Protein: RBL1
Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1)

Gene: RBL1
Organism: Homo sapiens
Interactions: 120
UniProt ID: P28749

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0005654 - nucleoplasm
GO:0005667 - transcription regulator complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

704971

E2F4
Transcription factor E2F4

11

20

Small-scale

0.970

High

704943

E2F1
Transcription factor E2F1

9

20

Small-scale

0.967

High

704963

TFDP2
Transcription factor Dp-2

2

11

Small-scale

0.802

High

667551

CDK2
Cyclin-dependent kinase 2

14

9

Small-scale

0.763

High

143398

E2F3
Transcription factor E2F3

2

20

Small-scale

0.754

High

704949

RBL2
Retinoblastoma-like protein 2

2

2

Small-scale

0.754

High

629064

CCNA2
Cyclin-A2

8

7

Small-scale

0.748

High

704974

LIN9
Protein lin-9 homolog

5

5

Small-scale

0.709

High

704955

CTBP1
C-terminal-binding protein 1

3

2

High-throughput

0.667

High

704962

TFDP1
Transcription factor Dp-1

1

11

Small-scale

0.665

High

519465

MYBB
Myb-related protein B

3

4

Small-scale

0.664

High

704961

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

2

14

High-throughput

0.658

High

705000

DYR1B
Dual specificity tyrosine-phosphorylation-regulated kinase 1B

2

14

High-throughput

0.658

High

704979

CC062
Uncharacterized protein C3orf62

3

1

High-throughput

0.650

High

704984

LIN37
Protein lin-37 homolog

3

3

Small-scale

0.650

High

704957

HDAC1
Histone deacetylase 1

2

12

Small-scale

0.641

High

704918

PHB1
Prohibitin 1

2

2

Small-scale

0.624

High

704969

E2F5
Transcription factor E2F5

1

20

Small-scale

0.621

High

704964

E2F2
Transcription factor E2F2

1

20

Small-scale

0.618

High

704987

CTIP
DNA endonuclease RBBP8

2

3

Small-scale

0.613

High

704978

TXD11
Thioredoxin domain-containing protein 11

3

2

High-throughput

0.609

High

704950

RBBP4
Histone-binding protein RBBP4

2

9

High-throughput

0.601

High

704966

IRF3
Interferon regulatory factor 3

1

2

High-throughput

0.586

High

704938

SMAD3
Mothers against decapentaplegic homolog 3

1

1

Small-scale

0.561

High

704953

TP53B
TP53-binding protein 1

1

1

Small-scale

0.561

High

704982

TF3B
Transcription factor IIIB 90 kDa subunit

1

3

Small-scale

0.561

High

704986

NEB2
Neurabin-2

1

2

Small-scale

0.561

High

219695

FOXO3
Forkhead box protein O3

1

9

High-throughput

0.554

High

549061

CDK4
Cyclin-dependent kinase 4

1

19

Small-scale

0.550

High

704942

CDK6
Cyclin-dependent kinase 6

1

20

Small-scale

0.550

High

704973

LIN52
Protein lin-52 homolog

1

3

Small-scale

0.550

High

625205

CSK22
Casein kinase II subunit alpha'

1

16

High-throughput

0.536

High

704930

DCAF7
DDB1- and CUL4-associated factor 7

1

12

High-throughput

0.536

High

704934

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

5

Small-scale

0.536

High

704935

CSK21
Casein kinase II subunit alpha

1

12

High-throughput

0.536

High

704939

FOXK1
Forkhead box protein K1

1

9

High-throughput

0.536

High

704988

CITE1
Cbp/p300-interacting transactivator 1

1

2

High-throughput

0.536

High

704972

MK06
Mitogen-activated protein kinase 6

1

9

High-throughput

0.508

High

289213

CREG1
Protein CREG1

1

1

Small-scale

0.501

High

704916

KDM5A
Lysine-specific demethylase 5A

1

4

Small-scale

0.501

High

704917

MCM7
DNA replication licensing factor MCM7

1

2

Small-scale

0.501

High

704920

BRCA1
Breast cancer type 1 susceptibility protein

1

3

Small-scale

0.501

High

704936

CCNA1
Cyclin-A1

1

7

Small-scale

0.501

High

704958

SNW1
SNW domain-containing protein 1

1

2

Small-scale

0.501

High

704928

NEK4
Serine/threonine-protein kinase Nek4

1

1

High-throughput

0.489

High

704940

CYC
Cytochrome c

1

1

High-throughput

0.489

High

704959

DGKZ
Diacylglycerol kinase zeta

1

5

Small-scale

0.488

High

652449

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

3

High-throughput

0.481

High

704926

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

5

Small-scale

0.481

High

175843

SET1A
Histone-lysine N-methyltransferase SETD1A

1

9

Small-scale

0.479

High

188185

HDAC3
Histone deacetylase 3

1

12

Small-scale

0.479

High

216381

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

3

Small-scale

0.479

High

285096

EED
Polycomb protein EED

1

3

High-throughput

0.479

High

296397

RBBP9
Serine hydrolase RBBP9

1

4

Small-scale

0.479

High

371242

MYC
Myc proto-oncogene protein

1

2

Small-scale

0.479

High

464829

SP1
Transcription factor Sp1

1

2

Small-scale

0.479

High

519771

ANDR
Androgen receptor

1

3

Small-scale

0.479

High

587981

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

639671

TAF1
Transcription initiation factor TFIID subunit 1

1

6

Small-scale

0.479

High

666944

CCNE1
G1/S-specific cyclin-E1

1

12

Small-scale

0.479

High

694691

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

704914

EPHB2
Ephrin type-B receptor 2

1

3

High-throughput

0.479

High

704915

ARI4A
AT-rich interactive domain-containing protein 4A

1

6

Small-scale

0.479

High

704922

MAGAB
Melanoma-associated antigen 11

1

1

Small-scale

0.479

High

704923

CDN1C
Cyclin-dependent kinase inhibitor 1C

1

3

Small-scale

0.479

High

704925

CDK9
Cyclin-dependent kinase 9

1

17

High-throughput

0.479

High

704927

HCFC1
Host cell factor 1

1

1

Small-scale

0.479

High

704944

ID2
DNA-binding protein inhibitor ID-2

1

3

Small-scale

0.479

High

704951

EP300
Histone acetyltransferase p300

1

2

High-throughput

0.479

High

704956

SMAD4
Mothers against decapentaplegic homolog 4

1

1

Small-scale

0.479

High

704960

CUL4A
Cullin-4A

1

3

High-throughput

0.479

High

704967

SUZ12
Polycomb protein SUZ12

1

2

Small-scale

0.479

High

704976

LIN54
Protein lin-54 homolog

1

5

Small-scale

0.479

High

704981

HDAC2
Histone deacetylase 2

1

12

Small-scale

0.479

High

704983

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

2

High-throughput

0.479

High

704991

NEK6
Serine/threonine-protein kinase Nek6

1

1

High-throughput

0.479

High

704993

NLE1
Notchless protein homolog 1

1

1

High-throughput

0.479

High

704994

AATF
Protein AATF

1

2

Small-scale

0.479

High

704998

PHF8
Histone lysine demethylase PHF8

1

1

Small-scale

0.479

High

705001

LMBL1
Lethal(3)malignant brain tumor-like protein 1

1

2

Small-scale

0.479

High

705004

MOFA1
MORF4 family-associated protein 1

1

2

High-throughput

0.479

High

180484

PLS1
Phospholipid scramblase 1

1

0

High-throughput

0.460

High

704931

SMD3
Small nuclear ribonucleoprotein Sm D3

1

0

High-throughput

0.460

High

335784

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

1

0

High-throughput

0.458

High

704919

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

704924

EMD
Emerin

1

0

Small-scale

0.458

High

704932

1433Z
14-3-3 protein zeta/delta

1

0

High-throughput

0.458

High

704937

NTH
Endonuclease III-like protein 1

1

0

High-throughput

0.458

High

705002

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.458

High

704954

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

2

Small-scale

0.457

High

704977

RINT1
RAD50-interacting protein 1

1

2

Small-scale

0.457

High

413249

P53
Cellular tumor antigen p53

1

3

High-throughput

0.445

High

704952

CDC20
Cell division cycle protein 20 homolog

1

3

High-throughput

0.445

High

273256

T22D2
TSC22 domain family protein 2

1

7

Small-scale

0.439

High

704913

EPHA2
Ephrin type-A receptor 2

1

3

High-throughput

0.439

High

704929

LAMB2
Laminin subunit beta-2

1

1

High-throughput

0.439

High

411414

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.437

High

704965

BECN1
Beclin-1

1

2

Small-scale

0.437

High

704968

CDK10
Cyclin-dependent kinase 10

1

11

High-throughput

0.437

High

704980

SNX19
Sorting nexin-19

1

2

Small-scale

0.437

High

704999

PA2G4
Proliferation-associated protein 2G4

1

2

Small-scale

0.437

High

705003

MARF1
Meiosis regulator and mRNA stability factor 1

1

1

High-throughput

0.437

High

541845

TOP1
DNA topoisomerase 1

1

1

Small-scale

0.408

High

704941

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

1

High-throughput

0.407

High

704975

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

1

1

High-throughput

0.407

High

704989

BEGIN
Brain-enriched guanylate kinase-associated protein

1

0

High-throughput

0.304

High

389065

FINC
Fibronectin

1

0

High-throughput

0.251

Low

704945

NUCB1
Nucleobindin-1

1

0

High-throughput

0.251

Low

704947

AOXA
Aldehyde oxidase

1

0

High-throughput

0.251

Low

704948

GOGA2
Golgin subfamily A member 2

1

0

High-throughput

0.251

Low

704921

TSN7
Tetraspanin-7

1

0

High-throughput

0.249

Low

704933

DYL1
Dynein light chain 1, cytoplasmic

1

0

High-throughput

0.249

Low

704946

P2R3A
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha

1

0

Small-scale

0.249

Low

704970

TRIP6
Thyroid receptor-interacting protein 6

1

0

High-throughput

0.249

Low

704990

IFG15
Torsin-1A-interacting protein 2, isoform IFRG15

1

0

High-throughput

0.249

Low

704992

CD320
CD320 antigen

1

0

High-throughput

0.249

Low

704995

ARP3B
Actin-related protein 3B

1

0

High-throughput

0.249

Low

704996

XPO7
Exportin-7

1

0

High-throughput

0.249

Low

704997

DNPEP
Aspartyl aminopeptidase

1

0

High-throughput

0.249

Low

704985

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025