HitPredict

Interactor 1: RU17 (P08621)
U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70)
Gene: SNRNP70

Interactor 2: PUF60 (Q9UHX1)
Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) (FUSE-binding protein-interacting repressor) (FBP-interacting repressor) (Ro-binding protein 1) (RoBP1) (Siah-binding protein 1) (Siah-BP1)
Gene: PUF60

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	29802200
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1, RRM_1~U1snRNP70_N
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0071011 - precatalytic spliceosome
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 437 Hs			1 559
+	Hs
		516730 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		PUF60_HUMAN (1-559): 2.1e-103: 324: 100.00
+	Dm
		565309 RU17_DROME (1-212): 1.83e-50: 178: 68.40		PUF68_DROME (57-559): 1.81e-97: 311: 47.24
+	Hs
		516518 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		RBM39_HUMAN (113-555): 5.61e-70: 235: 19.78
+	Hs
		442159 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		RBM39_HUMAN (113-555): 5.61e-70: 235: 19.78
+	Hs
		516484 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		ELAV2_HUMAN (223-553): 1.56e-45: 165: 14.80
+	Hs
		516635 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		PABP5_HUMAN (133-308): 3.43e-45: 165: 23.86
+	Hs
		442112 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		ELAV2_HUMAN (223-553): 1.56e-45: 165: 14.80
+	Hs
		1020306 PABP5_HUMAN (4-350): 4.45e-37: 141: 11.14		ELAV2_HUMAN (223-553): 1.56e-45: 165: 14.80
+	Hs
		516621 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		CELF1_HUMAN (98-214): 1.29e-17: 87.5: 26.50
+	Hs
		516689 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		PABP3_HUMAN (479-559): 6.17e-13: 73.4: 19.75
+	Hs
		516495 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		PABP4_HUMAN (457-550): 1.89e-10: 65.7: 10.64
+	Hs
		516339 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		PABP1_HUMAN (457-550): 3.84e-10: 64.5: 10.64
+	Hs
		442362 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		CELF1_HUMAN (98-214): 1.29e-17: 87.5: 26.50
+	Sc
		376897 RU17_YEAST (3-297): 9.1e-46: 162: 26.58		PABP_YEAST (465-553): 7.06e-12: 69.9: 16.85
+	Hs
		442125 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		PABP4_HUMAN (457-550): 1.89e-10: 65.7: 10.64
+	Hs
		441852 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		PABP1_HUMAN (457-550): 3.84e-10: 64.5: 10.64
+	Dm
		1129084 SET1_DROME (53-387): 1.25e-41: 160: 20.59		Q9VM49_DROME (130-203): 2.05e-11: 68.6: 43.24
+	Hs
		474034 PABP5_HUMAN (4-350): 4.45e-37: 141: 11.14		PAB4L_HUMAN (479-559): 3.69e-14: 76.1: 20.99