HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: STK38 (Q15208)
Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1)
Gene: STK38

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	22939624
Identification Methods	luminescence based mammalian interactome mapping, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045296 - cadherin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 465
+	Hs
		431870 HS90A_HUMAN (1-724): 0: 1072: 85.25		STK38_HUMAN (1-465): 0: 527: 100.00
+	Hs
		438637 HS90B_HUMAN (1-724): 0: 1086: 100.00		ST38L_HUMAN (11-465): 5.84e-178: 508: 87.47
+	Hs
		438558 HS90B_HUMAN (1-724): 0: 1086: 100.00		LATS2_HUMAN (5-465): 2.49e-150: 457: 40.58
+	Hs
		325599 HS90B_HUMAN (1-724): 0: 1086: 100.00		LATS1_HUMAN (7-448): 7.81e-146: 446: 40.48
+	Hs
		432293 HS90A_HUMAN (1-724): 0: 1072: 85.25		LATS2_HUMAN (5-465): 2.49e-150: 457: 40.58
+	Mm
		513660 HS90B_MOUSE (1-724): 0: 1089: 99.59		AKT1_MOUSE (50-447): 2.25e-137: 405: 27.16
+	Hs
		437927 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT1_HUMAN (36-447): 7.66e-138: 406: 27.06
+	Hs
		438633 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT3_HUMAN (37-447): 1.08e-137: 406: 27.83
+	Hs
		437928 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT2_HUMAN (6-447): 2.1e-137: 405: 24.45
+	Bt
		964601 HS90B_BOVIN (1-724): 0: 1085: 99.59		AKT1_BOVIN (36-447): 7.58e-138: 406: 27.06
+	Hs
		431572 HS90A_HUMAN (1-724): 0: 1072: 85.25		AKT1_HUMAN (36-447): 7.66e-138: 406: 27.06
+	Hs
		431573 HS90A_HUMAN (1-724): 0: 1072: 85.25		AKT2_HUMAN (6-447): 2.1e-137: 405: 24.45
+	Hs
		437870 HS90B_HUMAN (1-724): 0: 1086: 100.00		KAPCA_HUMAN (59-418): 5.12e-128: 376: 33.15
+	Hs
		437900 HS90B_HUMAN (1-724): 0: 1086: 100.00		KAPCB_HUMAN (74-418): 6.95e-128: 376: 34.29
+	Hs
		431511 HS90A_HUMAN (1-724): 0: 1072: 85.25		KAPCA_HUMAN (59-418): 5.12e-128: 376: 33.15
+	Hs
		431538 HS90A_HUMAN (1-724): 0: 1072: 85.25		KAPCB_HUMAN (74-418): 6.95e-128: 376: 34.29
+	Hs
		70435 HS90A_HUMAN (1-724): 0: 1072: 85.25		B2RB89_HUMAN (74-418): 6.95e-128: 376: 34.29
+	Hs
		438108 HS90B_HUMAN (1-724): 0: 1086: 100.00		DMPK_HUMAN (77-411): 1.19e-85: 276: 41.28
+	Hs
		438138 HS90B_HUMAN (1-724): 0: 1086: 100.00		ROCK1_HUMAN (70-415): 3.59e-79: 270: 42.90
+	Hs
		431783 HS90A_HUMAN (1-724): 0: 1072: 85.25		DMPK_HUMAN (77-411): 1.19e-85: 276: 41.28