HitPredict

Interactor 1: CDC37 (Q16543)
Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]
Gene: CDC37

Interactor 2: KS6B2 (Q9UBS0)
Ribosomal protein S6 kinase beta-2 (S6K-beta-2) (S6K2) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 2) (P70S6K2) (p70-S6K 2) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14B) (p70 ribosomal S6 kinase beta) (S6K-beta) (p70 S6 kinase beta) (p70 S6K-beta) (p70 S6KB) (p70-beta)
Gene: RPS6KB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	25324306, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CDC37_M~Pkinase, CDC37_N~Pkinase
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 378 Hs			1 482
+	Hs
		682179 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		AKT2_HUMAN (26-391): 9.02e-155: 450: 41.24
+	Hs
		1083052 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		AKT3_HUMAN (6-391): 7.6e-154: 447: 39.85
+	Hs
		681873 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		AKT1_HUMAN (5-391): 6.01e-153: 445: 39.19
+	Hs
		566401 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		KPCA_HUMAN (9-401): 2.4e-148: 440: 35.82
+	Hs
		969088 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		KPCE_HUMAN (2-395): 2.02e-145: 435: 34.23
+	Hs
		568678 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		KAPCA_HUMAN (31-387): 1.3e-144: 419: 34.17
+	Dm
		954662 CDC37_DROME (1-351): 1.28e-126: 371: 52.54		P91656_DROME (43-480): 1.47e-159: 468: 62.33
+	Dm
		1096957 CDC37_DROME (1-351): 1.28e-126: 371: 52.54		Q94533_DROME (43-480): 1.84e-161: 467: 63.24
+	Hs
		1073425 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		KS6A1_HUMAN (5-380): 2.15e-105: 331: 25.19
+	Hs
		850660 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		KS6A3_HUMAN (5-380): 2.45e-105: 331: 26.85
+	Hs
		1071643 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		KS6A2_HUMAN (5-380): 5.48e-104: 328: 26.46
+	Hs
		1083040 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		KS6A6_HUMAN (4-332): 9.53e-101: 319: 25.51
+	Hs
		270419 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		KS6A5_HUMAN (2-325): 6.86e-97: 311: 23.32
+	Hs
		117008 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		SGK1_HUMAN (55-393): 4e-100: 308: 47.03
+	Hs
		1082911 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		SGK3_HUMAN (46-393): 3.33e-94: 295: 45.00
+	Hs
		272872 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		KS6A4_HUMAN (39-450): 2.95e-78: 261: 24.07