HitPredict

Interactor 1: ODPA (P08559)
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I)
Gene: PDHA1

Interactor 2: MDHM (P40926)
Malate dehydrogenase, mitochondrial (EC 1.1.1.37)
Gene: MDH2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	32877691, 29128334, 34079125
Identification Methods	proximity labelling technology, affinity chromatography technology, cross-linking study
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005739 - mitochondrion GO:0005759 - mitochondrial matrix GO:0006099 - tricarboxylic acid cycle
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 390 Hs			1 338
+	Hs
		440585 ODPA_HUMAN (1-390): 4.58e-177: 499: 100.00		LDH6A_HUMAN (5-333): 3.41e-119: 348: 20.70
+	Hs
		777545 ODO1_HUMAN (2-366): 2.85e-125: 387: 14.75		MDHM_HUMAN (1-338): 1.83e-137: 395: 100.00
+	Hs
		777787 OGDHL_HUMAN (5-366): 9.61e-123: 380: 13.10		MDHM_HUMAN (1-338): 1.83e-137: 395: 100.00
+	Sc
		558552 ODPA_YEAST (42-383): 1.18e-149: 431: 52.01		MDHM_YEAST (9-336): 3.38e-113: 333: 53.15