HitPredict

Interactor 1: RU17 (P08621)
U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70)
Gene: SNRNP70

Interactor 2: RMXL1 (Q96E39)
RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1)
Gene: RBMXL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	28514442, 29802200, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1, RRM_1~U1snRNP70_N
Common GO terms	GO:0003723 - RNA binding GO:0005681 - spliceosomal complex GO:0048026 - positive regulation of mRNA splicing, via spliceosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 437 Hs			1 390
+	Hs
		516389 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		RBMX_HUMAN (1-390): 4.19e-44: 158: 92.07
+	Hs
		441917 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		RBMX_HUMAN (1-390): 4.19e-44: 158: 92.07
+	Hs
		516744 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		PPIE_HUMAN (10-96): 1.17e-30: 120: 39.08
+	Hs
		442177 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		SAFB1_HUMAN (7-390): 4.69e-33: 133: 14.25
+	Hs
		1288613 PABP5_HUMAN (4-350): 4.45e-37: 141: 11.14		RMXL1_HUMAN (1-357): 3.75e-42: 153: 100.00
+	Hs
		516484 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		ELAV2_HUMAN (2-133): 2.03e-23: 101: 24.09
+	Hs
		442150 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		CIRBP_HUMAN (4-145): 3.72e-32: 120: 45.70
+	Hs
		516495 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		PABP4_HUMAN (8-97): 3.48e-19: 91.5: 28.89
+	Mm
		665745 PABP1_MOUSE (4-361): 4.42e-53: 189: 11.08		TIA1_MOUSE (2-344): 1.69e-18: 88: 14.59
+	Hs
		516518 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		RBM39_HUMAN (3-112): 6.61e-15: 77.9: 22.73
+	Hs
		1288654 PABP5_HUMAN (4-350): 4.45e-37: 141: 11.14		RBM7_HUMAN (2-268): 6.54e-33: 126: 22.68
+	Hs
		442112 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		ELAV2_HUMAN (2-133): 2.03e-23: 101: 24.09
+	Mm
		857334 RU17_MOUSE (1-437): 1.33e-49: 176: 89.78		TIA1_MOUSE (2-344): 1.69e-18: 88: 14.59
+	Hs
		442125 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		PABP4_HUMAN (8-97): 3.48e-19: 91.5: 28.89
+	Sc
		376897 RU17_YEAST (3-297): 9.1e-46: 162: 26.58		PABP_YEAST (5-96): 4.2e-19: 91.1: 19.57
+	Hs
		441896 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		TIA1_HUMAN (2-353): 1.72e-18: 88: 14.25
+	Hs
		442159 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		RBM39_HUMAN (3-112): 6.61e-15: 77.9: 22.73
+	Hs
		1020306 PABP5_HUMAN (4-350): 4.45e-37: 141: 11.14		ELAV2_HUMAN (2-133): 2.03e-23: 101: 24.09
+	Hs
		442070 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		RBM3_HUMAN (8-88): 1.05e-15: 75.9: 55.56
+	Hs
		1119141 PABP5_HUMAN (4-350): 4.45e-37: 141: 11.14		PAP1L_HUMAN (8-95): 4.06e-20: 94.1: 30.68