HitPredict

Interactor 1: MET (P08581)
Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
Gene: MET

Interactor 2: DSC3 (Q14574)
Desmocollin-3 (Cadherin family member 3) (Desmocollin-4) (HT-CP)
Gene: DSC3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1390 Hs			1 896
+	Mm
		555033 MET_MOUSE (1-1381): 0: 1246: 89.57		PCDAA_MOUSE (2-470): 1.52e-87: 301: 16.60
+	Hs
		441427 MET_HUMAN (1-1390): 0: 1283: 100.00		CADH2_HUMAN (2-385): 2.16e-54: 205: 17.55
+	Hs
		441414 MET_HUMAN (1-1390): 0: 1283: 100.00		CADH1_HUMAN (2-464): 1.66e-38: 157: 15.98
+	Hs
		872600 EPHB4_HUMAN (736-1342): 2.91e-128: 424: 21.72		PCDG6_HUMAN (1-818): 0: 732: 18.48
+	Hs
		580213 EPHA4_HUMAN (555-1389): 3.08e-175: 549: 17.20		CADH2_HUMAN (2-385): 2.16e-54: 205: 17.55
+	Hs
		872602 EPHB4_HUMAN (736-1342): 2.91e-128: 424: 21.72		PCDA8_HUMAN (2-470): 1.82e-86: 298: 16.16
+	Hs
		872601 EPHB4_HUMAN (736-1342): 2.91e-128: 424: 21.72		PCDG5_HUMAN (2-464): 1.03e-81: 284: 17.86
+	Hs
		580236 EPHA7_HUMAN (587-1389): 6.03e-156: 498: 18.53		CADH2_HUMAN (2-385): 2.16e-54: 205: 17.55
+	Hs
		872598 EPHB4_HUMAN (736-1342): 2.91e-128: 424: 21.72		PCDB3_HUMAN (2-475): 2.75e-78: 272: 15.99
+	Hs
		872427 EPHA5_HUMAN (579-1346): 3.64e-177: 556: 19.08		DSC2_HUMAN (3-350): 7.18e-27: 120: 13.83
+	Hs
		872632 EPHA4_HUMAN (555-1389): 3.08e-175: 549: 17.20		DSC2_HUMAN (3-350): 7.18e-27: 120: 13.83
+	Hs
		850513 PLXA3_HUMAN (381-1019): 8.58e-111: 388: 17.82		PCDBF_HUMAN (2-475): 4.23e-81: 280: 17.00
+	Hs
		850512 PLXA3_HUMAN (381-1019): 8.58e-111: 388: 17.82		PCDB3_HUMAN (2-475): 2.75e-78: 272: 15.99
+	Hs
		665396 EPHA3_HUMAN (584-1379): 1.09e-179: 561: 18.13		DSG2_HUMAN (69-391): 3.52e-20: 98.5: 17.85
+	Hs
		872440 EPHA5_HUMAN (579-1346): 3.64e-177: 556: 19.08		DSG2_HUMAN (69-391): 3.52e-20: 98.5: 17.85
+	Hs
		872645 EPHA4_HUMAN (555-1389): 3.08e-175: 549: 17.20		DSG2_HUMAN (69-391): 3.52e-20: 98.5: 17.85
+	Hs
		971014 EPHA7_HUMAN (587-1389): 6.03e-156: 498: 18.53		DSC2_HUMAN (3-350): 7.18e-27: 120: 13.83
+	Hs
		1048589 EPHA7_HUMAN (587-1389): 6.03e-156: 498: 18.53		DSG2_HUMAN (69-391): 3.52e-20: 98.5: 17.85
+	Hs
		601509 FGFR2_HUMAN (1029-1379): 3.01e-105: 355: 33.15		DSG2_HUMAN (69-391): 3.52e-20: 98.5: 17.85
+	Hs
		674419 UFO_HUMAN (1078-1333): 5.27e-66: 243: 45.90		DSG2_HUMAN (69-391): 3.52e-20: 98.5: 17.85