HitPredict

Interactor 1: RU2B (P08579)
U2 small nuclear ribonucleoprotein B'' (U2 snRNP B'')
Gene: SNRPB2

Interactor 2: RBM22 (Q9NW64)
Pre-mRNA-splicing factor RBM22 (RNA-binding motif protein 22) (Zinc finger CCCH domain-containing protein 16)
Gene: RBM22

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	33961781, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0071007 - U2-type catalytic step 2 spliceosome GO:0071013 - catalytic step 2 spliceosome
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 225 Hs			1 420
+	Hs
		446810 SNRPA_HUMAN (2-225): 2.91e-42: 146: 48.56		RBM22_HUMAN (1-420): 6.25e-122: 362: 100.00
+	Hs
		1020338 ELAV2_HUMAN (128-224): 1.33e-15: 76.3: 19.61		RBM22_HUMAN (1-420): 6.25e-122: 362: 100.00
+	Hs
		446592 SNRPA_HUMAN (2-225): 2.91e-42: 146: 48.56		TIAR_HUMAN (107-361): 1.74e-30: 122: 12.64
+	Sc
		698623 NGR1_YEAST (3-224): 1.86e-42: 153: 18.29		NGR1_YEAST (214-315): 6.03e-18: 88: 30.39
+	Hs
		165379 RU2B_HUMAN (1-225): 5.14e-51: 166: 100.00		SR140_HUMAN (227-354): 8.9e-13: 72.2: 22.63
+	Sc
		376895 NAM8_YEAST (1-224): 5.12e-42: 150: 16.09		PABP_YEAST (221-316): 1.12e-13: 74.8: 20.59
+	Hs
		446516 SNRPA_HUMAN (2-225): 2.91e-42: 146: 48.56		TIA1_HUMAN (226-316): 1.84e-11: 67.1: 23.16
+	Mm
		665745 TIA1_MOUSE (2-160): 4.64e-17: 80.5: 14.29		PABP1_MOUSE (105-316): 1.53e-31: 128: 15.74
+	Hs
		516484 ELAV2_HUMAN (128-224): 1.33e-15: 76.3: 19.61		PABP1_HUMAN (105-316): 1.37e-31: 128: 15.74
+	Sp
		953367 RU2B_SCHPO (7-94): 7.83e-38: 129: 53.41		CWC2_SCHPO (139-318): 8.87e-14: 74.5: 22.28
+	Hs
		680439 TIA1_HUMAN (2-160): 1.14e-16: 79.4: 13.04		TIAR_HUMAN (107-361): 1.74e-30: 122: 12.64
+	Hs
		235683 HNRPQ_HUMAN (4-224): 8.43e-14: 71.6: 20.00		PABP1_HUMAN (105-316): 1.37e-31: 128: 15.74
+	Hs
		516495 PABP4_HUMAN (148-225): 1.72e-13: 70.9: 19.28		PABP1_HUMAN (105-316): 1.37e-31: 128: 15.74
+	Hs
		516339 PABP1_HUMAN (141-225): 2.1e-13: 70.5: 17.78		PABP1_HUMAN (105-316): 1.37e-31: 128: 15.74
+	Zm
		8143 A0A1D6ELH4_MAIZE (5-159): 2.68e-19: 87.9: 18.47		A0A1D6ELH4_MAIZE (230-313): 2.95e-11: 67.1: 20.00
+	Hs
		1020249 ELAV2_HUMAN (128-224): 1.33e-15: 76.3: 19.61		PABP4_HUMAN (223-313): 8.3e-15: 78.3: 21.65
+	Hs
		235835 HNRPQ_HUMAN (4-224): 8.43e-14: 71.6: 20.00		PABP4_HUMAN (223-313): 8.3e-15: 78.3: 21.65
+	Hs
		680422 TIA1_HUMAN (2-160): 1.14e-16: 79.4: 13.04		TIA1_HUMAN (226-316): 1.84e-11: 67.1: 23.16
+	Mm
		857343 HNRPQ_MOUSE (4-224): 1.17e-13: 71.3: 20.00		TIA1_MOUSE (226-316): 1.54e-11: 67.5: 23.16