HitPredict

Interactor 1: CREB (P08368)
Transcriptional regulatory protein CreB
Gene: CREB

Interactor 2: CREC (P08401)
Sensor protein CreC (EC 2.7.13.3)
Gene: CREC

Species: Escherichia coli K-12

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.80	0.715

Property	Details
Experiments	24561554, 15522865
Identification Methods	two hybrid, affinity chromatography technology, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	HATPase_c~Response_reg, HisKA~Response_reg
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 229 Ec			1 474
+	Ec
		676783 BAER_ECOLI (3-228): 1.64e-75: 230: 40.71		BAES_ECOLI (10-471): 4.34e-74: 242: 17.02
+	Mx
		1091479 Q1DCL7_MYXXD (1-227): 2.2e-80: 241: 33.77		Q1D333_MYXXD (240-474): 1.38e-61: 209: 31.82
+	Ec
		465607 OMPR_ECOLI (2-228): 3.67e-75: 228: 32.76		ENVZ_ECOLI (24-474): 9.15e-67: 222: 17.84
+	Mx
		1091327 Q1D8M8_MYXXD (3-227): 7.11e-73: 223: 34.51		Q1CWW4_MYXXD (23-471): 3.62e-65: 225: 17.63
+	Ss
		937545 P72948_SYNY3 (4-227): 1.38e-79: 240: 38.53		Q55475_SYNY3 (179-471): 4.32e-61: 206: 25.97
+	Ec
		439475 PHOB_ECOLI (2-226): 1.54e-79: 239: 35.24		PHOR_ECOLI (200-473): 9.97e-60: 203: 21.86
+	Ss
		1122361 Q55942_SYNY3 (5-228): 6.23e-71: 218: 29.52		Q55941_SYNY3 (36-469): 5.57e-67: 223: 20.49
+	Mx
		1091248 Q1D1K9_MYXXD (2-227): 5.4e-73: 223: 34.51		Q1CVV2_MYXXD (245-469): 2.24e-59: 211: 23.18
+	Mx
		1091305 Q1D4T4_MYXXD (2-227): 6.32e-72: 220: 36.21		Q1CWQ1_MYXXD (55-474): 1.22e-60: 213: 16.15
+	Ss
		939460 P74626_SYNY3 (5-229): 5.39e-76: 230: 36.00		P74622_SYNY3 (229-472): 2.89e-61: 203: 22.00
+	Mx
		1091444 Q1D1K9_MYXXD (2-227): 5.4e-73: 223: 34.51		Q1D333_MYXXD (240-474): 1.38e-61: 209: 31.82
+	Mx
		1091475 Q1D8M8_MYXXD (3-227): 7.11e-73: 223: 34.51		Q1D333_MYXXD (240-474): 1.38e-61: 209: 31.82
+	Mx
		1091457 Q1D8M8_MYXXD (3-227): 7.11e-73: 223: 34.51		Q1D1W0_MYXXD (193-471): 1.36e-60: 207: 23.35
+	Mx
		1091496 Q1D4T4_MYXXD (2-227): 6.32e-72: 220: 36.21		Q1D4T3_MYXXD (74-470): 2.19e-61: 210: 23.45
+	Cv
		1308005 Q9ABD5_CAUVC (2-227): 3.68e-75: 228: 42.54		Q9ABD9_CAUVC (242-470): 5.11e-59: 202: 24.24
+	Mx
		1091452 Q1D4T4_MYXXD (2-227): 6.32e-72: 220: 36.21		Q1D1W0_MYXXD (193-471): 1.36e-60: 207: 23.35
+	Mx
		1091500 Q1D4T4_MYXXD (2-227): 6.32e-72: 220: 36.21		Q1D8M1_MYXXD (256-471): 2.22e-57: 206: 29.28
+	Mx
		1091414 Q1D1K9_MYXXD (2-227): 5.4e-73: 223: 34.51		Q1D0A1_MYXXD (263-462): 7.28e-13: 72.4: 26.87
+	Mx
		1091420 Q1D8M8_MYXXD (3-227): 7.11e-73: 223: 34.51		Q1D0A1_MYXXD (263-462): 7.28e-13: 72.4: 26.87
+	Ec
		602045 KDPE_ECOLI (5-226): 6.91e-71: 217: 35.59		KDPD_ECOLI (239-462): 2.05e-12: 71.6: 28.75