HitPredict

Interactor 1: RU17 (P08621)
U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70)
Gene: SNRNP70

Interactor 2: RUXF (P62306)
Small nuclear ribonucleoprotein F (snRNP-F) (Sm protein F) (Sm-F) (SmF)
Gene: SNRPF

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.948

Property	Details
Experiments	29802200, 24981860, 33961781, 28514442, 35271311, 26828962
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	LSM~U1snRNP70_N
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005681 - spliceosomal complex and 1 others more... GO:0005685 - U1 snRNP
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 437 Hs			1 86
+	Dm
		565307 RU17_DROME (1-212): 1.83e-50: 178: 68.40		RUXF_DROME (3-86): 4.78e-34: 113: 78.57
+	Hs
		442631 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		LSM4_HUMAN (7-80): 5.94e-33: 112: 32.00
+	Hs
		911852 U1SBP_HUMAN (83-301): 7.9e-48: 166: 40.46		RUXF_HUMAN (1-75): 6.7e-33: 110: 100.00
+	Sp
		143344 RU17_SCHPO (1-277): 2.14e-51: 175: 38.27		RUXF_SCHPO (3-74): 9.06e-29: 99: 66.67
+	Sp
		143359 RU17_SCHPO (1-277): 2.14e-51: 175: 38.27		SMD3_SCHPO (8-76): 1.62e-23: 87.3: 23.19
+	Sc
		795407 RU17_YEAST (3-297): 9.1e-46: 162: 26.58		SMD3_YEAST (1-76): 1.44e-26: 95: 25.00
+	Dm
		218355 RU17_DROME (1-212): 1.83e-50: 178: 68.40		SMD3_DROME (5-76): 1.75e-19: 78.4: 19.44
+	Sc
		873653 RU17_YEAST (3-297): 9.1e-46: 162: 26.58		RUXF_YEAST (4-77): 6.37e-26: 93: 56.00
+	Hs
		442613 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		LSM2_HUMAN (9-86): 6.59e-24: 88: 28.40
+	Hs
		912648 U1SBP_HUMAN (83-301): 7.9e-48: 166: 40.46		SMD3_HUMAN (5-76): 4.51e-21: 81.9: 22.22
+	Hs
		442016 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		SMD3_HUMAN (5-76): 4.51e-21: 81.9: 22.22
+	Sc
		376892 PABP_YEAST (2-281): 3.47e-29: 121: 12.15		RUXF_YEAST (4-77): 6.37e-26: 93: 56.00
+	Sc
		376759 PABP_YEAST (2-281): 3.47e-29: 121: 12.15		LSM2_YEAST (9-86): 4.37e-21: 81.1: 29.63
+	Sc
		376804 PABP_YEAST (2-281): 3.47e-29: 121: 12.15		LSM4_YEAST (7-85): 1.93e-19: 79.2: 23.33
+	Hs
		235785 HNRPQ_HUMAN (4-313): 1.11e-16: 84.2: 13.55		RUXF_HUMAN (1-75): 6.7e-33: 110: 100.00
+	Sc
		376893 PABP_YEAST (2-281): 3.47e-29: 121: 12.15		LSM3_YEAST (5-82): 2.63e-09: 50.7: 23.53