HitPredict

Interactor 1: HCK (P08631)
Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck)
Gene: HCK

Interactor 2: ANDR (P10275)
Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4)
Gene: AR

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005102 - signaling receptor binding GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0008284 - positive regulation of cell population proliferation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 526 Hs			1 920
+	Hs
		487088 SRC_HUMAN (1-524): 0: 582: 54.51		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		411564 LCK_HUMAN (23-526): 0: 581: 64.89		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		433225 YES_HUMAN (1-524): 0: 570: 56.77		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		433537 LYN_HUMAN (22-526): 0: 554: 70.70		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		454790 FGR_HUMAN (22-524): 0: 552: 55.62		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		487245 BLK_HUMAN (22-526): 0: 540: 63.12		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		487203 ABL2_HUMAN (17-523): 5.55e-166: 503: 38.06		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		337320 ABL1_HUMAN (47-523): 1.77e-166: 502: 39.38		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		368894 SRC_HUMAN (1-524): 0: 582: 54.51		ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20
+	Hs
		368834 YES_HUMAN (1-524): 0: 570: 56.77		ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20
+	Mm
		403414 SRC_MOUSE (1-524): 0: 585: 55.56		ESR1_MOUSE (378-904): 2.5e-129: 403: 21.30
+	Rn
		411266 SRC_RAT (1-524): 0: 581: 55.45		ESR1_RAT (378-904): 2.19e-130: 406: 20.94
+	Hs
		377057 SRC_HUMAN (1-524): 0: 582: 54.51		GCR_HUMAN (444-920): 1.2e-117: 378: 40.85
+	Hs
		377006 LCK_HUMAN (23-526): 0: 581: 64.89		GCR_HUMAN (444-920): 1.2e-117: 378: 40.85
+	Hs
		522762 SRC_HUMAN (1-524): 0: 582: 54.51		RXRA_HUMAN (392-902): 7.05e-120: 374: 19.84
+	Hs
		523091 SRC_HUMAN (1-524): 0: 582: 54.51		ESR2_HUMAN (435-912): 2.48e-116: 367: 21.51
+	Hs
		377007 FYN_HUMAN (22-524): 0: 564: 57.79		GCR_HUMAN (444-920): 1.2e-117: 378: 40.85
+	Hs
		433435 YES_HUMAN (1-524): 0: 570: 56.77		ESR2_HUMAN (435-912): 2.48e-116: 367: 21.51
+	Hs
		414427 SRC_HUMAN (1-524): 0: 582: 54.51		PRGR_HUMAN (469-920): 4.71e-106: 352: 45.73
+	Hs
		487890 SRC_HUMAN (1-524): 0: 582: 54.51		RARA_HUMAN (460-902): 8.57e-110: 348: 19.87