HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: LATS2 (Q9NRM7)
Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase)
Gene: LATS2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	32707033, 20841485
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 1088
+	Hs
		325599 HS90B_HUMAN (1-724): 0: 1086: 100.00		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Hs
		438637 HS90B_HUMAN (1-724): 0: 1086: 100.00		ST38L_HUMAN (592-1051): 1.3e-146: 448: 41.30
+	Hs
		438188 HS90B_HUMAN (1-724): 0: 1086: 100.00		STK38_HUMAN (583-1065): 5.24e-146: 447: 40.58
+	Hs
		437928 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT2_HUMAN (532-1043): 1.88e-142: 438: 23.64
+	Mm
		513660 HS90B_MOUSE (1-724): 0: 1089: 99.59		AKT1_MOUSE (532-1043): 5.78e-141: 434: 22.16
+	Bt
		964601 HS90B_BOVIN (1-724): 0: 1085: 99.59		AKT1_BOVIN (532-1043): 2.11e-142: 438: 22.35
+	Hs
		437927 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT1_HUMAN (532-1043): 2.2e-141: 435: 22.16
+	Hs
		438633 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT3_HUMAN (532-1043): 3.66e-141: 435: 22.01
+	Hs
		438085 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPCE_HUMAN (554-1010): 1.06e-129: 413: 29.92
+	Hs
		437870 HS90B_HUMAN (1-724): 0: 1086: 100.00		KAPCA_HUMAN (635-1024): 1.31e-133: 410: 31.73
+	Hs
		437900 HS90B_HUMAN (1-724): 0: 1086: 100.00		KAPCB_HUMAN (638-1022): 1.92e-133: 410: 31.36
+	Hs
		116958 HS90B_HUMAN (1-724): 0: 1086: 100.00		SGK1_HUMAN (608-1042): 1.07e-131: 408: 28.51
+	Hs
		431511 HS90A_HUMAN (1-724): 0: 1072: 85.25		KAPCA_HUMAN (635-1024): 1.31e-133: 410: 31.73
+	Hs
		431538 HS90A_HUMAN (1-724): 0: 1072: 85.25		KAPCB_HUMAN (638-1022): 1.92e-133: 410: 31.36
+	Hs
		70435 HS90A_HUMAN (1-724): 0: 1072: 85.25		B2RB89_HUMAN (638-1022): 1.92e-133: 410: 31.36
+	Hs
		116956 HS90A_HUMAN (1-724): 0: 1072: 85.25		SGK1_HUMAN (608-1042): 1.07e-131: 408: 28.51
+	Hs
		438011 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6A3_HUMAN (519-990): 8.69e-81: 281: 19.63
+	Hs
		438193 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6A1_HUMAN (519-977): 1.47e-79: 277: 20.34
+	Hs
		438138 HS90B_HUMAN (1-724): 0: 1086: 100.00		ROCK1_HUMAN (640-1008): 1.28e-70: 260: 38.77
+	Hs
		438108 HS90B_HUMAN (1-724): 0: 1086: 100.00		DMPK_HUMAN (627-1007): 4.98e-66: 236: 35.90