HitPredict

Interactor 1: RU17 (P08621)
U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70)
Gene: SNRNP70

Interactor 2: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.629

Property	Details
Experiments	29802200, unassigned1973, 35063084
Identification Methods	affinity chromatography technology, two hybrid fragment pooling approach, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0016607 - nuclear speck
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 437 Hs			1 758
+	Hs
		496179 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Rn
		582032 PABP1_RAT (4-361): 4.42e-53: 189: 11.08		TAU_RAT (1-758): 4.86e-75: 260: 71.47
+	Rn
		94258 PABP1_RAT (4-361): 4.42e-53: 189: 11.08		F1LST4_RAT (1-757): 8.59e-75: 260: 71.56
+	Mm
		498054 Q62029_MOUSE (4-380): 1.01e-52: 188: 10.32		TAU_MOUSE (1-758): 1.4e-69: 244: 70.17
+	Hs
		496957 PABP4_HUMAN (2-265): 2.72e-31: 128: 11.81		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496405 TIA1_HUMAN (98-338): 2.21e-18: 88.4: 12.95		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		235680 HNRPQ_HUMAN (4-313): 1.11e-16: 84.2: 13.55		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Mm
		497953 TIA1_MOUSE (3-246): 4.89e-27: 113: 13.42		TAU_MOUSE (1-758): 1.4e-69: 244: 70.17
+	Mm
		498066 HNRPQ_MOUSE (4-313): 2.53e-16: 83.4: 13.55		TAU_MOUSE (1-758): 1.4e-69: 244: 70.17
+	Dm
		54311 SET1_DROME (53-387): 1.25e-41: 160: 20.59		A1Z9J3_DROME (14-746): 5.58e-33: 139: 11.47
+	Hs
		516595 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		KMT2C_HUMAN (83-649): 6.28e-09: 61.8: 12.91
+	Dm
		1129083 SET1_DROME (53-387): 1.25e-41: 160: 20.59		Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96
+	Ce
		107192 SIG7_CAEEL (30-257): 1.69e-32: 129: 24.12		RPB1_CAEEL (82-426): 9.08e-11: 68: 14.12