HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: SIM2 (Q14190)
Single-minded homolog 2 (Class E basic helix-loop-helix protein 15) (bHLHe15)
Gene: SIM2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	22939624
Identification Methods	luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 724 Hs			1 667
+	Hs
		431844 HS90A_HUMAN (1-724): 0: 1072: 85.25		SIM2_HUMAN (1-667): 0: 541: 100.00
+	Hs
		431737 HS90A_HUMAN (1-724): 0: 1072: 85.25		SIM1_HUMAN (1-663): 2.16e-160: 481: 55.31
+	Mm
		432429 HS90A_MOUSE (1-724): 0: 1068: 84.31		SIM1_MOUSE (1-663): 4.14e-158: 476: 54.73
+	Hs
		432201 HS90A_HUMAN (1-724): 0: 1072: 85.25		EPAS1_HUMAN (2-667): 1.56e-133: 415: 23.86
+	Hs
		438217 HS90B_HUMAN (1-724): 0: 1086: 100.00		HIF1A_HUMAN (2-501): 2.75e-126: 395: 32.11
+	Mm
		432431 HS90A_MOUSE (1-724): 0: 1068: 84.31		HIF1A_MOUSE (2-525): 3.97e-129: 403: 31.11
+	Hs
		431903 HS90A_HUMAN (1-724): 0: 1072: 85.25		HIF1A_HUMAN (2-501): 2.75e-126: 395: 32.11
+	Hs
		126097 HS90A_HUMAN (1-724): 0: 1072: 85.25		BMAL1_HUMAN (2-496): 1.25e-113: 356: 21.11
+	Hs
		432385 HS90A_HUMAN (1-724): 0: 1072: 85.25		HIF3A_HUMAN (2-660): 8.43e-109: 345: 26.19
+	Hs
		431556 HS90A_HUMAN (1-724): 0: 1072: 85.25		ARNT_HUMAN (2-576): 5.63e-105: 338: 16.72
+	Hs
		438468 HS90B_HUMAN (1-724): 0: 1086: 100.00		NPAS1_HUMAN (2-494): 3.68e-101: 322: 31.60
+	Mm
		513659 HS90B_MOUSE (1-724): 0: 1089: 99.59		AHR_MOUSE (5-517): 6.18e-92: 305: 22.65
+	Hs
		431594 HS90A_HUMAN (1-724): 0: 1072: 85.25		AHR_HUMAN (5-518): 5.16e-91: 303: 20.04
+	Mm
		432410 HS90A_MOUSE (1-724): 0: 1068: 84.31		AHR_MOUSE (5-517): 6.18e-92: 305: 22.65
+	Rn
		783943 HS90A_RAT (1-724): 0: 1070: 84.45		AHR_RAT (5-518): 3.38e-91: 303: 22.81
+	Hs
		432199 HS90A_HUMAN (1-724): 0: 1072: 85.25		NPAS2_HUMAN (2-651): 1.41e-86: 290: 17.06
+	Dm
		1096504 Q9VAY2_DROME (4-692): 0: 848: 46.14		SIMA_DROME (2-665): 6.85e-96: 325: 23.04
+	Hs
		1050577 Q6PK50_HUMAN (1-350): 0: 618: 99.71		SIM2_HUMAN (1-667): 0: 541: 100.00