Protein: IF2A
Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha) (eIF2-alpha)

Gene: IF2A, EIF2S1
Organism: Homo sapiens
Interactions: 237
UniProt ID: P05198

Gene Ontology (top 5):
GO:0000423 - mitophagy
GO:0003723 - RNA binding
GO:0003743 - translation initiation factor activity
GO:0005634 - nucleus
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

426224

IF2G
Eukaryotic translation initiation factor 2 subunit 3

14

9

Small-scale

0.979

High

426199

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

10

7

Small-scale

0.978

High

294647

PR15A
Protein phosphatase 1 regulatory subunit 15A

4

1

Small-scale

0.881

High

426194

KPCA
Protein kinase C alpha type

2

1

Small-scale

0.768

High

426217

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

2

1

High-throughput

0.737

High

426200

IF2B
Eukaryotic translation initiation factor 2 subunit 2

6

6

Small-scale

0.733

High

426248

CSK21
Casein kinase II subunit alpha

1

5

High-throughput

0.710

High

227154

DYRK3
Dual specificity tyrosine-phosphorylation-regulated kinase 3

1

2

High-throughput

0.691

High

426192

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

1

3

High-throughput

0.691

High

426202

MAK
Serine/threonine-protein kinase MAK

1

4

High-throughput

0.691

High

426303

NEK7
Serine/threonine-protein kinase Nek7

1

2

High-throughput

0.691

High

426342

ANM7
Protein arginine N-methyltransferase 7

4

0

Small-scale

0.673

High

426269

EI2BA
Translation initiation factor eIF2B subunit alpha

1

4

Small-scale

0.647

High

426324

E2AK1
Eukaryotic translation initiation factor 2-alpha kinase 1

1

12

Small-scale

0.647

High

426345

E2AK3
Eukaryotic translation initiation factor 2-alpha kinase 3

1

15

Small-scale

0.647

High

426185

TAU
Microtubule-associated protein tau

3

1

High-throughput

0.624

High

245188

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

3

High-throughput

0.618

High

156838

CTRO
Citron Rho-interacting kinase

1

3

High-throughput

0.618

High

426219

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

4

High-throughput

0.618

High

426233

PLK1
Serine/threonine-protein kinase PLK1

1

1

High-throughput

0.618

High

426274

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.618

High

426327

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

2

High-throughput

0.618

High

426257

VAC14
Protein VAC14 homolog

2

2

High-throughput

0.606

High

135014

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

0

High-throughput

0.586

High

426223

CCNF
Cyclin-F

2

0

High-throughput

0.585

High

141278

DDX3X
ATP-dependent RNA helicase DDX3X

2

3

Small-scale

0.585

High

240484

PRKN
E3 ubiquitin-protein ligase parkin

2

4

High-throughput

0.584

High

259296

BRD4
Bromodomain-containing protein 4

2

2

High-throughput

0.584

High

426193

RFA2
Replication protein A 32 kDa subunit

2

1

High-throughput

0.584

High

426205

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

1

High-throughput

0.584

High

426188

ACTN1
Alpha-actinin-1

2

0

High-throughput

0.580

High

354497

PAK4
Serine/threonine-protein kinase PAK 4

1

1

High-throughput

0.575

High

400108

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.575

High

426240

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

4

Small-scale

0.575

High

426280

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.575

High

395317

ESR1
Estrogen receptor

2

4

High-throughput

0.571

High

426198

VCAM1
Vascular cell adhesion protein 1

2

1

High-throughput

0.571

High

426236

TERA
Transitional endoplasmic reticulum ATPase

2

2

High-throughput

0.571

High

370916

MYC
Myc proto-oncogene protein

2

0

High-throughput

0.559

High

426328

ACE2
Angiotensin-converting enzyme 2

2

0

High-throughput

0.559

High

426210

1433S
14-3-3 protein sigma

1

0

Small-scale

0.537

High

295072

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

2

High-throughput

0.536

High

361053

SODC
Superoxide dismutase [Cu-Zn]

1

2

High-throughput

0.536

High

426218

RL4
Large ribosomal subunit protein uL4

1

1

High-throughput

0.536

High

426235

IF5
Eukaryotic translation initiation factor 5

1

6

High-throughput

0.536

High

426237

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

4

High-throughput

0.536

High

426238

IF4A1
Eukaryotic initiation factor 4A-I

1

2

High-throughput

0.536

High

426241

RS16
Small ribosomal subunit protein uS9

1

1

High-throughput

0.536

High

426246

RACK1
Small ribosomal subunit protein RACK1

1

6

High-throughput

0.536

High

426250

RL19
Large ribosomal subunit protein eL19

1

1

High-throughput

0.536

High

426297

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

1

High-throughput

0.536

High

426300

DDX60
Probable ATP-dependent RNA helicase DDX60

1

5

High-throughput

0.536

High

426306

PSPC1
Paraspeckle component 1

1

1

High-throughput

0.536

High

426311

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.536

High

426326

RBM42
RNA-binding protein 42

1

3

High-throughput

0.536

High

426356

G3BP2
Ras GTPase-activating protein-binding protein 2

1

2

High-throughput

0.536

High

426357

DRG1
Developmentally-regulated GTP-binding protein 1

1

1

High-throughput

0.536

High

426215

RFA3
Replication protein A 14 kDa subunit

2

1

High-throughput

0.533

High

426353

HECD1
E3 ubiquitin-protein ligase HECTD1

2

2

Small-scale

0.533

High

415270

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.518

High

254504

EIF1B
Eukaryotic translation initiation factor 1b

1

1

High-throughput

0.515

High

135451

DNM1L
Dynamin-1-like protein

1

0

High-throughput

0.513

High

303378

SRP72
Signal recognition particle subunit SRP72

1

0

High-throughput

0.513

High

407024

HG2A
HLA class II histocompatibility antigen gamma chain

1

0

High-throughput

0.513

High

426179

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.513

High

426182

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

426190

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.513

High

426204

HMGB2
High mobility group protein B2

1

0

High-throughput

0.513

High

426209

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.513

High

426226

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

426228

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

426230

MAP2
Methionine aminopeptidase 2

1

0

High-throughput

0.513

High

426232

HDGF
Hepatoma-derived growth factor

1

0

High-throughput

0.513

High

426350

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.513

High

426360

MB212
Protein mab-21-like 2

1

0

High-throughput

0.513

High

426177

HS90A
Heat shock protein HSP 90-alpha

1

3

Small-scale

0.501

High

426351

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.493

High

426254

TIE2
Angiopoietin-1 receptor

1

6

High-throughput

0.489

High

426277

CDC37
Hsp90 co-chaperone Cdc37

1

0

Small-scale

0.480

High

128712

MEN1
Menin

1

1

High-throughput

0.479

High

131661

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

1

High-throughput

0.479

High

172401

XPO1
Exportin-1

1

4

High-throughput

0.479

High

179116

ARC1B
Actin-related protein 2/3 complex subunit 1B

1

5

Small-scale

0.479

High

247207

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

1

High-throughput

0.479

High

302317

RNF8
E3 ubiquitin-protein ligase RNF8

1

2

High-throughput

0.479

High

315010

RECQ4
ATP-dependent DNA helicase Q4

1

5

High-throughput

0.479

High

345254

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

388886

FINC
Fibronectin

1

1

High-throughput

0.479

High

410515

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

2

High-throughput

0.479

High

411177

NTRK1
High affinity nerve growth factor receptor

1

7

High-throughput

0.479

High

426178

IGF1R
Insulin-like growth factor 1 receptor

1

9

High-throughput

0.479

High

426180

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

5

High-throughput

0.479

High

426181

ROS1
Proto-oncogene tyrosine-protein kinase ROS

1

7

High-throughput

0.479

High

426184

ANDR
Androgen receptor

1

4

High-throughput

0.479

High

426186

ERG
Transcriptional regulator ERG

1

1

Small-scale

0.479

High

426187

FGFR1
Fibroblast growth factor receptor 1

1

8

High-throughput

0.479

High

426189

IFM1
Interferon-induced transmembrane protein 1

1

1

High-throughput

0.479

High

426195

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.479

High

426197

VGFR1
Vascular endothelial growth factor receptor 1

1

4

High-throughput

0.479

High

426206

EPHB2
Ephrin type-B receptor 2

1

2

High-throughput

0.479

High

426207

LTK
Leukocyte tyrosine kinase receptor

1

9

High-throughput

0.479

High

426208

UFO
Tyrosine-protein kinase receptor UFO

1

7

High-throughput

0.479

High

426211

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

426216

VGFR3
Vascular endothelial growth factor receptor 3

1

5

High-throughput

0.479

High

426221

SYUA
Alpha-synuclein

1

1

High-throughput

0.479

High

426222

BRCA1
Breast cancer type 1 susceptibility protein

1

2

High-throughput

0.479

High

426225

MAP1B
Microtubule-associated protein 1B

1

3

High-throughput

0.479

High

426231

MECP2
Methyl-CpG-binding protein 2

1

2

High-throughput

0.479

High

426234

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

4

High-throughput

0.479

High

426239

WDR5
WD repeat-containing protein 5

1

5

High-throughput

0.479

High

426245

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

2

High-throughput

0.479

High

426249

IF4G2
Eukaryotic translation initiation factor 4 gamma 2

1

3

Small-scale

0.479

High

426256

DHX9
ATP-dependent RNA helicase A

1

6

Small-scale

0.479

High

426261

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

7

High-throughput

0.479

High

426262

NFX1
Transcriptional repressor NF-X1

1

1

High-throughput

0.479

High

426264

TIF1B
Transcription intermediary factor 1-beta

1

2

High-throughput

0.479

High

426265

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

426267

CUL3
Cullin-3

1

1

High-throughput

0.479

High

426268

TRI14
Tripartite motif-containing protein 14

1

1

High-throughput

0.479

High

426270

RBM39
RNA-binding protein 39

1

2

High-throughput

0.479

High

426271

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

7

High-throughput

0.479

High

426272

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

4

High-throughput

0.479

High

426273

TNIP1
TNFAIP3-interacting protein 1

1

5

High-throughput

0.479

High

426276

EZH2
Histone-lysine N-methyltransferase EZH2

1

3

High-throughput

0.479

High

426285

CDC73
Parafibromin

1

1

High-throughput

0.479

High

426286

PRP8
Pre-mRNA-processing-splicing factor 8

1

1

High-throughput

0.479

High

426288

LMTK1
Serine/threonine-protein kinase LMTK1

1

9

High-throughput

0.479

High

426289

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

1

High-throughput

0.479

High

426293

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

3

High-throughput

0.479

High

426294

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

1

Small-scale

0.479

High

426296

ZCH18
Zinc finger CCCH domain-containing protein 18

1

5

High-throughput

0.479

High

426299

LMTK2
Serine/threonine-protein kinase LMTK2

1

9

High-throughput

0.479

High

426304

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.479

High

426309

ESR2
Estrogen receptor beta

1

4

High-throughput

0.479

High

426310

RENT1
Regulator of nonsense transcripts 1

1

1

Small-scale

0.479

High

426312

FBXW7
F-box/WD repeat-containing protein 7

1

1

High-throughput

0.479

High

426316

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.479

High

426317

THOC3
THO complex subunit 3

1

4

Small-scale

0.479

High

426322

RING2
E3 ubiquitin-protein ligase RING2

1

3

High-throughput

0.479

High

426323

DNJC2
DnaJ homolog subfamily C member 2

1

1

High-throughput

0.479

High

426330

TRI31
E3 ubiquitin-protein ligase TRIM31

1

3

High-throughput

0.479

High

426333

DDX24
ATP-dependent RNA helicase DDX24

1

12

High-throughput

0.479

High

426339

BRD7
Bromodomain-containing protein 7

1

1

High-throughput

0.479

High

426341

ANLN
Anillin

1

1

High-throughput

0.479

High

426346

PD1L1
Programmed cell death 1 ligand 1

1

1

High-throughput

0.479

High

426347

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

4

High-throughput

0.479

High

426349

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

426352

ANC2
Anaphase-promoting complex subunit 2

1

2

High-throughput

0.479

High

426354

FZR1
Fizzy-related protein homolog

1

4

High-throughput

0.479

High

426355

ALK
ALK tyrosine kinase receptor

1

9

High-throughput

0.479

High

426359

TRAF6
TNF receptor-associated factor 6

1

2

High-throughput

0.479

High

426361

MAFB
Transcription factor MafB

1

2

High-throughput

0.479

High

426362

RBM8A
RNA-binding protein 8A

1

3

High-throughput

0.479

High

162889

TERT
Telomerase reverse transcriptase

1

0

Small-scale

0.460

High

125145

LEG9
Galectin-9

1

0

High-throughput

0.458

High

164219

NRP1
Neuropilin-1

1

0

High-throughput

0.458

High

177425

ZN536
Zinc finger protein 536

1

0

High-throughput

0.458

High

179798

BET1
BET1 homolog

1

0

High-throughput

0.458

High

238350

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.458

High

247597

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

319292

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

324404

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

332071

MRP6
ATP-binding cassette sub-family C member 6

1

0

Small-scale

0.458

High

426176

NPM
Nucleophosmin

1

0

High-throughput

0.458

High

426183

FURIN
Furin

1

0

High-throughput

0.458

High

426191

ITA4
Integrin alpha-4

1

0

High-throughput

0.458

High

426196

PTN2
Tyrosine-protein phosphatase non-receptor type 2

1

0

High-throughput

0.458

High

426201

BTF3
Transcription factor BTF3

1

0

High-throughput

0.458

High

426212

CTNB1
Catenin beta-1

1

0

High-throughput

0.458

High

426214

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

426242

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

426243

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.458

High

426244

RS25
Small ribosomal subunit protein eS25

1

0

High-throughput

0.458

High

426247

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.458

High

426252

EWS
RNA-binding protein EWS

1

0

High-throughput

0.458

High

426258

FOXO1
Forkhead box protein O1

1

0

High-throughput

0.458

High

426263

REST
RE1-silencing transcription factor

1

0

High-throughput

0.458

High

426278

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.458

High

426279

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.458

High

426282

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.458

High

426291

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.458

High

426292

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

426295

LYRIC
Protein LYRIC

1

0

Small-scale

0.458

High

426301

CMTR1
Cap-specific mRNA

1

0

High-throughput

0.458

High

426302

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

426307

ASB11
Ankyrin repeat and SOCS box protein 11

1

0

High-throughput

0.458

High

426308

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

426313

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.458

High

426314

SPDLY
Protein Spindly

1

0

High-throughput

0.458

High

426315

TRI11
E3 ubiquitin-protein ligase TRIM11

1

0

Small-scale

0.458

High

426318

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

426321

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.458

High

426325

RIOK1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

426329

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

0

High-throughput

0.458

High

426331

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

426335

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

426338

NMRL1
NmrA-like family domain-containing protein 1

1

0

High-throughput

0.458

High

426340

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

426343

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

426344

LYAR
Cell growth-regulating nucleolar protein

1

0

High-throughput

0.458

High

426348

HDAC6
Protein deacetylase HDAC6

1

0

High-throughput

0.458

High

426175

JUN
Transcription factor Jun

1

3

High-throughput

0.445

High

426213

BMI1
Polycomb complex protein BMI-1

1

3

High-throughput

0.445

High

426266

SNW1
SNW domain-containing protein 1

1

1

High-throughput

0.445

High

426284

PKHA7
Pleckstrin homology domain-containing family A member 7

1

2

High-throughput

0.445

High

293051

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

318573

RHBT1
Rho-related BTB domain-containing protein 1

1

2

High-throughput

0.437

High

426203

FGFR3
Fibroblast growth factor receptor 3

1

8

High-throughput

0.437

High

426220

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

4

High-throughput

0.437

High

426251

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.437

High

426253

ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

1

10

High-throughput

0.437

High

426255

RON
Macrophage-stimulating protein receptor

1

6

High-throughput

0.437

High

426260

MERTK
Tyrosine-protein kinase Mer

1

7

High-throughput

0.437

High

426281

OTUD1
OTU domain-containing protein 1

1

2

High-throughput

0.437

High

426290

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

426320

LMTK3
Serine/threonine-protein kinase LMTK3

1

11

High-throughput

0.437

High

426336

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

62441

S35F4
Solute carrier family 35 member F4

1

0

High-throughput

0.426

High

133418

ACATN
Acetyl-coenzyme A transporter 1

1

0

High-throughput

0.426

High

230154

S28A2
Sodium/nucleoside cotransporter 2

1

0

High-throughput

0.426

High

426259

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

High-throughput

0.426

High

426275

UT2
Urea transporter 2

1

0

High-throughput

0.426

High

426298

S2611
Sodium-independent sulfate anion transporter

1

0

High-throughput

0.426

High

426334

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

0

High-throughput

0.426

High

426229

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.408

High

74744

B2Y833
TMPRSS2-ERG prostate cancer specific isoform 1

1

1

Small-scale

0.407

High

402818

ANXA1
Annexin A1

1

0

Small-scale

0.391

High

426319

RILP
Rab-interacting lysosomal protein

1

0

High-throughput

0.279

Low

105118

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

239662

PCDH7
Protocadherin-7

1

0

High-throughput

0.249

Low

426227

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

426283

RNF43
E3 ubiquitin-protein ligase RNF43

1

0

High-throughput

0.249

Low

426287

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

426305

CEMIP
Cell migration-inducing and hyaluronan-binding protein

1

0

Small-scale

0.249

Low

426358

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

426332

S6A16
Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5

1

0

High-throughput

0.232

Low

426337

VIAAT
Vesicular inhibitory amino acid transporter

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025