HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: TESK2 (Q96S53)
Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2)
Gene: TESK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.621

Property	Details
Experiments	32707033, 22939624
Identification Methods	affinity chromatography technology, pull down, luminescence based mammalian interactome mapping, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 724 Hs			1 571
+	Hs
		432182 HS90A_HUMAN (1-724): 0: 1072: 85.25		TESK2_HUMAN (1-571): 5.03e-163: 478: 100.00
+	Hs
		438195 HS90B_HUMAN (1-724): 0: 1086: 100.00		TESK1_HUMAN (41-558): 1.25e-125: 384: 47.62
+	Hs
		431880 HS90A_HUMAN (1-724): 0: 1072: 85.25		TESK1_HUMAN (41-558): 1.25e-125: 384: 47.62
+	Hs
		438028 HS90B_HUMAN (1-724): 0: 1086: 100.00		EPHB1_HUMAN (4-371): 2.31e-115: 367: 23.76
+	Hs
		431691 HS90A_HUMAN (1-724): 0: 1072: 85.25		EPHB1_HUMAN (4-371): 2.31e-115: 367: 23.76
+	Hs
		438114 HS90B_HUMAN (1-724): 0: 1086: 100.00		MERTK_HUMAN (61-437): 2.75e-100: 327: 25.00
+	Hs
		431788 HS90A_HUMAN (1-724): 0: 1072: 85.25		MERTK_HUMAN (61-437): 2.75e-100: 327: 25.00
+	Hs
		438022 HS90B_HUMAN (1-724): 0: 1086: 100.00		LIMK1_HUMAN (62-312): 5.56e-66: 228: 44.40
+	Hs
		431683 HS90A_HUMAN (1-724): 0: 1072: 85.25		LIMK1_HUMAN (62-312): 5.56e-66: 228: 44.40
+	Hs
		438023 HS90B_HUMAN (1-724): 0: 1086: 100.00		LIMK2_HUMAN (62-318): 8.84e-61: 214: 40.86
+	Hs
		431684 HS90A_HUMAN (1-724): 0: 1072: 85.25		LIMK2_HUMAN (62-318): 8.84e-61: 214: 40.86
+	Hs
		538167 ENPL_HUMAN (3-693): 0: 917: 46.44		LIMK2_HUMAN (62-318): 8.84e-61: 214: 40.86
+	Hs
		1123435 H90B4_HUMAN (25-596): 0: 639: 71.85		TESK2_HUMAN (1-571): 5.03e-163: 478: 100.00
+	Hs
		1162521 Q6PK50_HUMAN (1-350): 0: 618: 99.71		TESK2_HUMAN (1-571): 5.03e-163: 478: 100.00
+	At
		287794 HS905_ARATH (1-724): 0: 885: 43.56		O82754_ARATH (62-324): 1.36e-29: 125: 34.78
+	Zm
		8229 A0A1D6LMW9_MAIZE (5-693): 0: 852: 46.66		A0A1D6ELX5_MAIZE (62-316): 9.8e-32: 132: 35.36
+	Hs
		863776 H90B4_HUMAN (25-596): 0: 639: 71.85		LIMK1_HUMAN (62-312): 5.56e-66: 228: 44.40
+	Hs
		863830 H90B4_HUMAN (25-596): 0: 639: 71.85		LIMK2_HUMAN (62-318): 8.84e-61: 214: 40.86