HitPredict

Interactor 1: ADRB1 (P08588)
Beta-1 adrenergic receptor (Beta-1 adrenoreceptor) (Beta-1 adrenoceptor)
Gene: ADRB1

Interactor 2: ARRB1 (P49407)
Beta-arrestin-1 (Arrestin beta-1) (Non-visual arrestin-2)
Gene: ARRB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.799

Property	Details
Experiments	10862778, 18787115
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	7tm_1~Arrestin_C, 7tm_1~Arrestin_N
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 477 Hs			1 418
+	Hs
		441648 ADRB1_HUMAN (1-477): 6.12e-120: 361: 100.00		ARRB2_HUMAN (1-407): 0: 626: 76.15
+	Hs
		428933 ADRB2_HUMAN (38-472): 6.34e-95: 294: 46.67		ARRB2_HUMAN (1-407): 0: 626: 76.15
+	Rn
		663954 Q8VBU7_RAT (38-472): 3.98e-96: 298: 46.90		ARRB2_RAT (1-407): 0: 616: 75.00
+	Hs
		656989 5HT2A_HUMAN (22-401): 9.66e-73: 239: 27.18		ARRB2_HUMAN (1-407): 0: 626: 76.15