HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: TBK1 (Q9UHD2)
Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1)
Gene: TBK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	36114006, 14743216, 22939624
Identification Methods	affinity chromatography technology, tandem affinity purification, luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 729
+	Hs
		432334 HS90A_HUMAN (1-724): 0: 1072: 85.25		TBK1_HUMAN (1-729): 0: 564: 100.00
+	Hs
		438164 HS90B_HUMAN (1-724): 0: 1086: 100.00		IKKE_HUMAN (1-716): 4.07e-146: 445: 48.33
+	Hs
		431843 HS90A_HUMAN (1-724): 0: 1072: 85.25		IKKE_HUMAN (1-716): 4.07e-146: 445: 48.33
+	Hs
		158374 HS90B_HUMAN (1-724): 0: 1086: 100.00		IKKB_HUMAN (9-727): 1.01e-139: 430: 18.98
+	Hs
		158371 HS90A_HUMAN (1-724): 0: 1072: 85.25		IKKB_HUMAN (9-727): 1.01e-139: 430: 18.98
+	Hs
		167449 HS90B_HUMAN (1-724): 0: 1086: 100.00		IKKA_HUMAN (9-637): 4.09e-121: 381: 21.08
+	Hs
		431932 HS90A_HUMAN (1-724): 0: 1072: 85.25		Q59GT1_HUMAN (9-637): 6.75e-123: 385: 21.08
+	Hs
		167446 HS90A_HUMAN (1-724): 0: 1072: 85.25		IKKA_HUMAN (9-637): 4.09e-121: 381: 21.08
+	Hs
		438381 HS90B_HUMAN (1-724): 0: 1086: 100.00		MK15_HUMAN (1-419): 3.82e-116: 362: 17.51
+	Hs
		437908 HS90B_HUMAN (1-724): 0: 1086: 100.00		CDK2_HUMAN (6-312): 1.71e-119: 361: 20.97
+	Hs
		438075 HS90B_HUMAN (1-724): 0: 1086: 100.00		CDK3_HUMAN (6-309): 7.85e-116: 352: 20.20
+	Hs
		432091 HS90A_HUMAN (1-724): 0: 1072: 85.25		MK15_HUMAN (1-419): 3.82e-116: 362: 17.51
+	Hs
		431549 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK2_HUMAN (6-312): 1.71e-119: 361: 20.97
+	Hs
		431741 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK3_HUMAN (6-309): 7.85e-116: 352: 20.20
+	Hs
		538107 ENPL_HUMAN (3-693): 0: 917: 46.44		CDK2_HUMAN (6-312): 1.71e-119: 361: 20.97
+	Hs
		262221 HS90B_HUMAN (1-724): 0: 1086: 100.00		ULK1_HUMAN (13-222): 2.86e-26: 117: 34.10
+	Hs
		438441 HS90B_HUMAN (1-724): 0: 1086: 100.00		KCC1G_HUMAN (9-221): 6.21e-24: 107: 34.27
+	Hs
		262219 HS90A_HUMAN (1-724): 0: 1072: 85.25		ULK1_HUMAN (13-222): 2.86e-26: 117: 34.10
+	Mm
		250790 HS90A_MOUSE (1-724): 0: 1068: 84.31		ULK1_MOUSE (13-222): 5.35e-26: 116: 33.64
+	Hs
		432166 HS90A_HUMAN (1-724): 0: 1072: 85.25		KCC1G_HUMAN (9-221): 6.21e-24: 107: 34.27