Protein: CNOT3
CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3) (Leukocyte receptor cluster member 2)

Gene: CNOT3
Organism: Homo sapiens
Interactions: 177
UniProt ID: O75175

Gene Ontology (top 5):
GO:0000289 - nuclear-transcribed mRNA poly(A) tail shortening
GO:0000932 - P-body
GO:0001829 - trophectodermal cell differentiation
GO:0005634 - nucleus
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

273942

CNOT2
CCR4-NOT transcription complex subunit 2

11

15

Small-scale

0.977

High

63916

CNOT1
CCR4-NOT transcription complex subunit 1

6

10

Small-scale

0.943

High

273947

CNOT7
CCR4-NOT transcription complex subunit 7

5

13

High-throughput

0.712

High

273902

TNR6A
Trinucleotide repeat-containing gene 6A protein

4

20

Small-scale

0.692

High

273831

CAZA2
F-actin-capping protein subunit alpha-2

4

4

High-throughput

0.691

High

273935

TNR6C
Trinucleotide repeat-containing gene 6C protein

4

20

Small-scale

0.691

High

273945

CNOT8
CCR4-NOT transcription complex subunit 8

3

13

Small-scale

0.680

High

273877

RC3H1
Roquin-1

4

7

Small-scale

0.676

High

273837

TOB1
Protein Tob1

3

3

Small-scale

0.675

High

273843

NANO2
Nanos homolog 2

3

7

Small-scale

0.667

High

273832

CAPZB
F-actin-capping protein subunit beta

3

3

High-throughput

0.662

High

273918

CNO6L
CCR4-NOT transcription complex subunit 6-like

3

12

Small-scale

0.662

High

273949

CNO11
CCR4-NOT transcription complex subunit 11

3

2

High-throughput

0.662

High

273950

CNOT6
CCR4-NOT transcription complex subunit 6

3

12

Small-scale

0.657

High

273908

CNOT9
CCR4-NOT transcription complex subunit 9

3

9

High-throughput

0.650

High

273797

GA45B
Growth arrest and DNA damage-inducible protein GADD45 beta

2

1

High-throughput

0.628

High

273898

MINK1
Misshapen-like kinase 1

2

12

High-throughput

0.628

High

273808

MMP7
Matrilysin

3

1

High-throughput

0.609

High

273897

RIBC1
RIB43A-like with coiled-coils protein 1

3

1

High-throughput

0.604

High

273879

OBI1
ORC ubiquitin ligase 1

3

2

Small-scale

0.603

High

273847

NCS1
Neuronal calcium sensor 1

2

0

High-throughput

0.602

High

273824

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

2

5

High-throughput

0.601

High

273926

TB182
182 kDa tankyrase-1-binding protein

2

13

Small-scale

0.601

High

273932

CNO10
CCR4-NOT transcription complex subunit 10

2

2

High-throughput

0.601

High

273892

Z3H7A
Zinc finger CCCH domain-containing protein 7A

2

6

High-throughput

0.584

High

273933

RC3H2
Roquin-2

2

17

Small-scale

0.584

High

273952

TNR6B
Trinucleotide repeat-containing gene 6B protein

2

16

Small-scale

0.584

High

273921

TX13A
Testis-expressed protein 13A

2

1

High-throughput

0.574

High

273803

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

273801

CNOT4
CCR4-NOT transcription complex subunit 4

1

5

Small-scale

0.561

High

273905

NANO1
Nanos homolog 1

2

7

Small-scale

0.558

High

273919

FACOS
FANCD2 opposite strand protein

2

1

High-throughput

0.549

High

64785

EPAB2
Embryonic polyadenylate-binding protein 2

1

7

High-throughput

0.536

High

273798

SEGN
Secretagogin

1

8

High-throughput

0.536

High

273802

BAG2
BAG family molecular chaperone regulator 2

1

2

High-throughput

0.536

High

273828

HD
Huntingtin

1

3

High-throughput

0.536

High

273829

MAGA9
Melanoma-associated antigen 9

1

7

High-throughput

0.536

High

273833

SOX2
Transcription factor SOX-2

1

7

High-throughput

0.536

High

273839

CCNH
Cyclin-H

1

3

High-throughput

0.536

High

273841

CAZA1
F-actin-capping protein subunit alpha-1

1

4

High-throughput

0.536

High

273855

EP300
Histone acetyltransferase p300

1

12

High-throughput

0.536

High

273859

TOB2
Protein Tob2

1

3

High-throughput

0.536

High

273861

FHL2
Four and a half LIM domains protein 2

1

11

High-throughput

0.536

High

273862

BTG3
Protein BTG3

1

3

High-throughput

0.536

High

273863

SRC8
Src substrate cortactin

1

20

High-throughput

0.536

High

273893

RAVR1
Ribonucleoprotein PTB-binding 1

1

8

High-throughput

0.536

High

273903

UHMK1
Serine/threonine-protein kinase Kist

1

7

High-throughput

0.536

High

273934

GPBL1
Vasculin-like protein 1

1

1

High-throughput

0.536

High

273944

NLK
Serine/threonine-protein kinase NLK

1

5

High-throughput

0.536

High

273148

CAND2
Cullin-associated NEDD8-dissociated protein 2

1

2

Small-scale

0.527

High

273852

RUNX1
Runt-related transcription factor 1

1

0

High-throughput

0.518

High

273814

PECA1
Platelet endothelial cell adhesion molecule

1

6

High-throughput

0.515

High

273820

CALR
Calreticulin

1

2

High-throughput

0.515

High

273825

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.515

High

273842

TERA
Transitional endoplasmic reticulum ATPase

1

6

High-throughput

0.515

High

273904

NEK7
Serine/threonine-protein kinase Nek7

1

1

High-throughput

0.515

High

273910

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.513

High

273954

DRG1
Developmentally-regulated GTP-binding protein 1

1

0

High-throughput

0.513

High

273960

TSSC4
U5 small nuclear ribonucleoprotein TSSC4

1

0

High-throughput

0.513

High

273870

PDK4
[Pyruvate dehydrogenase

1

2

High-throughput

0.489

High

273907

TM131
Transmembrane protein 131

1

10

High-throughput

0.489

High

273853

ID3
DNA-binding protein inhibitor ID-3

1

0

Small-scale

0.486

High

50380

MEX3A
RNA-binding protein MEX3A

1

7

Small-scale

0.479

High

141228

DDX3X
ATP-dependent RNA helicase DDX3X

1

3

High-throughput

0.479

High

172325

XPO1
Exportin-1

1

5

High-throughput

0.479

High

176430

GRRE1
Granule associated Rac and RHOG effector protein 1

1

2

High-throughput

0.479

High

180630

TIF1A
Transcription intermediary factor 1-alpha

1

20

Small-scale

0.479

High

240267

PRKN
E3 ubiquitin-protein ligase parkin

1

10

High-throughput

0.479

High

256716

H2B1K
Histone H2B type 1-K

1

19

High-throughput

0.479

High

273796

ANR17
Ankyrin repeat domain-containing protein 17

1

6

High-throughput

0.479

High

273799

CE152
Centrosomal protein of 152 kDa

1

1

High-throughput

0.479

High

273809

GLI2
Zinc finger protein GLI2

1

2

High-throughput

0.479

High

273810

GLI3
Transcriptional activator GLI3

1

2

High-throughput

0.479

High

273811

HSP7C
Heat shock cognate 71 kDa protein

1

5

High-throughput

0.479

High

273812

PABP1
Polyadenylate-binding protein 1

1

4

High-throughput

0.479

High

273813

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.479

High

273817

DDX6
Probable ATP-dependent RNA helicase DDX6

1

5

High-throughput

0.479

High

273818

TTP
mRNA decay activator protein ZFP36

1

8

High-throughput

0.479

High

273819

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

273821

RBMS1
RNA-binding motif, single-stranded-interacting protein 1

1

7

High-throughput

0.479

High

273822

MARCS
Myristoylated alanine-rich C-kinase substrate

1

4

Small-scale

0.479

High

273827

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

1

High-throughput

0.479

High

273834

PRC2A
Protein PRRC2A

1

14

High-throughput

0.479

High

273838

FXR2
RNA-binding protein FXR2

1

10

High-throughput

0.479

High

273844

NANO3
Nanos homolog 3

1

7

Small-scale

0.479

High

273845

IF4A1
Eukaryotic initiation factor 4A-I

1

5

High-throughput

0.479

High

273846

RS20
Small ribosomal subunit protein uS10

1

3

High-throughput

0.479

High

273848

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

273849

H4
Histone H4

1

3

High-throughput

0.479

High

273850

H2B1C
Histone H2B type 1-C/E/F/G/I

1

19

High-throughput

0.479

High

273854

TF65
Transcription factor p65

1

4

High-throughput

0.479

High

273856

CUL3
Cullin-3

1

3

High-throughput

0.479

High

273857

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

6

High-throughput

0.479

High

273860

UBP2L
Ubiquitin-associated protein 2-like

1

14

High-throughput

0.479

High

273864

CAPR1
Caprin-1

1

5

High-throughput

0.479

High

273865

PUM1
Pumilio homolog 1

1

8

High-throughput

0.479

High

273868

STIL
SCL-interrupting locus protein

1

1

High-throughput

0.479

High

273869

CCDC6
Coiled-coil domain-containing protein 6

1

7

High-throughput

0.479

High

273872

CPEB4
Cytoplasmic polyadenylation element-binding protein 4

1

12

High-throughput

0.479

High

273875

SMAG2
Protein Smaug homolog 2

1

1

High-throughput

0.479

High

273878

MEX3C
RNA-binding E3 ubiquitin-protein ligase MEX3C

1

4

Small-scale

0.479

High

273880

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.479

High

273883

CEP85
Centrosomal protein of 85 kDa

1

8

High-throughput

0.479

High

273884

MEX3B
RNA-binding protein MEX3B

1

4

High-throughput

0.479

High

273886

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

6

High-throughput

0.479

High

273887

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

6

High-throughput

0.479

High

273888

YTHD3
YTH domain-containing family protein 3

1

13

High-throughput

0.479

High

273889

PATL1
Protein PAT1 homolog 1

1

15

High-throughput

0.479

High

273890

EST1A
Telomerase-binding protein EST1A

1

5

High-throughput

0.479

High

273891

TAXB1
Tax1-binding protein 1

1

2

High-throughput

0.479

High

273894

SRRM1
Serine/arginine repetitive matrix protein 1

1

9

High-throughput

0.479

High

273896

CNTRB
Centrobin

1

2

High-throughput

0.479

High

273899

SERB1
SERPINE1 mRNA-binding protein 1

1

4

High-throughput

0.479

High

273901

LS14A
Protein LSM14 homolog A

1

6

High-throughput

0.479

High

273906

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

5

High-throughput

0.479

High

273909

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

273911

DAZL
Deleted in azoospermia-like

1

10

High-throughput

0.479

High

273916

FUBP3
Far upstream element-binding protein 3

1

2

High-throughput

0.479

High

273917

SNX27
Sorting nexin-27

1

15

High-throughput

0.479

High

273923

YTHD1
YTH domain-containing family protein 1

1

12

High-throughput

0.479

High

273924

CPEB1
Cytoplasmic polyadenylation element-binding protein 1

1

8

High-throughput

0.479

High

273927

MKRN2
E3 ubiquitin-protein ligase makorin-2

1

1

High-throughput

0.479

High

273930

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

273931

TDRD3
Tudor domain-containing protein 3

1

2

High-throughput

0.479

High

273936

DCP1A
mRNA-decapping enzyme 1A

1

4

High-throughput

0.479

High

273937

4ET
Eukaryotic translation initiation factor 4E transporter

1

2

High-throughput

0.479

High

273940

F120C
Constitutive coactivator of PPAR-gamma-like protein 2

1

1

High-throughput

0.479

High

273946

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

273948

AGO2
Protein argonaute-2

1

6

High-throughput

0.479

High

273955

NINL
Ninein-like protein

1

5

High-throughput

0.479

High

273956

R3HD2
R3H domain-containing protein 2

1

8

High-throughput

0.479

High

273959

YTHD2
YTH domain-containing family protein 2

1

13

High-throughput

0.479

High

273866

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

273928

PAIP1
Polyadenylate-binding protein-interacting protein 1

1

0

High-throughput

0.458

High

273941

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

273938

DISC1
Disrupted in schizophrenia 1 protein

1

2

High-throughput

0.457

High

47475

RPSA2
Small ribosomal subunit protein uS2B

1

2

High-throughput

0.445

High

273800

ARI2
E3 ubiquitin-protein ligase ARIH2

1

8

High-throughput

0.445

High

273816

DGKA
Diacylglycerol kinase alpha

1

1

High-throughput

0.445

High

273830

RECQ1
ATP-dependent DNA helicase Q1

1

3

High-throughput

0.445

High

273835

PAXI
Paxillin

1

11

High-throughput

0.445

High

273836

GUAA
GMP synthase [glutamine-hydrolyzing]

1

3

High-throughput

0.445

High

273851

NFKB2
Nuclear factor NF-kappa-B p100 subunit

1

7

High-throughput

0.445

High

273858

FHL1
Four and a half LIM domains protein 1

1

10

High-throughput

0.445

High

273867

NADC
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

1

2

High-throughput

0.445

High

273874

KLH22
Kelch-like protein 22

1

1

High-throughput

0.445

High

273876

CE170
Centrosomal protein of 170 kDa

1

9

High-throughput

0.445

High

273881

TENS3
Tensin-3

1

5

High-throughput

0.445

High

273882

TRI68
E3 ubiquitin-protein ligase TRIM68

1

4

High-throughput

0.445

High

273912

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

2

High-throughput

0.445

High

273915

PDLI5
PDZ and LIM domain protein 5

1

6

High-throughput

0.445

High

273920

CDC5L
Cell division cycle 5-like protein

1

1

High-throughput

0.445

High

273943

LMCD1
LIM and cysteine-rich domains protein 1

1

11

High-throughput

0.445

High

273951

TRI33
E3 ubiquitin-protein ligase TRIM33

1

8

High-throughput

0.445

High

273953

PLAP
Phospholipase A-2-activating protein

1

4

High-throughput

0.445

High

273957

RRP44
Exosome complex exonuclease RRP44

1

1

High-throughput

0.445

High

273807

NTRK1
High affinity nerve growth factor receptor

1

7

High-throughput

0.437

High

273823

RFA3
Replication protein A 14 kDa subunit

1

7

High-throughput

0.437

High

273885

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.437

High

273900

RN214
RING finger protein 214

1

3

High-throughput

0.437

High

273914

ENTR1
Endosome-associated-trafficking regulator 1

1

2

High-throughput

0.437

High

273925

UNK
RING finger protein unkempt homolog

1

9

High-throughput

0.437

High

273929

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.437

High

273958

MARF1
Meiosis regulator and mRNA stability factor 1

1

2

High-throughput

0.437

High

249939

OGA
Protein O-GlcNAcase

1

0

High-throughput

0.426

High

273806

KITH
Thymidine kinase, cytosolic

1

0

High-throughput

0.426

High

273826

CAPG
Macrophage-capping protein

1

0

High-throughput

0.426

High

273913

OTUL
Ubiquitin thioesterase otulin

1

0

High-throughput

0.426

High

273815

ITA2
Integrin alpha-2

1

4

High-throughput

0.407

High

273895

SMAP1
Stromal membrane-associated protein 1

1

4

High-throughput

0.407

High

273840

MAT1
CDK-activating kinase assembly factor MAT1

1

0

High-throughput

0.279

Low

273873

AX2R
Annexin-2 receptor

1

0

High-throughput

0.279

Low

273939

ABCF3
ATP-binding cassette sub-family F member 3

1

0

High-throughput

0.279

Low

273805

OAT
Ornithine aminotransferase, mitochondrial

1

0

High-throughput

0.269

Low

273804

SODM
Superoxide dismutase [Mn], mitochondrial

1

0

High-throughput

0.232

Low

273871

THTR
Thiosulfate sulfurtransferase

1

0

High-throughput

0.232

Low

273922

HDHD5
Haloacid dehalogenase-like hydrolase domain-containing 5

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025