HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: NEK9 (Q8TD19)
Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8)
Gene: NEK9

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	22939624
Identification Methods	luminescence based mammalian interactome mapping, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005829 - cytosol GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 979
+	Hs
		432092 HS90A_HUMAN (1-724): 0: 1072: 85.25		NEK9_HUMAN (1-979): 0: 1056: 100.00
+	Mm
		513660 HS90B_MOUSE (1-724): 0: 1089: 99.59		AKT1_MOUSE (13-377): 4.99e-129: 400: 20.70
+	Hs
		437928 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT2_HUMAN (6-380): 2.11e-129: 401: 21.52
+	Bt
		964601 HS90B_BOVIN (1-724): 0: 1085: 99.59		AKT1_BOVIN (13-378): 9.03e-130: 402: 20.91
+	Hs
		437927 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT1_HUMAN (13-377): 4.73e-129: 400: 20.70
+	Hs
		438633 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT3_HUMAN (8-380): 4.3e-129: 400: 19.69
+	Hs
		438441 HS90B_HUMAN (1-724): 0: 1086: 100.00		KCC1G_HUMAN (39-494): 2.3e-127: 395: 19.58
+	Hs
		431573 HS90A_HUMAN (1-724): 0: 1072: 85.25		AKT2_HUMAN (6-380): 2.11e-129: 401: 21.52
+	Hs
		431572 HS90A_HUMAN (1-724): 0: 1072: 85.25		AKT1_HUMAN (13-377): 4.73e-129: 400: 20.70
+	Hs
		432376 HS90A_HUMAN (1-724): 0: 1072: 85.25		AKT3_HUMAN (8-380): 4.3e-129: 400: 19.69
+	Rn
		812703 HS90A_RAT (1-724): 0: 1070: 84.45		AKT1_RAT (13-377): 6.58e-129: 400: 20.70
+	Hs
		432166 HS90A_HUMAN (1-724): 0: 1072: 85.25		KCC1G_HUMAN (39-494): 2.3e-127: 395: 19.58
+	Hs
		431792 HS90A_HUMAN (1-724): 0: 1072: 85.25		STK4_HUMAN (29-485): 3.87e-126: 393: 22.17
+	Hs
		438015 HS90B_HUMAN (1-724): 0: 1086: 100.00		NEK4_HUMAN (52-361): 1.15e-56: 213: 36.78
+	Hs
		431675 HS90A_HUMAN (1-724): 0: 1072: 85.25		NEK4_HUMAN (52-361): 1.15e-56: 213: 36.78
+	Hs
		438014 HS90B_HUMAN (1-724): 0: 1086: 100.00		NEK2_HUMAN (45-334): 6.31e-52: 191: 36.84
+	Hs
		438369 HS90B_HUMAN (1-724): 0: 1086: 100.00		NEK11_HUMAN (52-315): 1.9e-40: 161: 34.20
+	Hs
		432077 HS90A_HUMAN (1-724): 0: 1072: 85.25		NEK11_HUMAN (52-315): 1.9e-40: 161: 34.20
+	Hs
		438311 HS90B_HUMAN (1-724): 0: 1086: 100.00		NEK8_HUMAN (618-802): 9.67e-25: 112: 16.84
+	Hs
		432008 HS90A_HUMAN (1-724): 0: 1072: 85.25		NEK8_HUMAN (618-802): 9.67e-25: 112: 16.84