-throughput

0.438

High

1403785

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.438

High

1405212

MPP9
M-phase phosphoprotein 9

1

0

High-throughput

0.438

High

1433312

MSL2
E3 ubiquitin-protein ligase MSL2

1

0

High-throughput

0.438

High

1433316

FA53C
Protein FAM53C

1

0

High-throughput

0.438

High

1433328

RIPR2
Rho family-interacting cell polarization regulator 2

1

0

High-throughput

0.438

High

769166

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

1241956

FBX42
F-box only protein 42

1

10

High-throughput

0.437

High

1433315

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

17

High-throughput

0.437

High

94332

D6R9G5
Kelch like family member 2

1

19

High-throughput

0.407

High

330317

VENTX
Homeobox protein VENTX

1

3

High-throughput

0.407

High

397812

ATP8
ATP synthase F(0) complex subunit 8

1

0

High-throughput

0.251

Low

657396

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.249

Low

69324

ZN839
Zinc finger protein 839

1

0

High-throughput

0.238

Low

1104101

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025