Protein: KLK15
Kallikrein-15 (EC 3.4.21.-) (ACO protease)

Gene: KLK15
Organism: Homo sapiens
Interactions: 161
UniProt ID: Q9H2R5

Gene Ontology (top 5):
GO:0004252 - serine-type endopeptidase activity
GO:0005615 - extracellular space
GO:0006508 - proteolysis
GO:0008236 - serine-type peptidase activity
GO:0030141 - secretory granule

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

211950

SPIT1
Kunitz-type protease inhibitor 1

1

15

High-throughput

0.691

High

562758

BMP1
Bone morphogenetic protein 1

1

11

High-throughput

0.691

High

1160930

PRSS8
Prostasin

1

13

High-throughput

0.691

High

1432132

LOXL2
Lysyl oxidase homolog 2

1

10

High-throughput

0.691

High

1432134

ST14
Suppressor of tumorigenicity 14 protein

1

17

High-throughput

0.691

High

193720

TPSN
Tapasin

1

5

High-throughput

0.618

High

274916

LRP5
Low-density lipoprotein receptor-related protein 5

1

11

High-throughput

0.618

High

287608

LRP6
Low-density lipoprotein receptor-related protein 6

1

12

High-throughput

0.618

High

376547

LDLR
Low-density lipoprotein receptor

1

13

High-throughput

0.618

High

1055361

APLP2
Amyloid beta precursor like protein 2

1

14

High-throughput

0.618

High

1336108

KREM2
Kremen protein 2

1

17

High-throughput

0.618

High

1432115

ANTR1
Anthrax toxin receptor 1

1

6

High-throughput

0.618

High

1432117

CELR2
Cadherin EGF LAG seven-pass G-type receptor 2

1

12

High-throughput

0.618

High

1432122

CELR1
Cadherin EGF LAG seven-pass G-type receptor 1

1

13

High-throughput

0.618

High

1432129

JAG2
Protein jagged-2

1

9

High-throughput

0.618

High

997131

TBA4A
Tubulin alpha-4A chain

2

18

High-throughput

0.574

High

227029

MCAT
Mitochondrial carnitine/acylcarnitine carrier protein

2

20

High-throughput

0.558

High

1411842

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

2

9

High-throughput

0.558

High

991933

DYLT1
Dynein light chain Tctex-type 1

2

1

High-throughput

0.553

High

756583

GALNS
N-acetylgalactosamine-6-sulfatase

2

9

High-throughput

0.549

High

464471

TSP1
Thrombospondin-1

1

17

High-throughput

0.536

High

467851

BGLR
Beta-glucuronidase

1

3

High-throughput

0.536

High

472207

TRFM
Melanotransferrin

1

3

High-throughput

0.536

High

709079

PCSK6
Proprotein convertase subtilisin/kexin type 6

1

16

High-throughput

0.536

High

760804

BMP8B
Bone morphogenetic protein 8B

1

7

High-throughput

0.536

High

1105779

ADAM9
Disintegrin and metalloproteinase domain-containing protein 9

1

14

High-throughput

0.536

High

1366363

GPI8
GPI-anchor transamidase

1

2

High-throughput

0.536

High

1416334

CHID1
Chitinase domain-containing protein 1

1

3

High-throughput

0.536

High

1432116

RISC
Retinoid-inducible serine carboxypeptidase

1

3

High-throughput

0.536

High

1432128

ADA21
Disintegrin and metalloproteinase domain-containing protein 21

1

13

High-throughput

0.536

High

1151647

TRIP6
Thyroid receptor-interacting protein 6

1

1

High-throughput

0.523

High

1194503

ERFE
Erythroferrone

1

0

High-throughput

0.513

High

62218

DEN11
DENN domain-containing protein 11

1

3

High-throughput

0.489

High

67385

RTL8C
Retrotransposon Gag-like protein 8C

1

1

High-throughput

0.489

High

161753

APAF
Apoptotic protease-activating factor 1

1

3

High-throughput

0.489

High

249664

SNX3
Sorting nexin-3

1

4

High-throughput

0.489

High

320049

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.489

High

321041

SUN1
SUN domain-containing protein 1

1

2

High-throughput

0.489

High

322762

RHBT3
Rho-related BTB domain-containing protein 3

1

8

High-throughput

0.489

High

324044

CSTN1
Calsyntenin-1

1

20

High-throughput

0.489

High

327119

NXPH4
Neurexophilin-4

1

1

High-throughput

0.489

High

335708

MOCS3
Adenylyltransferase and sulfurtransferase MOCS3

1

3

High-throughput

0.489

High

343643

OXSR1
Serine/threonine-protein kinase OSR1

1

7

High-throughput

0.489

High

354178

CLPT1
Putative lipid scramblase CLPTM1

1

1

High-throughput

0.489

High

359875

DYR
Dihydrofolate reductase

1

1

High-throughput

0.489

High

571251

PERF
Perforin-1

1

1

High-throughput

0.489

High

600630

NAGAB
Alpha-N-acetylgalactosaminidase

1

1

High-throughput

0.489

High

612118

ITB5
Integrin beta-5

1

7

High-throughput

0.489

High

618206

AMD
Peptidyl-glycine alpha-amidating monooxygenase

1

2

High-throughput

0.489

High

755513

ERD22
ER lumen protein-retaining receptor 2

1

2

High-throughput

0.489

High

858715

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

6

High-throughput

0.489

High

884849

PPM1F
Protein phosphatase 1F

1

3

High-throughput

0.489

High

885506

MA2A2
Alpha-mannosidase 2x

1

8

High-throughput

0.489

High

932389

ANAG
Alpha-N-acetylglucosaminidase

1

2

High-throughput

0.489

High

937438

LAMB2
Laminin subunit beta-2

1

7

High-throughput

0.489

High

1017813

CCZ1B
Vacuolar fusion protein CCZ1 homolog B

1

1

High-throughput

0.489

High

1037041

DSC2
Desmocollin-2

1

6

High-throughput

0.489

High

1049199

RON
Macrophage-stimulating protein receptor

1

13

High-throughput

0.489

High

1061872

TLE5
TLE family member 5

1

2

High-throughput

0.489

High

1089127

HYAL2
Hyaluronidase-2

1

2

High-throughput

0.489

High

1105240

S39A6
Zinc transporter ZIP6

1

7

High-throughput

0.489

High

1111698

STIM1
Stromal interaction molecule 1

1

2

High-throughput

0.489

High

1125059

RCN2
Reticulocalbin-2

1

4

High-throughput

0.489

High

1143675

NOMO1
BOS complex subunit NOMO1

1

2

High-throughput

0.489

High

1143790

PON2
Serum paraoxonase/arylesterase 2

1

4

High-throughput

0.489

High

1150082

MARE2
Microtubule-associated protein RP/EB family member 2

1

1

High-throughput

0.489

High

1164355

CGT
2-hydroxyacylsphingosine 1-beta-galactosyltransferase

1

3

High-throughput

0.489

High

1191976

TBB8
Tubulin beta-8 chain

1

18

High-throughput

0.489

High

1193214

OFUT4
GDP-fucose protein O-fucosyltransferase 4

1

2

High-throughput

0.489

High

1212694

GT253
Inactive glycosyltransferase 25 family member 3

1

7

High-throughput

0.489

High

1216526

BIG3
Brefeldin A-inhibited guanine nucleotide-exchange protein 3

1

4

High-throughput

0.489

High

1228368

GL8D1
Glycosyltransferase 8 domain-containing protein 1

1

2

High-throughput

0.489

High

1228403

SE1L3
Protein sel-1 homolog 3

1

3

High-throughput

0.489

High

1229203

INT3
Integrator complex subunit 3

1

1

High-throughput

0.489

High

1231143

SCAR3
Scavenger receptor class A member 3

1

7

High-throughput

0.489

High

1242092

TTC27
Tetratricopeptide repeat protein 27

1

6

High-throughput

0.489

High

1245617

TXD11
Thioredoxin domain-containing protein 11

1

11

High-throughput

0.489

High

1248341

PLGT2
Protein O-glucosyltransferase 2

1

4

High-throughput

0.489

High

1259496

TBA1A
Tubulin alpha-1A chain

1

20

High-throughput

0.489

High

1294003

ANKL2
Ankyrin repeat and LEM domain-containing protein 2

1

2

High-throughput

0.489

High

1294728

DAAF5
Dynein axonemal assembly factor 5

1

1

High-throughput

0.489

High

1309649

GLBL2
Beta-galactosidase-1-like protein 2

1

1

High-throughput

0.489

High

1310029

FXRD2
FAD-dependent oxidoreductase domain-containing protein 2

1

1

High-throughput

0.489

High

1322646

RPTOR
Regulatory-associated protein of mTOR

1

4

High-throughput

0.489

High

1324224

VWDE
von Willebrand factor D and EGF domain-containing protein

1

12

High-throughput

0.489

High

1324389

ABD12
Lysophosphatidylserine lipase ABHD12

1

2

High-throughput

0.489

High

1324756

S35F6
Solute carrier family 35 member F6

1

1

High-throughput

0.489

High

1333636

SUMF1
Formylglycine-generating enzyme

1

4

High-throughput

0.489

High

1334256

ATAD1
Outer mitochondrial transmembrane helix translocase

1

3

High-throughput

0.489

High

1334411

UXS1
UDP-glucuronic acid decarboxylase 1

1

3

High-throughput

0.489

High

1337229

MCU
Calcium uniporter protein, mitochondrial

1

2

High-throughput

0.489

High

1364111

TM9S4
Transmembrane 9 superfamily member 4

1

5

High-throughput

0.489

High

1364150

TM131
Transmembrane protein 131

1

4

High-throughput

0.489

High

1372146

EXT2
Exostosin-2

1

4

High-throughput

0.489

High

1380532

PIGT
GPI-anchor transamidase component PIGT

1

4

High-throughput

0.489

High

1383469

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

2

High-throughput

0.489

High

1390352

I17RA
Interleukin-17 receptor A

1

3

High-throughput

0.489

High

1392664

MYO19
Unconventional myosin-XIX

1

1

High-throughput

0.489

High

1398248

H6ST2
Heparan-sulfate 6-O-sulfotransferase 2

1

1

High-throughput

0.489

High

1398793

MBOA7
Membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7

1

2

High-throughput

0.489

High

1401318

PASK
PAS domain-containing serine/threonine-protein kinase

1

4

High-throughput

0.489

High

1402142

JMJD8
JmjC domain-containing protein 8

1

1

High-throughput

0.489

High

1406183

PMYT1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

1

5

High-throughput

0.489

High

1408229

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

5

High-throughput

0.489

High

1410588

TBA1C
Tubulin alpha-1C chain

1

20

High-throughput

0.489

High

1410967

CSTN3
Calsyntenin-3

1

20

High-throughput

0.489

High

1411641

ADPGK
ADP-dependent glucokinase

1

2

High-throughput

0.489

High

1415039

EDEM2
ER degradation-enhancing alpha-mannosidase-like protein 2

1

5

High-throughput

0.489

High

1420135

EDEM3
ER degradation-enhancing alpha-mannosidase-like protein 3

1

5

High-throughput

0.489

High

1429269

ADA19
Disintegrin and metalloproteinase domain-containing protein 19

1

12

High-throughput

0.489

High

1432108

SPNS1
Protein spinster homolog 1

1

1

High-throughput

0.489

High

1432109

SEM6B
Semaphorin-6B

1

9

High-throughput

0.489

High

1432111

TOR3A
Torsin-3A

1

9

High-throughput

0.489

High

1432112

TBB1
Tubulin beta-1 chain

1

20

High-throughput

0.489

High

1432114

SG196
Protein O-mannose kinase

1

1

High-throughput

0.489

High

1432118

CHSTC
Carbohydrate sulfotransferase 12

1

2

High-throughput

0.489

High

1432120

ABCF3
ATP-binding cassette sub-family F member 3

1

2

High-throughput

0.489

High

1432125

STK39
STE20/SPS1-related proline-alanine-rich protein kinase

1

6

High-throughput

0.489

High

1432126

SUN2
SUN domain-containing protein 2

1

2

High-throughput

0.489

High

1432127

PLXA1
Plexin-A1

1

10

High-throughput

0.489

High

1432130

MA2B2
Epididymis-specific alpha-mannosidase

1

8

High-throughput

0.489

High

1432131

TMED5
Transmembrane emp24 domain-containing protein 5

1

11

High-throughput

0.489

High

1432135

AGRG1
Adhesion G-protein coupled receptor G1

1

4

High-throughput

0.489

High

1432136

COX11
Cytochrome c oxidase assembly protein COX11, mitochondrial

1

1

High-throughput

0.489

High

1388858

HOOK2
Protein Hook homolog 2

1

3

High-throughput

0.464

High

1432124

DKK3
Dickkopf-related protein 3

1

1

High-throughput

0.445

High

950001

KR103
Keratin-associated protein 10-3

1

5

High-throughput

0.439

High

175203

SC16A
Protein transport protein Sec16A

1

3

High-throughput

0.437

High

771612

HXD13
Homeobox protein Hox-D13

1

1

High-throughput

0.437

High

441505

AGAL
Alpha-galactosidase A

1

1

High-throughput

0.407

High

553441

FCERA
High affinity immunoglobulin epsilon receptor subunit alpha

1

4

High-throughput

0.407

High

582362

ARSA
Arylsulfatase A

1

9

High-throughput

0.407

High

848440

MAGA6
Melanoma-associated antigen 6

1

4

High-throughput

0.407

High

848976

MAGAC
Melanoma-associated antigen 12

1

4

High-throughput

0.407

High

1165259

RTL8B
Retrotransposon Gag-like protein 8B

1

1

High-throughput

0.407

High

1244646

GASP3
G protein-coupled receptor associated sorting protein 3

1

2

High-throughput

0.407

High

1286300

GALT7
N-acetylgalactosaminyltransferase 7

1

9

High-throughput

0.407

High

1323804

ARG28
Rho guanine nucleotide exchange factor 28

1

3

High-throughput

0.407

High

1339460

TOIP2
Torsin-1A-interacting protein 2

1

1

High-throughput

0.407

High

1432113

ALG2
Alpha-1,3/1,6-mannosyltransferase ALG2

1

1

High-throughput

0.407

High

1363972

SMG7
Nonsense-mediated mRNA decay factor SMG7

3

0

High-throughput

0.347

High

1356277

ABHD3
Phospholipase ABHD3

2

0

High-throughput

0.318

High

158502

RFXK
DNA-binding protein RFXANK

1

0

High-throughput

0.279

Low

187559

FANCA
Fanconi anemia group A protein

1

0

High-throughput

0.279

Low

208081

TTI1
TELO2-interacting protein 1 homolog

1

0

High-throughput

0.279

Low

720433

ACHA5
Neuronal acetylcholine receptor subunit alpha-5

1

0

High-throughput

0.279

Low

941970

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.279

Low

1006031

ASIC1
Acid-sensing ion channel 1

1

0

High-throughput

0.279

Low

1034818

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

0

High-throughput

0.279

Low

1125655

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

0

High-throughput

0.279

Low

1175842

T132A
Transmembrane protein 132A

1

0

High-throughput

0.279

Low

1245224

BRAT1
Integrator complex assembly factor BRAT1

1

0

High-throughput

0.279

Low

1309165

MISP
Mitotic interactor and substrate of PLK1

1

0

High-throughput

0.279

Low

1382885

TTC17
Tetratricopeptide repeat protein 17

1

0

High-throughput

0.279

Low

1387063

COQ8B
Atypical kinase COQ8B, mitochondrial

1

0

High-throughput

0.279

Low

1430685

F234A
Protein FAM234A

1

0

High-throughput

0.279

Low

1432119

OSTC
Oligosaccharyltransferase complex subunit OSTC

1

0

High-throughput

0.279

Low

1432121

CLN6
Ceroid-lipofuscinosis neuronal protein 6

1

0

High-throughput

0.279

Low

1432123

SELN
Selenoprotein N

1

0

High-throughput

0.279

Low

1432133

ENTP2
Ectonucleoside triphosphate diphosphohydrolase 2

1

0

High-throughput

0.279

Low

1432110

IFG15
Torsin-1A-interacting protein 2, isoform IFRG15

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025