HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: MK15 (Q8TD08)
Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8)
Gene: MAPK15

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	32707033, 22939624
Identification Methods	affinity chromatography technology, pull down, luminescence based mammalian interactome mapping
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005576 - extracellular region GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0051973 - positive regulation of telomerase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 544
+	Hs
		432091 HS90A_HUMAN (1-724): 0: 1072: 85.25		MK15_HUMAN (1-544): 0: 545: 100.00
+	Hs
		437908 HS90B_HUMAN (1-724): 0: 1086: 100.00		CDK2_HUMAN (10-315): 6.34e-141: 410: 38.31
+	Hs
		438208 HS90B_HUMAN (1-724): 0: 1086: 100.00		MK14_HUMAN (8-355): 1.49e-135: 399: 38.92
+	Hs
		438075 HS90B_HUMAN (1-724): 0: 1086: 100.00		CDK3_HUMAN (10-316): 8.82e-136: 397: 38.19
+	Hs
		431549 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK2_HUMAN (10-315): 6.34e-141: 410: 38.31
+	Hs
		431896 HS90A_HUMAN (1-724): 0: 1072: 85.25		MK14_HUMAN (8-355): 1.49e-135: 399: 38.92
+	Hs
		431741 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK3_HUMAN (10-316): 8.82e-136: 397: 38.19
+	Mm
		432419 HS90A_MOUSE (1-724): 0: 1068: 84.31		MK01_MOUSE (1-352): 3.16e-136: 400: 39.44
+	Hs
		538326 ENPL_HUMAN (3-693): 0: 917: 46.44		MK15_HUMAN (1-544): 0: 545: 100.00
+	Rn
		600340 HS90B_RAT (1-724): 0: 1089: 99.59		MK03_RAT (12-313): 1.32e-77: 251: 45.25
+	Hs
		437913 HS90B_HUMAN (1-724): 0: 1086: 100.00		MK03_HUMAN (12-313): 8.66e-78: 251: 45.25
+	Sc
		365698 HSP82_YEAST (12-724): 0: 927: 61.26		KSS1_YEAST (1-346): 4.36e-138: 405: 41.14
+	Hs
		538107 ENPL_HUMAN (3-693): 0: 917: 46.44		CDK2_HUMAN (10-315): 6.34e-141: 410: 38.31
+	Hs
		431555 HS90A_HUMAN (1-724): 0: 1072: 85.25		MK03_HUMAN (12-313): 8.66e-78: 251: 45.25
+	Rn
		600383 HS90A_RAT (1-724): 0: 1070: 84.45		MK03_RAT (12-313): 1.32e-77: 251: 45.25
+	Mm
		432433 HS90A_MOUSE (1-724): 0: 1068: 84.31		MK03_MOUSE (12-313): 1.32e-77: 251: 45.25
+	At
		850798 HS903_ARATH (10-724): 0: 1002: 66.57		MPK10_ARATH (17-313): 7.11e-80: 257: 45.33
+	Sc
		543134 HSC82_YEAST (13-724): 0: 922: 60.22		FUS3_YEAST (13-313): 8.9e-81: 258: 45.81
+	Sc
		366740 HSP82_YEAST (12-724): 0: 927: 61.26		SLT2_YEAST (6-313): 5.04e-75: 247: 42.36
+	Rn
		600453 ENPL_RAT (3-695): 0: 921: 45.74		MK03_RAT (12-313): 1.32e-77: 251: 45.25