HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: M3K14 (Q99558)
Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa-beta-inducing kinase) (HsNIK) (Serine/threonine-protein kinase NIK)
Gene: MAP3K14

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.912

Property	Details
Experiments	31980649, 32707033, unassigned2173, 14743216, 22939624
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down, tandem affinity purification, luminescence based mammalian interactome mapping
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 947
+	Hs
		437928 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT2_HUMAN (286-701): 1.96e-133: 411: 20.32
+	Mm
		513660 HS90B_MOUSE (1-724): 0: 1089: 99.59		AKT1_MOUSE (286-713): 1.66e-131: 406: 20.22
+	Bt
		964601 HS90B_BOVIN (1-724): 0: 1085: 99.59		AKT1_BOVIN (286-713): 1.4e-132: 408: 19.33
+	Hs
		438633 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT3_HUMAN (272-705): 8.39e-132: 406: 19.01
+	Hs
		437927 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT1_HUMAN (286-713): 3.76e-131: 405: 19.33
+	Hs
		438551 HS90B_HUMAN (1-724): 0: 1086: 100.00		PAK6_HUMAN (70-672): 1.33e-125: 397: 17.46
+	Hs
		438123 HS90B_HUMAN (1-724): 0: 1086: 100.00		AAPK1_HUMAN (374-909): 2.62e-124: 390: 17.48
+	Hs
		437905 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6B1_HUMAN (341-818): 1.79e-124: 389: 18.20
+	Rn
		709234 HS90B_RAT (1-724): 0: 1089: 99.59		AAPK1_RAT (374-909): 5.75e-123: 386: 17.30
+	Hs
		437870 HS90B_HUMAN (1-724): 0: 1086: 100.00		KAPCA_HUMAN (361-691): 1.53e-122: 378: 20.46
+	Hs
		116958 HS90B_HUMAN (1-724): 0: 1086: 100.00		SGK1_HUMAN (354-729): 7.08e-116: 363: 21.19
+	Hs
		116956 HS90A_HUMAN (1-724): 0: 1072: 85.25		SGK1_HUMAN (354-729): 7.08e-116: 363: 21.19
+	Hs
		438011 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6A3_HUMAN (319-656): 2.54e-97: 324: 20.46
+	Hs
		438190 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6A2_HUMAN (319-657): 9e-97: 322: 21.49
+	Hs
		438193 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6A1_HUMAN (319-695): 1.9e-95: 318: 18.21
+	Hs
		438601 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6A6_HUMAN (305-712): 2.32e-93: 313: 17.70
+	Hs
		437961 HS90B_HUMAN (1-724): 0: 1086: 100.00		M3K8_HUMAN (379-647): 2.68e-29: 124: 30.66
+	Hs
		438130 HS90B_HUMAN (1-724): 0: 1086: 100.00		M3K1_HUMAN (370-643): 2.05e-24: 112: 30.52
+	Hs
		438643 HS90B_HUMAN (1-724): 0: 1086: 100.00		M3K2_HUMAN (386-626): 1.28e-24: 112: 33.60
+	Hs
		438469 HS90B_HUMAN (1-724): 0: 1086: 100.00		M3K3_HUMAN (373-612): 7.37e-23: 106: 32.14