HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: MAST1 (Q9Y2H9)
Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase)
Gene: MAST1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.806

Property	Details
Experiments	31449053, 36199626
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0043025 - neuronal cell body
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 1570
+	Hs
		438270 HS90B_HUMAN (1-724): 0: 1086: 100.00		MAST2_HUMAN (13-1466): 0: 805: 61.72
+	Hs
		438138 HS90B_HUMAN (1-724): 0: 1086: 100.00		ROCK1_HUMAN (355-1490): 6.95e-159: 520: 14.99
+	Hs
		438131 HS90B_HUMAN (1-724): 0: 1086: 100.00		KGP2_HUMAN (22-688): 6.93e-155: 492: 21.14
+	Hs
		437869 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPCA_HUMAN (114-711): 3.63e-155: 490: 24.35
+	Mm
		513660 HS90B_MOUSE (1-724): 0: 1089: 99.59		AKT1_MOUSE (228-709): 1.16e-154: 481: 29.00
+	Hs
		408529 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPCB_HUMAN (114-711): 1.27e-152: 483: 24.02
+	Hs
		437928 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT2_HUMAN (227-709): 1.24e-155: 483: 28.80
+	Bt
		964601 HS90B_BOVIN (1-724): 0: 1085: 99.59		AKT1_BOVIN (228-709): 6.44e-156: 484: 29.00
+	Hs
		437927 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT1_HUMAN (228-709): 1.15e-154: 481: 28.60
+	Hs
		438633 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT3_HUMAN (228-709): 1.12e-151: 473: 29.00
+	Hs
		408527 HS90A_HUMAN (1-724): 0: 1072: 85.25		KPCB_HUMAN (114-711): 1.27e-152: 483: 24.02
+	Hs
		437905 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6B1_HUMAN (326-820): 1.15e-149: 469: 28.57
+	Hs
		438094 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPCT_HUMAN (251-716): 6.67e-145: 463: 28.69
+	Hs
		438108 HS90B_HUMAN (1-724): 0: 1086: 100.00		DMPK_HUMAN (372-891): 4.49e-142: 453: 30.17
+	Hs
		437870 HS90B_HUMAN (1-724): 0: 1086: 100.00		KAPCA_HUMAN (354-713): 7.15e-136: 425: 34.34
+	Hs
		437900 HS90B_HUMAN (1-724): 0: 1086: 100.00		KAPCB_HUMAN (354-713): 4.88e-134: 420: 33.79
+	Hs
		70435 HS90A_HUMAN (1-724): 0: 1072: 85.25		B2RB89_HUMAN (354-713): 4.88e-134: 420: 33.79
+	Hs
		437898 HS90B_HUMAN (1-724): 0: 1086: 100.00		KAPCG_HUMAN (365-713): 1.81e-62: 219: 33.99
+	Hs
		438637 HS90B_HUMAN (1-724): 0: 1086: 100.00		ST38L_HUMAN (370-676): 4.96e-61: 219: 36.17
+	Hs
		438188 HS90B_HUMAN (1-724): 0: 1086: 100.00		STK38_HUMAN (370-676): 3.21e-60: 216: 37.20