HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: NEK8 (Q86SG6)
Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (Nima-related protein kinase 12a)
Gene: NEK8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	32707033, 22939624
Identification Methods	affinity chromatography technology, pull down, luminescence based mammalian interactome mapping
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 692
+	Hs
		432008 HS90A_HUMAN (1-724): 0: 1072: 85.25		NEK8_HUMAN (1-692): 0: 727: 100.00
+	Hs
		438382 HS90B_HUMAN (1-724): 0: 1086: 100.00		NEK9_HUMAN (3-689): 0: 603: 34.37
+	Hs
		432092 HS90A_HUMAN (1-724): 0: 1072: 85.25		NEK9_HUMAN (3-689): 0: 603: 34.37
+	Hs
		438441 HS90B_HUMAN (1-724): 0: 1086: 100.00		KCC1G_HUMAN (4-457): 1.74e-127: 388: 22.51
+	Hs
		432166 HS90A_HUMAN (1-724): 0: 1072: 85.25		KCC1G_HUMAN (4-457): 1.74e-127: 388: 22.51
+	Hs
		438147 HS90B_HUMAN (1-724): 0: 1086: 100.00		KCC2G_HUMAN (2-401): 7.59e-121: 373: 23.80
+	Hs
		437928 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT2_HUMAN (1-313): 7.99e-120: 368: 25.94
+	Hs
		437870 HS90B_HUMAN (1-724): 0: 1086: 100.00		KAPCA_HUMAN (1-308): 1.8e-119: 362: 25.48
+	Hs
		437900 HS90B_HUMAN (1-724): 0: 1086: 100.00		KAPCB_HUMAN (1-308): 3.33e-119: 361: 26.43
+	Hs
		431826 HS90A_HUMAN (1-724): 0: 1072: 85.25		KCC2G_HUMAN (2-401): 7.59e-121: 373: 23.80
+	Hs
		431573 HS90A_HUMAN (1-724): 0: 1072: 85.25		AKT2_HUMAN (1-313): 7.99e-120: 368: 25.94
+	Hs
		431511 HS90A_HUMAN (1-724): 0: 1072: 85.25		KAPCA_HUMAN (1-308): 1.8e-119: 362: 25.48
+	Hs
		431538 HS90A_HUMAN (1-724): 0: 1072: 85.25		KAPCB_HUMAN (1-308): 3.33e-119: 361: 26.43
+	Hs
		70435 HS90A_HUMAN (1-724): 0: 1072: 85.25		B2RB89_HUMAN (1-308): 3.33e-119: 361: 26.43
+	Hs
		438015 HS90B_HUMAN (1-724): 0: 1086: 100.00		NEK4_HUMAN (1-313): 5.52e-60: 218: 37.14
+	Hs
		431675 HS90A_HUMAN (1-724): 0: 1072: 85.25		NEK4_HUMAN (1-313): 5.52e-60: 218: 37.14
+	Hs
		438014 HS90B_HUMAN (1-724): 0: 1086: 100.00		NEK2_HUMAN (2-257): 1.17e-53: 192: 40.23
+	Hs
		438369 HS90B_HUMAN (1-724): 0: 1086: 100.00		NEK11_HUMAN (3-265): 6.17e-47: 178: 36.06
+	Hs
		432077 HS90A_HUMAN (1-724): 0: 1072: 85.25		NEK11_HUMAN (3-265): 6.17e-47: 178: 36.06
+	Hs
		432294 HS90A_HUMAN (1-724): 0: 1072: 85.25		STK36_HUMAN (1-257): 4.66e-36: 148: 33.85