Protein: TTHY
Transthyretin (ATTR) (Prealbumin) (TBPA)

Gene: TTHY, TTR
Organism: Homo sapiens
Interactions: 148
UniProt ID: P02766

Gene Ontology (top 5):
GO:0005179 - hormone activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0006144 - purine nucleobase metabolic process
GO:0035578 - azurophil granule lumen

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

363547

TTHY
Transthyretin

10

6

Small-scale

0.975

High

363375

RET4
Retinol-binding protein 4

3

1

Small-scale

0.866

High

363551

A4
Amyloid-beta precursor protein

4

1

Small-scale

0.689

High

363562

ATF4
Cyclic AMP-dependent transcription factor ATF-4

3

1

High-throughput

0.608

High

363582

NPC2
NPC intracellular cholesterol transporter 2

2

0

High-throughput

0.602

High

363556

VIME
Vimentin

2

0

High-throughput

0.594

High

363637

OTUB1
Ubiquitin thioesterase OTUB1

2

0

High-throughput

0.593

High

363566

MT3
Metallothionein-3

1

0

Small-scale

0.569

High

363644

FEZ1
Fasciculation and elongation protein zeta-1

2

1

High-throughput

0.566

High

363574

BAG6
Large proline-rich protein BAG6

2

0

Small-scale

0.561

High

363666

ATF5
Cyclic AMP-dependent transcription factor ATF-5

2

1

High-throughput

0.553

High

363585

PGBM
Basement membrane-specific heparan sulfate proteoglycan core protein

1

0

Small-scale

0.537

High

363564

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

1

High-throughput

0.536

High

363609

VWA1
von Willebrand factor A domain-containing protein 1

1

1

High-throughput

0.536

High

363567

MARK3
MAP/microtubule affinity-regulating kinase 3

1

0

High-throughput

0.518

High

363583

EF1A1
Elongation factor 1-alpha 1

1

0

High-throughput

0.518

High

363588

DDR1
Epithelial discoidin domain-containing receptor 1

1

0

High-throughput

0.518

High

363598

RAGE
Advanced glycosylation end product-specific receptor

1

0

Small-scale

0.513

High

126337

MATN2
Matrilin-2

1

0

High-throughput

0.513

High

311658

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

0

High-throughput

0.513

High

328091

SG1D1
Secretoglobin family 1D member 1

1

0

High-throughput

0.513

High

361284

APOA1
Apolipoprotein A-I

1

0

High-throughput

0.513

High

363548

ALBU
Albumin

1

0

High-throughput

0.513

High

363632

ITLN2
Intelectin-2

1

0

High-throughput

0.513

High

363555

TNR16
Tumor necrosis factor receptor superfamily member 16

1

1

High-throughput

0.508

High

363569

HNRH3
Heterogeneous nuclear ribonucleoprotein H3

1

1

High-throughput

0.494

High

305842

UBL3
Ubiquitin-like protein 3

1

0

High-throughput

0.493

High

363560

VATB1
V-type proton ATPase subunit B, kidney isoform

1

0

High-throughput

0.493

High

363565

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

0

High-throughput

0.493

High

363571

MNDA
Myeloid cell nuclear differentiation antigen

1

0

High-throughput

0.493

High

363584

H31
Histone H3.1

1

0

High-throughput

0.493

High

363587

KDSR
3-ketodihydrosphingosine reductase

1

0

High-throughput

0.493

High

363624

PALS1
Protein PALS1

1

0

High-throughput

0.493

High

363665

CLC11
C-type lectin domain family 11 member A

1

0

High-throughput

0.493

High

363596

I5P1
Inositol polyphosphate-5-phosphatase A

1

1

High-throughput

0.489

High

363605

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

1

High-throughput

0.489

High

363640

TSSK2
Testis-specific serine/threonine-protein kinase 2

1

1

High-throughput

0.489

High

363642

MTMR9
Myotubularin-related protein 9

1

1

High-throughput

0.489

High

363659

PHF11
PHD finger protein 11

1

1

High-throughput

0.489

High

363664

MTMR6
Myotubularin-related protein 6

1

1

High-throughput

0.489

High

210873

GET3
ATPase GET3

1

0

High-throughput

0.486

High

320459

CPNE6
Copine-6

1

0

High-throughput

0.486

High

344396

A2MG
Alpha-2-macroglobulin

1

0

High-throughput

0.486

High

363572

KPCI
Protein kinase C iota type

1

0

High-throughput

0.486

High

363577

F10A1
Hsc70-interacting protein

1

0

High-throughput

0.486

High

363581

ACTB
Actin, cytoplasmic 1

1

0

High-throughput

0.486

High

363612

TBA1A
Tubulin alpha-1A chain

1

0

High-throughput

0.486

High

363646

CAB45
45 kDa calcium-binding protein

1

0

High-throughput

0.486

High

363553

HS90A
Heat shock protein HSP 90-alpha

1

0

Small-scale

0.480

High

363557

CLUS
Clusterin

1

0

Small-scale

0.480

High

363606

OTU7B
OTU domain-containing protein 7B

1

1

High-throughput

0.470

High

363607

ESRP1
Epithelial splicing regulatory protein 1

1

1

High-throughput

0.470

High

363615

GP141
Probable G-protein coupled receptor 141

1

1

High-throughput

0.470

High

363647

WDR83
WD repeat domain-containing protein 83

1

1

High-throughput

0.470

High

363658

FEZ2
Fasciculation and elongation protein zeta-2

1

1

High-throughput

0.470

High

363579

SUMO3
Small ubiquitin-related modifier 3

1

2

High-throughput

0.464

High

363614

RAI1
Retinoic acid-induced protein 1

1

1

High-throughput

0.464

High

363653

SP110
Sp110 nuclear body protein

1

1

High-throughput

0.464

High

130687

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

0

High-throughput

0.458

High

351879

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.458

High

363552

CATB
Cathepsin B

1

0

Small-scale

0.458

High

363561

IL7RA
Interleukin-7 receptor subunit alpha

1

0

High-throughput

0.458

High

363578

TERA
Transitional endoplasmic reticulum ATPase

1

0

Small-scale

0.458

High

353605

IGHG1
Immunoglobulin heavy constant gamma 1

1

1

High-throughput

0.445

High

354021

IGHA1
Immunoglobulin heavy constant alpha 1

1

1

High-throughput

0.445

High

363590

SIAT6
CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase

1

0

High-throughput

0.438

High

363611

CREL2
Protein disulfide isomerase CRELD2

1

0

High-throughput

0.438

High

363592

FOXO1
Forkhead box protein O1

1

1

High-throughput

0.437

High

363617

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

1

Small-scale

0.437

High

363641

DERL3
Derlin-3

1

2

Small-scale

0.437

High

363649

DERL1
Derlin-1

1

2

Small-scale

0.437

High

363651

DERL2
Derlin-2

1

2

Small-scale

0.437

High

363549

TRFE
Serotransferrin

1

0

High-throughput

0.426

High

363550

PRIO
Major prion protein

1

0

High-throughput

0.426

High

363638

SNX27
Sorting nexin-27

2

0

High-throughput

0.328

High

363652

DDX31
ATP-dependent DNA helicase DDX31

2

0

High-throughput

0.328

High

305713

ELP1
Elongator complex protein 1

2

0

High-throughput

0.323

High

363593

CHD3
Chromodomain-helicase-DNA-binding protein 3

2

0

High-throughput

0.323

High

363597

SETB1
Histone-lysine N-methyltransferase SETDB1

2

0

High-throughput

0.323

High

363568

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

0

High-throughput

0.316

High

363601

NDUA5
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5

2

0

High-throughput

0.316

High

363586

CDR2
Cerebellar degeneration-related protein 2

1

0

High-throughput

0.299

High

363616

NECA2
N-terminal EF-hand calcium-binding protein 2

1

0

High-throughput

0.299

High

363559

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.282

High

363613

GET4
Golgi to ER traffic protein 4 homolog

1

0

High-throughput

0.282

High

363634

PHYIP
Phytanoyl-CoA hydroxylase-interacting protein

1

0

High-throughput

0.282

High

183008

P2RX6
P2X purinoceptor 6

1

0

High-throughput

0.279

Low

237638

SEP15
Selenoprotein F

1

0

High-throughput

0.279

Low

363563

CCNA2
Cyclin-A2

1

0

High-throughput

0.279

Low

363570

CCR1
C-C chemokine receptor type 1

1

0

High-throughput

0.279

Low

363599

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.279

Low

363608

SFXN4
Sideroflexin-4

1

0

High-throughput

0.279

Low

363620

CIR1
Corepressor interacting with RBPJ 1

1

0

High-throughput

0.279

Low

363626

S43A3
Equilibrative nucleobase transporter 1

1

0

High-throughput

0.279

Low

363629

RHBL4
Rhomboid-related protein 4

1

0

High-throughput

0.279

Low

363645

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

0

High-throughput

0.279

Low

363655

LANC2
LanC-like protein 2

1

0

High-throughput

0.279

Low

363660

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

0

High-throughput

0.279

Low

363671

FKBP7
Peptidyl-prolyl cis-trans isomerase FKBP7

1

0

High-throughput

0.279

Low

48004

TM129
E3 ubiquitin-protein ligase TM129

1

0

High-throughput

0.268

Low

274800

PALM
Paralemmin-1

1

0

High-throughput

0.268

Low

363558

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

0

High-throughput

0.268

Low

363573

VDAC2
Voltage-dependent anion-selective channel protein 2

1

0

High-throughput

0.268

Low

363580

VSX2
Visual system homeobox 2

1

0

High-throughput

0.268

Low

363589

BRME1
Break repair meiotic recombinase recruitment factor 1

1

0

High-throughput

0.268

Low

363591

KIF1A
Kinesin-like protein KIF1A

1

0

High-throughput

0.268

Low

363594

TDG
G/T mismatch-specific thymine DNA glycosylase

1

0

High-throughput

0.268

Low

363602

ZXDC
Zinc finger protein ZXDC

1

0

High-throughput

0.268

Low

363603

CP100
Cilia- and flagella-associated protein 100

1

0

High-throughput

0.268

Low

363604

F135B
Protein FAM135B

1

0

High-throughput

0.268

Low

363610

CNST
Consortin

1

0

High-throughput

0.268

Low

363618

ISCA2
Iron-sulfur cluster assembly 2 homolog, mitochondrial

1

0

High-throughput

0.268

Low

363619

Q86V28
AP-1 complex subunit gamma

1

0

High-throughput

0.268

Low

363621

UBR1
E3 ubiquitin-protein ligase UBR1

1

0

High-throughput

0.268

Low

363622

Q8IXS7
SRGAP3 protein

1

0

High-throughput

0.268

Low

363623

CCAR2
Cell cycle and apoptosis regulator protein 2

1

0

High-throughput

0.268

Low

363625

MET27
Methyltransferase-like protein 27

1

0

High-throughput

0.268

Low

363627

SUMF2
Inactive C-alpha-formylglycine-generating enzyme 2

1

0

High-throughput

0.268

Low

363628

NUP43
Nucleoporin Nup43

1

0

High-throughput

0.268

Low

363630

TB22A
TBC1 domain family member 22A

1

0

High-throughput

0.268

Low

363631

PRUN2
Protein prune homolog 2

1

0

High-throughput

0.268

Low

363635

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

0

High-throughput

0.268

Low

363636

RN183
E3 ubiquitin-protein ligase RNF183

1

0

High-throughput

0.268

Low

363639

COG8
Conserved oligomeric Golgi complex subunit 8

1

0

High-throughput

0.268

Low

363643

KCD15
BTB/POZ domain-containing protein KCTD15

1

0

High-throughput

0.268

Low

363650

SPY4
Protein sprouty homolog 4

1

0

High-throughput

0.268

Low

363654

ARFG3
ADP-ribosylation factor GTPase-activating protein 3

1

0

High-throughput

0.268

Low

363662

CSN3
COP9 signalosome complex subunit 3

1

0

High-throughput

0.268

Low

363667

KLH20
Kelch-like protein 20

1

0

High-throughput

0.268

Low

363668

CIA2B
Cytosolic iron-sulfur assembly component 2B

1

0

High-throughput

0.268

Low

363670

ASB3
Ankyrin repeat and SOCS box protein 3

1

0

High-throughput

0.268

Low

267730

TAF5L
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L

1

0

High-throughput

0.265

Low

330538

ZBED1
E3 SUMO-protein ligase ZBED1

1

0

High-throughput

0.265

Low

363575

SYQ
Glutamine--tRNA ligase

1

0

High-throughput

0.265

Low

363600

TAF1C
TATA box-binding protein-associated factor RNA polymerase I subunit C

1

0

High-throughput

0.265

Low

363648

INP5K
Inositol polyphosphate 5-phosphatase K

1

0

High-throughput

0.265

Low

363657

CE126
Centrosomal protein of 126 kDa

1

0

High-throughput

0.265

Low

363661

ERG28
Ergosterol biosynthetic protein 28 homolog

1

0

High-throughput

0.265

Low

363663

CTND2
Catenin delta-2

1

0

High-throughput

0.265

Low

363669

RN115
E3 ubiquitin-protein ligase RNF115

1

0

Small-scale

0.261

Low

363554

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

0

High-throughput

0.261

Low

100369

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

260446

PITX3
Pituitary homeobox 3

1

0

Small-scale

0.249

Low

363576

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.249

Low

363656

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.249

Low

363633

PI3R5
Phosphoinositide 3-kinase regulatory subunit 5

1

0

High-throughput

0.238

Low

363595

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024