HitPredict

Interactor 1: MET (P08581)
Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
Gene: MET

Interactor 2: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 0.60 0.762

The method score is based on:

Property Details
Experiments 15123609, 11894096, 17533376, 16397241, 21222362, 21163258, 18273061, 35309168, 19450681, 19433454
Identification Methods far western blotting, enzymatic study, affinity chromatography technology, pull down, x-ray crystallography, anti bait coimmunoprecipitation, coimmunoprecipitation, experimental interaction detection, isothermal titration calorimetry, surface plasmon resonance and 1 others

more...
Interaction Type direct interaction, physical association, association, ubiquitination reaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005886 - plasma membrane
GO:0007165 - signal transduction
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 1390
Hs

1 906
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Last updated: 15 Jul 2024