Protein: HCK
Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck)

Gene: HCK
Organism: Homo sapiens
Interactions: 179
UniProt ID: P08631

Gene Ontology (top 5):
GO:0001784 - phosphotyrosine residue binding
GO:0002522 - leukocyte migration involved in immune response
GO:0002758 - innate immune response-activating signaling pathway
GO:0002862 - negative regulation of inflammatory response to antigenic stimulus
GO:0004713 - protein tyrosine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

461050

HS90A
Heat shock protein HSP 90-alpha

4

20

High-throughput

0.881

High

467980

HS90B
Heat shock protein HSP 90-beta

4

20

High-throughput

0.881

High

473427

CDC37
Hsp90 co-chaperone Cdc37

4

14

Small-scale

0.881

High

362630

EGFR
Epidermal growth factor receptor

3

20

High-throughput

0.843

High

463286

LYN
Tyrosine-protein kinase Lyn

3

20

High-throughput

0.839

High

473453

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

19

High-throughput

0.819

High

473401

FAK1
Focal adhesion kinase 1

2

20

High-throughput

0.811

High

473402

BTK
Tyrosine-protein kinase BTK

2

19

Small-scale

0.799

High

473361

SRC
Proto-oncogene tyrosine-protein kinase Src

2

20

Small-scale

0.789

High

154416

SH2B2
SH2B adapter protein 2

2

19

High-throughput

0.783

High

473429

PKHG4
Puratrophin-1

2

12

High-throughput

0.783

High

473368

ERBB3
Receptor tyrosine-protein kinase erbB-3

2

20

High-throughput

0.778

High

473406

ACK1
Activated CDC42 kinase 1

2

19

Small-scale

0.778

High

473458

SH3K1
SH3 domain-containing kinase-binding protein 1

2

20

Small-scale

0.776

High

473405

SOS1
Son of sevenless homolog 1

2

20

Small-scale

0.768

High

473483

ASAP1
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

2

15

Small-scale

0.768

High

473443

NGEF
Ephexin-1

2

19

High-throughput

0.767

High

286754

SKAP2
Src kinase-associated phosphoprotein 2

2

20

Small-scale

0.757

High

362129

ABL1
Tyrosine-protein kinase ABL1

2

18

Small-scale

0.754

High

473357

BCR
Breakpoint cluster region protein

2

19

Small-scale

0.754

High

186685

P73
Tumor protein p73

1

5

Small-scale

0.747

High

473411

PAK2
Serine/threonine-protein kinase PAK 2

1

18

Small-scale

0.747

High

473417

GRB14
Growth factor receptor-bound protein 14

2

20

High-throughput

0.743

High

473384

CDK9
Cyclin-dependent kinase 9

2

19

High-throughput

0.737

High

473423

RBP1
RalA-binding protein 1

2

20

High-throughput

0.737

High

473366

RASA1
Ras GTPase-activating protein 1

1

20

Small-scale

0.724

High

473419

RASA3
Ras GTPase-activating protein 3

1

20

Small-scale

0.724

High

473464

CSF3R
Granulocyte colony-stimulating factor receptor

1

14

Small-scale

0.724

High

473404

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

5

20

Small-scale

0.713

High

473482

TRIM1
Probable E3 ubiquitin-protein ligase MID2

2

15

High-throughput

0.700

High

473369

CBL
E3 ubiquitin-protein ligase CBL

4

20

Small-scale

0.698

High

473378

ABL2
Tyrosine-protein kinase ABL2

1

19

High-throughput

0.698

High

473486

M4K5
Mitogen-activated protein kinase kinase kinase kinase 5

1

20

High-throughput

0.698

High

471958

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.692

High

473354

KIT
Mast/stem cell growth factor receptor Kit

1

20

High-throughput

0.692

High

473414

GAB1
GRB2-associated-binding protein 1

1

20

High-throughput

0.692

High

168616

CSKP
Peripheral plasma membrane protein CASK

1

20

High-throughput

0.691

High

210169

IRAK2
Interleukin-1 receptor-associated kinase-like 2

1

3

High-throughput

0.691

High

439912

LCK
Tyrosine-protein kinase Lck

1

19

High-throughput

0.691

High

473469

STK33
Serine/threonine-protein kinase 33

1

9

High-throughput

0.691

High

473413

ADA15
Disintegrin and metalloproteinase domain-containing protein 15

3

20

Small-scale

0.680

High

473392

KR109
Keratin-associated protein 10-9

3

9

High-throughput

0.675

High

473432

MTUS2
Microtubule-associated tumor suppressor candidate 2

3

17

High-throughput

0.675

High

473435

K1C40
Keratin, type I cytoskeletal 40

3

9

High-throughput

0.675

High

473476

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

3

13

High-throughput

0.675

High

410540

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.647

High

473377

STAT3
Signal transducer and activator of transcription 3

1

16

Small-scale

0.647

High

473388

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

20

Small-scale

0.647

High

473422

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

473442

ABI1
Abl interactor 1

1

20

Small-scale

0.647

High

473465

DOK1
Docking protein 1

1

20

Small-scale

0.647

High

473380

WASP
Actin nucleation-promoting factor WAS

2

20

Small-scale

0.639

High

473450

PDC6I
Programmed cell death 6-interacting protein

2

17

Small-scale

0.636

High

473439

NT2NA
Notch homolog 2 N-terminal-like protein A

2

9

High-throughput

0.633

High

220217

FRS3
Fibroblast growth factor receptor substrate 3

2

20

High-throughput

0.628

High

473447

OLIG1
Oligodendrocyte transcription factor 1

2

1

High-throughput

0.628

High

136264

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

20

Small-scale

0.618

High

473348

HCK
Tyrosine-protein kinase HCK

1

19

High-throughput

0.618

High

473371

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

20

Small-scale

0.618

High

473374

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

20

Small-scale

0.618

High

473376

IL6RB
Interleukin-6 receptor subunit beta

1

20

Small-scale

0.618

High

473383

DYN2
Dynamin-2

1

11

Small-scale

0.618

High

473410

LCP2
Lymphocyte cytosolic protein 2

1

20

Small-scale

0.618

High

473456

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

20

Small-scale

0.618

High

473478

ANLN
Anillin

1

5

High-throughput

0.618

High

473485

3BP1
SH3 domain-binding protein 1

1

20

Small-scale

0.618

High

473487

CD2AP
CD2-associated protein

1

20

Small-scale

0.618

High

64523

CC88B
Coiled-coil domain-containing protein 88B

2

10

High-throughput

0.606

High

269144

HSF2B
Heat shock factor 2-binding protein

2

1

High-throughput

0.606

High

300284

KRT34
Keratin, type I cuticular Ha4

2

9

High-throughput

0.606

High

300546

KRT36
Keratin, type I cuticular Ha6

2

7

High-throughput

0.606

High

352869

AGR2
Anterior gradient protein 2 homolog

2

1

High-throughput

0.606

High

473362

TRI27
Zinc finger protein RFP

2

8

High-throughput

0.606

High

473390

KR107
Keratin-associated protein 10-7

2

9

High-throughput

0.606

High

473391

KR108
Keratin-associated protein 10-8

2

7

High-throughput

0.606

High

473403

KRA11
Keratin-associated protein 1-1

2

6

High-throughput

0.606

High

473409

MKRN3
E3 ubiquitin-protein ligase makorin-3

2

1

High-throughput

0.606

High

473424

K1H1
Keratin, type I cuticular Ha1

2

10

High-throughput

0.606

High

473426

TRIP6
Thyroid receptor-interacting protein 6

2

20

High-throughput

0.606

High

473434

FHL5
Four and a half LIM domains protein 5

2

20

High-throughput

0.606

High

473441

KRA13
Keratin-associated protein 1-3

2

6

High-throughput

0.606

High

473445

ZSCA4
Zinc finger and SCAN domain-containing protein 4

2

1

High-throughput

0.606

High

473454

KRT35
Keratin, type I cuticular Ha5

2

10

High-throughput

0.606

High

473462

TOX2
TOX high mobility group box family member 2

2

5

High-throughput

0.606

High

473367

MK
Midkine

2

0

High-throughput

0.580

High

473407

INCA1
Protein INCA1

2

0

High-throughput

0.580

High

473433

KPRP
Keratinocyte proline-rich protein

2

0

High-throughput

0.580

High

473451

TEKT4
Tektin-4

2

0

High-throughput

0.580

High

473457

RBPMS
RNA-binding protein with multiple splicing

2

0

High-throughput

0.580

High

473461

AP4AT
AP-4 complex accessory subunit Tepsin

2

0

High-throughput

0.580

High

473468

KRA31
Keratin-associated protein 3-1

2

0

High-throughput

0.580

High

473477

BPIA1
BPI fold-containing family A member 1

2

0

High-throughput

0.580

High

473430

H90B3
Putative heat shock protein HSP 90-beta-3

1

20

High-throughput

0.575

High

473431

H90B2
Putative heat shock protein HSP 90-beta 2

1

20

High-throughput

0.575

High

473415

RPGF1
Rap guanine nucleotide exchange factor 1

1

14

Small-scale

0.573

High

191516

MAGB2
Melanoma-associated antigen B2

2

3

High-throughput

0.571

High

256569

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

2

12

High-throughput

0.571

High

346815

BAG2
BAG family molecular chaperone regulator 2

2

3

High-throughput

0.571

High

415285

HSPB1
Heat shock protein beta-1

2

6

High-throughput

0.571

High

462203

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

2

13

High-throughput

0.571

High

473355

BIP
Endoplasmic reticulum chaperone BiP

2

17

High-throughput

0.571

High

473356

HSP7C
Heat shock cognate 71 kDa protein

2

11

High-throughput

0.571

High

473358

PRPS2
Ribose-phosphate pyrophosphokinase 2

2

11

High-throughput

0.571

High

473364

HSP76
Heat shock 70 kDa protein 6

2

11

High-throughput

0.571

High

473372

RL22
Large ribosomal subunit protein eL22

2

1

High-throughput

0.571

High

473375

HSPA9
Stress-70 protein, mitochondrial

2

20

High-throughput

0.571

High

473385

FXR1
RNA-binding protein FXR1

2

5

High-throughput

0.571

High

473394

PRPS1
Ribose-phosphate pyrophosphokinase 1

2

11

High-throughput

0.571

High

473395

RL37
Large ribosomal subunit protein eL37

2

1

High-throughput

0.571

High

473399

AKA12
A-kinase anchor protein 12

2

10

High-throughput

0.571

High

473408

CHD3
Chromodomain-helicase-DNA-binding protein 3

2

6

High-throughput

0.571

High

473420

CHD4
Chromodomain-helicase-DNA-binding protein 4

2

6

High-throughput

0.571

High

473448

CHD5
Chromodomain-helicase-DNA-binding protein 5

2

6

High-throughput

0.571

High

473488

NS1BP
Influenza virus NS1A-binding protein

2

1

High-throughput

0.571

High

473452

ELMO1
Engulfment and cell motility protein 1

1

0

Small-scale

0.554

High

70089

CRTP1
Cysteine-rich tail protein 1

2

1

High-throughput

0.553

High

473397

CTG1B
Cancer/testis antigen 1

2

1

High-throughput

0.553

High

473446

PNMA1
Paraneoplastic antigen Ma1

2

4

High-throughput

0.553

High

473436

LTMD1
LETM1 domain-containing protein 1

2

0

High-throughput

0.551

High

473359

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

2

0

High-throughput

0.547

High

473379

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

2

0

High-throughput

0.547

High

473480

DPP2
Dipeptidyl peptidase 2

2

0

High-throughput

0.547

High

209870

ADA12
Disintegrin and metalloproteinase domain-containing protein 12

1

20

Small-scale

0.536

High

473353

ANDR
Androgen receptor

1

20

High-throughput

0.536

High

473373

SPR2A
Small proline-rich protein 2A

1

6

Small-scale

0.536

High

473470

TMG4
Transmembrane gamma-carboxyglutamic acid protein 4

1

6

Small-scale

0.536

High

473440

ADCK2
Uncharacterized aarF domain-containing protein kinase 2

1

1

High-throughput

0.536

High

219543

WIPF1
WAS/WASL-interacting protein family member 1

1

20

Small-scale

0.527

High

473381

TNFL6
Tumor necrosis factor ligand superfamily member 6

1

12

Small-scale

0.527

High

240042

KPRB
Phosphoribosyl pyrophosphate synthase-associated protein 2

2

11

High-throughput

0.521

High

350572

TXD12
Thioredoxin domain-containing protein 12

2

1

High-throughput

0.521

High

473418

KPRA
Phosphoribosyl pyrophosphate synthase-associated protein 1

2

11

High-throughput

0.521

High

473459

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

2

2

High-throughput

0.521

High

473350

WNT2
Protein Wnt-2

1

0

High-throughput

0.518

High

473463

RUFY1
RUN and FYVE domain-containing protein 1

1

15

Small-scale

0.515

High

473472

MED28
Mediator of RNA polymerase II transcription subunit 28

1

8

Small-scale

0.515

High

473416

FHL2
Four and a half LIM domains protein 2

1

20

High-throughput

0.508

High

473389

NAL12
NACHT, LRR and PYD domains-containing protein 12

1

1

Small-scale

0.506

High

421345

A4
Amyloid-beta precursor protein

1

11

High-throughput

0.501

High

473370

RL10
Large ribosomal subunit protein uL16

1

4

Small-scale

0.501

High

473412

U119A
Protein unc-119 homolog A

1

4

Small-scale

0.501

High

473455

CBP
CREB-binding protein

1

15

Small-scale

0.501

High

473471

ADA19
Disintegrin and metalloproteinase domain-containing protein 19

1

20

Small-scale

0.501

High

473479

ADA22
Disintegrin and metalloproteinase domain-containing protein 22

1

20

Small-scale

0.501

High

301306

WFS1
Wolframin

1

0

High-throughput

0.493

High

385380

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

9

High-throughput

0.481

High

160977

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

20

Small-scale

0.479

High

324433

HEXI1
Protein HEXIM1

1

6

High-throughput

0.479

High

473349

LEG1
Galectin-1

1

1

High-throughput

0.479

High

473360

FCGR1
High affinity immunoglobulin gamma Fc receptor I

1

19

Small-scale

0.479

High

473363

PECA1
Platelet endothelial cell adhesion molecule

1

17

Small-scale

0.479

High

473365

NUCL
Nucleolin

1

3

Small-scale

0.479

High

473382

PAXI
Paxillin

1

20

High-throughput

0.479

High

473386

CCR3
C-C chemokine receptor type 3

1

7

Small-scale

0.479

High

473387

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

5

High-throughput

0.479

High

473393

ACTB
Actin, cytoplasmic 1

1

5

Small-scale

0.479

High

473396

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

11

Small-scale

0.479

High

473400

UPAR
Urokinase plasminogen activator surface receptor

1

2

Small-scale

0.479

High

473421

KIF14
Kinesin-like protein KIF14

1

9

High-throughput

0.479

High

473425

SF3B3
Splicing factor 3B subunit 3

1

2

Small-scale

0.479

High

473428

LARP7
La-related protein 7

1

12

High-throughput

0.479

High

473474

TRPV4
Transient receptor potential cation channel subfamily V member 4

1

11

Small-scale

0.479

High

473475

GPVI
Platelet glycoprotein VI

1

14

Small-scale

0.479

High

473481

EVL
Ena/VASP-like protein

1

17

Small-scale

0.479

High

473352

NT2NC
Notch homolog 2 N-terminal-like protein C

1

9

High-throughput

0.470

High

473466

TS101
Tumor susceptibility gene 101 protein

1

0

Small-scale

0.458

High

473467

CNPY3
Protein canopy homolog 3

1

0

Small-scale

0.458

High

252407

DIAP1
Protein diaphanous homolog 1

1

11

Small-scale

0.445

High

473351

LOX5
Polyunsaturated fatty acid 5-lipoxygenase

1

6

Small-scale

0.445

High

473444

CD177
CD177 antigen

1

1

Small-scale

0.445

High

465

NBPFJ
NBPF family member NBPF19

1

8

High-throughput

0.439

High

473473

WDCP
WD repeat and coiled-coil-containing protein

1

1

Small-scale

0.437

High

473398

MDM2
E3 ubiquitin-protein ligase Mdm2

1

5

Small-scale

0.408

High

473449

NEUFC
Neuferricin

2

0

High-throughput

0.316

High

473460

CA074
UPF0739 protein C1orf74

1

0

High-throughput

0.279

Low

473484

RT02
Small ribosomal subunit protein uS2m

1

0

High-throughput

0.279

Low

473438

CHSTF
Carbohydrate sulfotransferase 15

1

0

Small-scale

0.249

Low

473437

Q75KN0
Uncharacterized protein FLJ10842

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025