Protein: IF5A1
Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (Hypusine-containing protein HP2) (eIF-4D)

Gene: IF5A1, HYP2
Organism: Saccharomyces cerevisiae S288C
Interactions: 142
UniProt ID: P23301

Gene Ontology (top 5):
GO:0002182 - cytoplasmic translational elongation
GO:0002184 - cytoplasmic translational termination
GO:0003723 - RNA binding
GO:0003743 - translation initiation factor activity
GO:0003746 - translation elongation factor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

657087

DHYS
Deoxyhypusine synthase

3

7

Small-scale

0.871

High

657048

IF5A1
Eukaryotic translation initiation factor 5A-1

2

3

Small-scale

0.799

High

619147

IF5A2
Eukaryotic translation initiation factor 5A-2

2

3

High-throughput

0.776

High

392261

HSP82
ATP-dependent molecular chaperone HSP82

3

3

High-throughput

0.640

High

657104

DOHH
Deoxyhypusine hydroxylase

2

2

Small-scale

0.633

High

657116

BRE5
UBP3-associated protein BRE5

2

1

High-throughput

0.621

High

427140

RLA0
Large ribosomal subunit protein uL10

2

1

Small-scale

0.611

High

438620

SC160
Protein SCP160

2

2

High-throughput

0.584

High

657065

ZUO1
Zuotin

2

1

Small-scale

0.584

High

657102

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

3

High-throughput

0.584

High

509406

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

2

4

High-throughput

0.571

High

543865

SSB1
Ribosome-associated molecular chaperone SSB1

2

2

High-throughput

0.571

High

657093

SSB2
Ribosome-associated molecular chaperone SSB2

2

2

Small-scale

0.571

High

478584

IF2B
Eukaryotic translation initiation factor 2 subunit beta

2

0

Small-scale

0.559

High

502861

RS22A
Small ribosomal subunit protein uS8A

2

0

Small-scale

0.559

High

657051

SIS1
Protein SIS1

2

0

High-throughput

0.559

High

449072

CALM
Calmodulin

1

1

High-throughput

0.536

High

656364

KC11
Casein kinase I homolog 1

1

1

High-throughput

0.536

High

657073

PRS6B
26S proteasome regulatory subunit 6B homolog

1

2

High-throughput

0.536

High

657100

BUD27
Bud site selection protein 27

1

0

Small-scale

0.518

High

464555

PBS2
MAP kinase kinase PBS2

1

1

High-throughput

0.515

High

657049

EFGM
Elongation factor G, mitochondrial

1

3

High-throughput

0.515

High

657109

LYS4
Homoaconitase, mitochondrial

1

1

High-throughput

0.515

High

657111

VPS4
Vacuolar protein sorting-associated protein 4

1

2

High-throughput

0.515

High

366640

ARGI
Arginase

1

0

High-throughput

0.513

High

553904

WHI2
Growth regulation protein

1

0

High-throughput

0.513

High

633232

CKS1
Cyclin-dependent kinases regulatory subunit

1

0

High-throughput

0.513

High

657058

HRR25
Casein kinase I homolog HRR25

1

0

High-throughput

0.513

High

657119

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

0

High-throughput

0.513

High

657129

BUD20
Bud site selection protein 20

1

0

High-throughput

0.513

High

657130

RBX1
RING-box protein HRT1

1

0

High-throughput

0.513

High

657067

KA122
Importin beta-like protein KAP122

1

0

Small-scale

0.504

High

555230

RAD50
DNA repair protein RAD50

1

0

High-throughput

0.493

High

657063

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

0

High-throughput

0.493

High

657077

ANR2
Uncharacterized protein ANR2

1

0

High-throughput

0.493

High

657098

MKT1
Post-transcriptional regulator MKT1

1

0

High-throughput

0.493

High

657099

GPD2
Glycerol-3-phosphate dehydrogenase [NAD(+)] 2, mitochondrial

1

0

High-throughput

0.493

High

657101

IES1
Ino eighty subunit 1

1

0

High-throughput

0.493

High

657106

GYP3
GTPase-activating protein GYP3

1

0

High-throughput

0.493

High

657141

POC4
Proteasome chaperone 4

1

0

High-throughput

0.493

High

597599

CDC23
Anaphase-promoting complex subunit CDC23

1

1

High-throughput

0.489

High

517903

SSBP1
Single-stranded nucleic acid-binding protein

1

0

High-throughput

0.480

High

394254

EF1A
Elongation factor 1-alpha

1

1

Small-scale

0.479

High

416083

SYTC
Threonine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.479

High

416197

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

6

High-throughput

0.479

High

436323

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

4

High-throughput

0.479

High

438382

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

2

Small-scale

0.479

High

441717

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.479

High

454887

RS19A
Small ribosomal subunit protein eS19A

1

2

High-throughput

0.479

High

455373

RS19B
Small ribosomal subunit protein eS19B

1

2

Small-scale

0.479

High

509872

RL40A
Ubiquitin-ribosomal protein eL40A fusion protein [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40A

1

4

High-throughput

0.479

High

512012

RS4A
Small ribosomal subunit protein eS4A

1

1

Small-scale

0.479

High

512269

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.479

High

531607

RL4A
Large ribosomal subunit protein uL4A

1

2

Small-scale

0.479

High

569908

RL3
Large ribosomal subunit protein uL3

1

1

Small-scale

0.479

High

578879

HSC82
ATP-dependent molecular chaperone HSC82

1

3

High-throughput

0.479

High

581827

SYKC
Lysine--tRNA ligase, cytoplasmic

1

6

High-throughput

0.479

High

600980

RL8A
Large ribosomal subunit protein eL8A

1

1

Small-scale

0.479

High

632858

IF2A
Eukaryotic translation initiation factor 2 subunit alpha

1

1

Small-scale

0.479

High

645295

XRN1
5'-3' exoribonuclease 1

1

1

High-throughput

0.479

High

655393

RS3A2
Small ribosomal subunit protein eS1B

1

2

Small-scale

0.479

High

657053

CDC48
Cell division control protein 48

1

3

High-throughput

0.479

High

657059

RL8B
Large ribosomal subunit protein eL8B

1

1

Small-scale

0.479

High

657061

EF2
Elongation factor 2

1

3

Small-scale

0.479

High

657064

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

1

1

Small-scale

0.479

High

657069

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.479

High

657071

SUI1
Eukaryotic translation initiation factor eIF-1

1

1

Small-scale

0.479

High

657072

PRS6A
26S proteasome regulatory subunit 6A

1

1

High-throughput

0.479

High

657074

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.479

High

657078

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

657079

SYG
Glycine--tRNA ligase 1, mitochondrial

1

4

High-throughput

0.479

High

657082

RS20
Small ribosomal subunit protein uS10

1

2

High-throughput

0.479

High

657083

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

6

High-throughput

0.479

High

657084

YHI0
Putative proline--tRNA ligase YHR020W

1

3

High-throughput

0.479

High

657086

SSZ1
Ribosome-associated complex subunit SSZ1

1

2

High-throughput

0.479

High

657088

RPN10
26S proteasome regulatory subunit RPN10

1

1

High-throughput

0.479

High

657090

MET30
F-box protein MET30

1

2

High-throughput

0.479

High

657091

RS14B
Small ribosomal subunit protein uS11B

1

1

Small-scale

0.479

High

657092

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.479

High

657110

RL4B
Large ribosomal subunit protein uL4B

1

2

Small-scale

0.479

High

657112

MCM6
DNA replication licensing factor MCM6

1

1

High-throughput

0.479

High

657113

EIF2A
Eukaryotic translation initiation factor 2A

1

2

High-throughput

0.479

High

657122

TOM1
E3 ubiquitin-protein ligase TOM1

1

2

High-throughput

0.479

High

657135

TYW1
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase

1

1

Small-scale

0.479

High

149597

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.458

High

383528

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.458

High

433459

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.458

High

434843

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

435785

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

504047

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.458

High

511540

RL44B
Large ribosomal subunit protein eL42B

1

0

High-throughput

0.458

High

512832

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.458

High

513632

RL2A
Large ribosomal subunit protein uL2A

1

0

Small-scale

0.458

High

657052

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

657054

SYLC
Leucine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

657055

RL16A
Large ribosomal subunit protein uL13A

1

0

High-throughput

0.458

High

657056

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

657060

HS104
Heat shock protein 104

1

0

High-throughput

0.458

High

657062

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

657066

CHD1
Chromo domain-containing protein 1

1

0

High-throughput

0.458

High

657070

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

657076

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

657080

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

0

Small-scale

0.458

High

657085

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.458

High

657095

TM108
Protein TMA108

1

0

High-throughput

0.458

High

657097

RLP7
Ribosome biogenesis protein RLP7

1

0

High-throughput

0.458

High

657103

RL17B
Large ribosomal subunit protein uL22B

1

0

Small-scale

0.458

High

657107

HOSC
Homocitrate synthase, cytosolic isozyme

1

0

High-throughput

0.458

High

657108

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

657114

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.458

High

657115

PESC
Pescadillo homolog

1

0

High-throughput

0.458

High

657117

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.458

High

657120

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

657121

RL6A
Large ribosomal subunit protein eL6A

1

0

Small-scale

0.458

High

657124

CLU
Clustered mitochondria protein 1

1

0

Small-scale

0.458

High

657126

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

0

Small-scale

0.458

High

657127

MYO5
Myosin-5

1

0

High-throughput

0.458

High

657131

SGO1
Shugoshin

1

0

High-throughput

0.458

High

657133

TIM18
Mitochondrial import inner membrane translocase subunit TIM18

1

0

High-throughput

0.458

High

657136

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.458

High

657138

KAD6
Adenylate kinase isoenzyme 6 homolog FAP7

1

0

Small-scale

0.458

High

657139

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

657142

CSN10
COP9 signalosome complex subunit 10

1

0

Small-scale

0.458

High

657123

GCN5
Histone acetyltransferase GCN5

1

3

High-throughput

0.445

High

657050

NAP1
Nucleosome assembly protein

1

0

High-throughput

0.438

High

657081

HSM3
DNA mismatch repair protein HSM3

1

0

High-throughput

0.438

High

657057

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

657105

MOG1
Nuclear import protein MOG1

1

1

High-throughput

0.437

High

657137

TRMB
tRNA

1

2

High-throughput

0.437

High

657075

PXA2
Peroxisomal long-chain fatty acid import protein 1

1

0

High-throughput

0.282

High

624969

PRP6
Pre-mRNA-splicing factor 6

1

0

High-throughput

0.279

Low

657068

KU70
ATP-dependent DNA helicase II subunit 1

1

0

High-throughput

0.279

Low

657094

MED3
Mediator of RNA polymerase II transcription subunit 3

1

0

High-throughput

0.269

Low

657118

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.269

Low

657132

RPN8
26S proteasome regulatory subunit RPN8

1

0

High-throughput

0.269

Low

657089

UME6
Transcriptional regulatory protein UME6

1

0

High-throughput

0.249

Low

657096

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

657125

RUVB1
RuvB-like protein 1

1

0

High-throughput

0.249

Low

657128

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

657134

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

657140

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025