Protein: SEPT3
Neuronal-specific septin-3

Gene: SEPT3, SEPTIN3
Organism: Homo sapiens
Interactions: 62
UniProt ID: Q9UH03

Gene Ontology (top 5):
GO:0003924 - GTPase activity
GO:0005525 - GTP binding
GO:0005940 - septin ring
GO:0008104 - intracellular protein localization
GO:0015630 - microtubule cytoskeleton

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1121204

SEPT6
Septin-6

6

19

High-throughput

0.948

High

1361616

SEPT1
Septin-1

5

19

High-throughput

0.926

High

1137024

SEPT2
Septin-2

5

19

High-throughput

0.925

High

1156431

SEPT7
Septin-7

5

20

High-throughput

0.925

High

1365296

SEPT8
Septin-8

5

19

High-throughput

0.925

High

1450363

SEP11
Septin-11

5

19

High-throughput

0.925

High

1459673

SEPT9
Septin-9

4

20

High-throughput

0.903

High

1406711

SEPT5
Septin-5

4

20

High-throughput

0.892

High

1454083

SEP10
Septin-10

4

20

High-throughput

0.892

High

1459672

SEPT3
Neuronal-specific septin-3

3

20

High-throughput

0.861

High

210508

SEPT4
Septin-4

3

20

High-throughput

0.861

High

1256431

SEP14
Septin-14

3

20

High-throughput

0.861

High

1315282

SEP12
Septin-12

3

20

High-throughput

0.861

High

1432841

BORG4
Cdc42 effector protein 4

4

14

High-throughput

0.691

High

302660

RNF8
E3 ubiquitin-protein ligase RNF8

4

5

High-throughput

0.637

High

1326821

CBR4
3-oxoacyl-[acyl-carrier-protein] reductase

4

1

High-throughput

0.630

High

1363508

DHB8
(3R)-3-hydroxyacyl-CoA dehydrogenase

4

1

High-throughput

0.630

High

140472

SDCB1
Syntenin-1

3

4

High-throughput

0.616

High

1436457

MOB1A
MOB kinase activator 1A

3

3

High-throughput

0.616

High

1400461

BTBD9
BTB/POZ domain-containing protein 9

3

1

High-throughput

0.609

High

914791

RM12
Large ribosomal subunit protein bL12m

3

9

High-throughput

0.604

High

1327615

WDTC1
WD and tetratricopeptide repeats protein 1

3

4

High-throughput

0.604

High

791804

SYUA
Alpha-synuclein

2

7

High-throughput

0.586

High

1450781

KTU
Protein kintoun

2

3

High-throughput

0.574

High

1450303

PCMD2
Protein-L-isoaspartate O-methyltransferase domain-containing protein 2

2

1

High-throughput

0.558

High

1158590

CDC37
Hsp90 co-chaperone Cdc37

2

1

High-throughput

0.553

High

1386903

DDT4L
DNA damage-inducible transcript 4-like protein

2

2

High-throughput

0.553

High

1133190

LASP1
LIM and SH3 domain protein 1

1

2

High-throughput

0.523

High

397151

ESR1
Estrogen receptor

2

12

High-throughput

0.521

High

1428404

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

4

Small-scale

0.516

High

1191999

TBB8
Tubulin beta-8 chain

1

0

High-throughput

0.513

High

952374

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

4

Small-scale

0.506

High

1361845

RSPH1
Radial spoke head 1 homolog

1

2

High-throughput

0.494

High

773680

COPB2
Coatomer subunit beta'

1

9

High-throughput

0.489

High

906943

GPM6A
Neuronal membrane glycoprotein M6-a

1

1

High-throughput

0.489

High

1390313

TRI11
E3 ubiquitin-protein ligase TRIM11

1

2

High-throughput

0.489

High

1398167

PCMD1
Protein-L-isoaspartate O-methyltransferase domain-containing protein 1

1

1

High-throughput

0.489

High

1399438

ACAP3
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3

1

10

High-throughput

0.489

High

1161249

MK06
Mitogen-activated protein kinase 6

1

1

High-throughput

0.464

High

530520

TAU
Microtubule-associated protein tau

1

14

High-throughput

0.445

High

890694

RGS3
Regulator of G-protein signaling 3

1

9

High-throughput

0.445

High

1368510

CBP
CREB-binding protein

1

4

Small-scale

0.439

High

106798

APRIO
Alternative prion protein

1

8

High-throughput

0.437

High

363978

EGFR
Epidermal growth factor receptor

1

17

High-throughput

0.437

High

541741

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.437

High

648714

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.437

High

710911

EPHB2
Ephrin type-B receptor 2

1

14

High-throughput

0.437

High

1255965

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.437

High

255265

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

3

High-throughput

0.407

High

935248

TERA
Transitional endoplasmic reticulum ATPase

1

5

High-throughput

0.407

High

956692

CKS1
Cyclin-dependent kinases regulatory subunit 1

3

0

High-throughput

0.352

High

1005217

RNF4
E3 ubiquitin-protein ligase RNF4

2

0

High-throughput

0.316

High

1139599

S39AE
Metal cation symporter ZIP14

2

0

High-throughput

0.316

High

1437658

PELI2
E3 ubiquitin-protein ligase pellino homolog 2

2

0

High-throughput

0.316

High

1392946

NTAQ1
Protein N-terminal glutamine amidohydrolase

1

0

High-throughput

0.299

High

630196

ACM3
Muscarinic acetylcholine receptor M3

1

0

High-throughput

0.282

High

1459674

NUFP1
FMR1-interacting protein NUFIP1

1

0

High-throughput

0.279

Low

252549

SEP15
Selenoprotein F

1

0

Small-scale

0.265

Low

941295

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.251

Low

1381246

WBP2
WW domain-binding protein 2

1

0

High-throughput

0.238

Low

1449154

MBIP1
MAP3K12-binding inhibitory protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025