Protein: ILVB
Acetolactate synthase catalytic subunit, mitochondrial (EC 2.2.1.6) (Acetohydroxy-acid synthase catalytic subunit) (AHAS) (ALS)

Gene: ILVB, ILV2
Organism: Saccharomyces cerevisiae S288C
Interactions: 197
UniProt ID: P07342

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0003984 - acetolactate synthase activity
GO:0005739 - mitochondrion
GO:0005948 - acetolactate synthase complex
GO:0009082 - branched-chain amino acid biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

456344

ILV6
Acetolactate synthase small subunit, mitochondrial

4

4

Small-scale

0.899

High

456337

SIS1
Protein SIS1

3

3

High-throughput

0.587

High

456309

HSP77
Import motor subunit, mitochondrial

2

4

High-throughput

0.584

High

456325

MDHM
Malate dehydrogenase, mitochondrial

2

1

Small-scale

0.584

High

456411

SSB2
Ribosome-associated molecular chaperone SSB2

3

9

High-throughput

0.579

High

456303

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

16

Small-scale

0.575

High

368108

THDH
Threonine dehydratase, mitochondrial

2

1

High-throughput

0.571

High

456322

HSC82
ATP-dependent molecular chaperone HSC82

2

8

High-throughput

0.571

High

439064

ILV5
Ketol-acid reductoisomerase, mitochondrial

2

0

High-throughput

0.559

High

456315

HSP72
Heat shock protein SSA2

2

10

High-throughput

0.552

High

456388

GBLP
Small ribosomal subunit protein RACK1

2

1

High-throughput

0.543

High

456437

BRE5
UBP3-associated protein BRE5

1

1

High-throughput

0.536

High

456442

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

High-throughput

0.536

High

392027

HSP82
ATP-dependent molecular chaperone HSP82

2

8

High-throughput

0.533

High

434702

RS3
Small ribosomal subunit protein uS3

2

2

High-throughput

0.521

High

456372

RSSA1
Small ribosomal subunit protein uS2A

2

6

High-throughput

0.521

High

456314

HSP71
Heat shock protein SSA1

2

10

High-throughput

0.504

High

456318

SSB1
Ribosome-associated molecular chaperone SSB1

2

9

High-throughput

0.504

High

456364

EI2BB
Translation initiation factor eIF2B subunit beta

1

3

High-throughput

0.500

High

456378

DHE2
NAD-specific glutamate dehydrogenase

1

0

High-throughput

0.493

High

456438

TEP1
Probable phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TEP1

1

1

High-throughput

0.489

High

456453

KU80
ATP-dependent DNA helicase II subunit 2

1

1

High-throughput

0.489

High

366888

ATPB
ATP synthase subunit beta, mitochondrial

1

3

High-throughput

0.479

High

456312

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.479

High

456326

ACON
Aconitate hydratase, mitochondrial

1

2

High-throughput

0.479

High

456327

HSP60
Heat shock protein 60, mitochondrial

1

4

High-throughput

0.479

High

456329

ODO1
2-oxoglutarate dehydrogenase, mitochondrial

1

2

High-throughput

0.479

High

456340

STDH
Catabolic L-serine/threonine dehydratase [Includes: L-serine dehydratase

1

1

High-throughput

0.479

High

456346

CDC48
Cell division control protein 48

1

3

High-throughput

0.479

High

456349

KAD3
GTP:AMP phosphotransferase, mitochondrial

1

1

High-throughput

0.479

High

456354

IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

1

2

High-throughput

0.479

High

456379

HSP78
Heat shock protein 78, mitochondrial

1

5

High-throughput

0.479

High

456389

ETR1
Enoyl-[acyl-carrier-protein] reductase, mitochondrial

1

1

High-throughput

0.479

High

456404

SYPM
Probable proline--tRNA ligase, mitochondrial

1

2

High-throughput

0.479

High

456408

ALDH5
Aldehyde dehydrogenase 5, mitochondrial

1

2

High-throughput

0.479

High

456421

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

2

High-throughput

0.479

High

456422

DLD2
D-2-hydroxyglutarate--pyruvate transhydrogenase DLD2

1

2

High-throughput

0.479

High

456431

LYS4
Homoaconitase, mitochondrial

1

2

High-throughput

0.479

High

456441

NUM1
Nuclear migration protein NUM1

1

1

High-throughput

0.479

High

456449

RT10
Small ribosomal subunit protein uS10m

1

2

High-throughput

0.479

High

456465

NEW1
[NU+] prion formation protein 1

1

2

High-throughput

0.479

High

456472

RM23
Large ribosomal subunit protein uL13m

1

1

High-throughput

0.479

High

456475

SMC6
Structural maintenance of chromosomes protein 6

1

1

High-throughput

0.479

High

456304

ARD1
N-terminal acetyltransferase A complex catalytic subunit ARD1

1

1

High-throughput

0.470

High

456474

YP247
WD repeat-containing protein YPL247C

1

2

High-throughput

0.470

High

416992

VDAC1
Non-selective voltage-gated ion channel 1

1

0

Small-scale

0.458

High

452609

ADH3
Alcohol dehydrogenase 3, mitochondrial

1

0

High-throughput

0.458

High

453233

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

0

High-throughput

0.458

High

456317

RT02
Small ribosomal subunit protein uS14m

1

0

High-throughput

0.458

High

456324

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

1

0

High-throughput

0.458

High

456330

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

0

High-throughput

0.458

High

456335

AIM17
Probable oxidoreductase AIM17

1

0

High-throughput

0.458

High

456345

IMG1
Large ribosomal subunit protein bL19m

1

0

High-throughput

0.458

High

456353

COQ3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial

1

0

High-throughput

0.458

High

456355

RT06
Small ribosomal subunit protein bS6m

1

0

High-throughput

0.458

High

456361

RIM1
Single-stranded DNA-binding protein RIM1, mitochondrial

1

0

High-throughput

0.458

High

456369

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

0

High-throughput

0.458

High

456370

PREP
Presequence protease, mitochondrial

1

0

High-throughput

0.458

High

456371

RM06
Large ribosomal subunit protein uL6m

1

0

High-throughput

0.458

High

456382

RM38
Large ribosomal subunit protein uL14m

1

0

High-throughput

0.458

High

456384

PMIP
Mitochondrial intermediate peptidase

1

0

High-throughput

0.458

High

456385

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.458

High

456387

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.458

High

456390

PANB
3-methyl-2-oxobutanoate hydroxymethyltransferase

1

0

High-throughput

0.458

High

456392

GRPE
GrpE protein homolog, mitochondrial

1

0

High-throughput

0.458

High

456396

BCA1
Branched-chain-amino-acid aminotransferase, mitochondrial

1

0

High-throughput

0.458

High

456399

ILV3
Dihydroxy-acid dehydratase, mitochondrial

1

0

High-throughput

0.458

High

456409

AIM9
Altered inheritance of mitochondria protein 9, mitochondrial

1

0

High-throughput

0.458

High

456410

FMP10
Uncharacterized mitochondrial membrane protein FMP10

1

0

High-throughput

0.458

High

456413

COQ7
5-demethoxyubiquinone hydroxylase, mitochondrial

1

0

High-throughput

0.458

High

456419

RT18
Small ribosomal subunit protein uS11m

1

0

High-throughput

0.458

High

456420

ETFB
Probable electron transfer flavoprotein subunit beta

1

0

High-throughput

0.458

High

456425

CAF17
Iron-sulfur cluster assembly factor IBA57, mitochondrial

1

0

High-throughput

0.458

High

456426

GCST
Aminomethyltransferase, mitochondrial

1

0

High-throughput

0.458

High

456429

COQ5
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

1

0

High-throughput

0.458

High

456430

TOM22
Mitochondrial import receptor subunit TOM22

1

0

High-throughput

0.458

High

456432

ALAT1
Alanine aminotransferase, mitochondrial

1

0

High-throughput

0.458

High

456445

GLRX5
Monothiol glutaredoxin-5, mitochondrial

1

0

High-throughput

0.458

High

456446

RT51
Small ribosomal subunit protein bS1m

1

0

High-throughput

0.458

High

456447

ESP1
Separin

1

0

High-throughput

0.458

High

456448

ISU1
Iron sulfur cluster assembly protein 1, mitochondrial

1

0

High-throughput

0.458

High

456455

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

0

High-throughput

0.458

High

456458

RM35
Large ribosomal subunit protein mL38

1

0

High-throughput

0.458

High

456463

ETFD
Probable electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial

1

0

High-throughput

0.458

High

456467

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

456471

ETFA
Probable electron transfer flavoprotein subunit alpha, mitochondrial

1

0

High-throughput

0.458

High

456313

SSBP1
Single-stranded nucleic acid-binding protein

1

1

High-throughput

0.457

High

456319

EI2BD
Translation initiation factor eIF2B subunit delta

1

3

High-throughput

0.457

High

456328

PP11
Serine/threonine-protein phosphatase PP1-1

1

1

High-throughput

0.457

High

456331

MDHC
Malate dehydrogenase, cytoplasmic

1

1

High-throughput

0.457

High

456336

MEK1
Meiosis-specific serine/threonine-protein kinase MEK1

1

2

High-throughput

0.457

High

456338

CDC10
Cell division control protein 10

1

1

High-throughput

0.457

High

456339

RV161
Reduced viability upon starvation protein 161

1

2

High-throughput

0.457

High

456342

DMC1
Meiotic recombination protein DMC1

1

2

High-throughput

0.457

High

456350

PPZ1
Serine/threonine-protein phosphatase PP-Z1

1

4

High-throughput

0.457

High

456360

ARP2
Actin-related protein 2

1

1

High-throughput

0.457

High

456363

MKK2
MAP kinase kinase MKK2/SSP33

1

1

High-throughput

0.457

High

456365

RPD3
Histone deacetylase RPD3

1

1

Small-scale

0.457

High

456377

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

2

High-throughput

0.457

High

456391

IMB2
Importin subunit beta-2

1

2

High-throughput

0.457

High

456397

PEX7
Peroxisomal targeting signal 2 receptor

1

2

High-throughput

0.457

High

456403

SLN1
Osmosensing histidine protein kinase SLN1

1

1

High-throughput

0.457

High

456415

COPB2
Coatomer subunit beta'

1

4

High-throughput

0.457

High

456433

SEH1
Nucleoporin SEH1

1

3

High-throughput

0.457

High

456435

SSK2
MAP kinase kinase kinase SSK2

1

2

High-throughput

0.457

High

456436

COPA
Coatomer subunit alpha

1

4

High-throughput

0.457

High

456451

WDR59
Maintenance of telomere capping protein 5

1

5

High-throughput

0.457

High

456454

SPC24
Kinetochore protein SPC24

1

1

High-throughput

0.457

High

456456

CIAO1
Cytosolic iron-sulfur protein assembly protein 1

1

2

High-throughput

0.457

High

456473

SKS1
Serine/threonine-protein kinase SKS1

1

1

High-throughput

0.457

High

456476

AP2M
AP-2 complex subunit mu

1

2

High-throughput

0.457

High

364875

KPYK1
Pyruvate kinase 1

1

1

High-throughput

0.445

High

394118

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.445

High

453354

PYR1
Multifunctional protein URA2

1

1

High-throughput

0.445

High

456305

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

2

High-throughput

0.445

High

456332

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

2

High-throughput

0.445

High

456374

UFD4
Ubiquitin fusion degradation protein 4

1

2

High-throughput

0.445

High

456381

GCN1
eIF-2-alpha kinase activator GCN1

1

1

High-throughput

0.445

High

456386

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

2

High-throughput

0.445

High

456406

HSP7E
Heat shock protein SSC3, mitochondrial

1

4

High-throughput

0.445

High

456466

MDN1
Midasin

1

1

High-throughput

0.445

High

456333

SAN1
Protein SAN1

1

1

Small-scale

0.439

High

149492

RS9A
Small ribosomal subunit protein uS4A

1

2

High-throughput

0.437

High

383421

RS17A
Small ribosomal subunit protein eS17A

1

1

High-throughput

0.437

High

409843

RL25
Large ribosomal subunit protein uL23

1

1

High-throughput

0.437

High

430740

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

2

Small-scale

0.437

High

433350

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.437

High

435673

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.437

High

441610

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.437

High

454775

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.437

High

456307

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

456308

RL31A
Large ribosomal subunit protein eL31A

1

2

High-throughput

0.437

High

456310

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.437

High

456311

RS8A
Small ribosomal subunit protein eS8A

1

2

High-throughput

0.437

High

456320

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.437

High

456341

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.437

High

456352

RS7A
Small ribosomal subunit protein eS7A

1

2

High-throughput

0.437

High

456356

TF2B
Transcription initiation factor IIB

1

5

High-throughput

0.437

High

456362

HOG1
Mitogen-activated protein kinase HOG1

1

1

High-throughput

0.437

High

456373

SMY2
Protein SMY2

1

2

High-throughput

0.437

High

456380

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.437

High

456383

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.437

High

456393

RS20
Small ribosomal subunit protein uS10

1

2

High-throughput

0.437

High

456398

DHH1
ATP-dependent RNA helicase DHH1

1

1

High-throughput

0.437

High

456400

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

456407

ARB1
ABC transporter ATP-binding protein ARB1

1

1

Small-scale

0.437

High

456412

RLP7
Ribosome biogenesis protein RLP7

1

2

High-throughput

0.437

High

456423

MPS3
Spindle pole body assembly component MPS3

1

4

High-throughput

0.437

High

456424

MOG1
Nuclear import protein MOG1

1

1

High-throughput

0.437

High

456427

RS12
Small ribosomal subunit protein eS12

1

2

High-throughput

0.437

High

456428

VATG
V-type proton ATPase subunit G

1

1

High-throughput

0.437

High

456434

PESC
Pescadillo homolog

1

1

High-throughput

0.437

High

456443

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.437

High

456444

MLP1
Protein MLP1

1

2

High-throughput

0.437

High

456462

RS10A
Small ribosomal subunit protein eS10A

1

2

High-throughput

0.437

High

456464

AP3D
AP-3 complex subunit delta

1

4

High-throughput

0.437

High

456470

DBP10
ATP-dependent RNA helicase DBP10

1

3

High-throughput

0.437

High

450490

FAS1
Fatty acid synthase subunit beta

1

0

High-throughput

0.426

High

456401

MET10
Sulfite reductase [NADPH] flavoprotein component

1

0

High-throughput

0.426

High

456440

DNM1
Dynamin-related protein DNM1

1

0

High-throughput

0.426

High

386522

TBB
Tubulin beta chain

1

1

High-throughput

0.407

High

456316

METK1
S-adenosylmethionine synthase 1

1

1

High-throughput

0.407

High

456323

VATB
V-type proton ATPase subunit B

1

3

High-throughput

0.407

High

456357

HS104
Heat shock protein 104

1

5

High-throughput

0.407

High

456366

RPN2
26S proteasome regulatory subunit RPN2

1

3

High-throughput

0.407

High

456367

HSP7F
Heat shock protein homolog SSE1

1

16

High-throughput

0.407

High

456368

HSP79
Heat shock protein homolog SSE2

1

16

High-throughput

0.407

High

456376

PRS7
26S proteasome regulatory subunit 7 homolog

1

4

High-throughput

0.407

High

456394

YHI0
Putative proline--tRNA ligase YHR020W

1

1

High-throughput

0.407

High

456395

RPN1
26S proteasome regulatory subunit RPN1

1

3

High-throughput

0.407

High

456417

MPG1
Mannose-1-phosphate guanyltransferase

1

4

High-throughput

0.407

High

456418

EMW1
Essential for maintenance of the cell wall protein 1

1

1

High-throughput

0.407

High

456468

RAD59
DNA repair protein RAD59

1

0

High-throughput

0.279

Low

456334

UBA1
Ubiquitin-activating enzyme E1 1

1

0

High-throughput

0.269

Low

456459

PEX19
Peroxisomal membrane protein import receptor PEX19

1

0

High-throughput

0.269

Low

456405

HAT2
Histone acetyltransferase type B subunit 2

1

0

High-throughput

0.261

Low

456469

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.261

Low

456343

SGF29
SAGA complex subunit SGF29

1

0

Small-scale

0.249

Low

456347

SPB4
ATP-dependent rRNA helicase SPB4

1

0

High-throughput

0.249

Low

456359

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.249

Low

456416

MID1
Stretch-activated cation channel MID1

1

0

Small-scale

0.249

Low

456439

ORC1
Origin recognition complex subunit 1

1

0

High-throughput

0.249

Low

456452

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

0

High-throughput

0.249

Low

456457

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

456460

YD053
Putative uncharacterized protein YDR053W

1

0

High-throughput

0.249

Low

456461

MCA1
Metacaspase-1

1

0

High-throughput

0.249

Low

427075

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.232

Low

456306

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.232

Low

456321

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

0

High-throughput

0.232

Low

456348

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.232

Low

456351

RS5
Small ribosomal subunit protein uS7

1

0

High-throughput

0.232

Low

456358

EF2
Elongation factor 2

1

0

High-throughput

0.232

Low

456375

PRS6B
26S proteasome regulatory subunit 6B homolog

1

0

High-throughput

0.232

Low

456402

NPR2
Nitrogen permease regulator 2

1

0

High-throughput

0.232

Low

456414

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.232

Low

456450

CLU
Clustered mitochondria protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025