HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: PDK1L (Q8N165)
Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1-interacting kinase 1-like)
Gene: PDIK1L

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.903

Property	Details
Experiments	28514442, 33961781, 32707033, 22939624
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down, luminescence based mammalian interactome mapping
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 341
+	Hs
		438385 HS90B_HUMAN (1-724): 0: 1086: 100.00		STK35_HUMAN (3-332): 1.4e-127: 377: 68.73
+	Hs
		432094 HS90A_HUMAN (1-724): 0: 1072: 85.25		STK35_HUMAN (3-332): 1.4e-127: 377: 68.73
+	Hs
		437908 HS90B_HUMAN (1-724): 0: 1086: 100.00		CDK2_HUMAN (5-337): 6.66e-114: 334: 21.78
+	Hs
		438381 HS90B_HUMAN (1-724): 0: 1086: 100.00		MK15_HUMAN (2-340): 1.49e-110: 334: 21.91
+	Hs
		438075 HS90B_HUMAN (1-724): 0: 1086: 100.00		CDK3_HUMAN (5-332): 1.5e-112: 330: 21.22
+	Hs
		431549 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK2_HUMAN (5-337): 6.66e-114: 334: 21.78
+	Hs
		432091 HS90A_HUMAN (1-724): 0: 1072: 85.25		MK15_HUMAN (2-340): 1.49e-110: 334: 21.91
+	Hs
		431741 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK3_HUMAN (5-332): 1.5e-112: 330: 21.22
+	Hs
		432048 HS90A_HUMAN (1-724): 0: 1072: 85.25		PDK1L_HUMAN (1-341): 1.05e-110: 327: 100.00
+	Hs
		414683 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK1_HUMAN (5-338): 1.3e-108: 320: 21.37
+	Hs
		438496 HS90B_HUMAN (1-724): 0: 1086: 100.00		STK33_HUMAN (8-325): 6.19e-27: 112: 28.17
+	Hs
		432234 HS90A_HUMAN (1-724): 0: 1072: 85.25		STK33_HUMAN (8-325): 6.19e-27: 112: 28.17
+	Hs
		438277 HS90B_HUMAN (1-724): 0: 1086: 100.00		ULK3_HUMAN (6-251): 1.66e-19: 90.9: 29.30
+	Hs
		438015 HS90B_HUMAN (1-724): 0: 1086: 100.00		NEK4_HUMAN (8-320): 9.2e-19: 89.4: 24.92
+	Hs
		262221 HS90B_HUMAN (1-724): 0: 1086: 100.00		ULK1_HUMAN (112-278): 1.48e-18: 89: 33.14
+	Hs
		438350 HS90B_HUMAN (1-724): 0: 1086: 100.00		DCLK2_HUMAN (7-251): 3.08e-18: 87.8: 30.00
+	Hs
		431967 HS90A_HUMAN (1-724): 0: 1072: 85.25		ULK3_HUMAN (6-251): 1.66e-19: 90.9: 29.30
+	Hs
		431675 HS90A_HUMAN (1-724): 0: 1072: 85.25		NEK4_HUMAN (8-320): 9.2e-19: 89.4: 24.92
+	Hs
		262219 HS90A_HUMAN (1-724): 0: 1072: 85.25		ULK1_HUMAN (112-278): 1.48e-18: 89: 33.14
+	Hs
		432057 HS90A_HUMAN (1-724): 0: 1072: 85.25		DCLK2_HUMAN (7-251): 3.08e-18: 87.8: 30.00