HitPredict

Interactor 1: HCK (P08631)
Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck)
Gene: HCK

Interactor 2: GPVI (Q9HCN6)
Platelet glycoprotein VI (GPVI) (Glycoprotein 6)
Gene: GP6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	19940238
Identification Methods	phage display
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 526 Hs			1 339
+	Hs
		433481 YES_HUMAN (1-524): 0: 570: 56.77		GPVI_HUMAN (1-339): 2.78e-74: 234: 100.00
+	Hs
		412364 FYN_HUMAN (22-524): 0: 564: 57.79		GPVI_HUMAN (1-339): 2.78e-74: 234: 100.00
+	Hs
		434021 LYN_HUMAN (22-526): 0: 554: 70.70		GPVI_HUMAN (1-339): 2.78e-74: 234: 100.00
+	Mm
		56907 FYN_MOUSE (22-524): 0: 564: 57.60		PTPRF_MOUSE (1-332): 1.64e-52: 188: 14.67
+	Hs
		411565 LCK_HUMAN (23-526): 0: 581: 64.89		PTPRF_HUMAN (112-324): 5.4e-27: 114: 14.41
+	Hs
		986398 BTK_HUMAN (19-519): 1.38e-155: 460: 33.52		GPVI_HUMAN (1-339): 2.78e-74: 234: 100.00
+	Hs
		411959 FYN_HUMAN (22-524): 0: 564: 57.79		PTPRF_HUMAN (112-324): 5.4e-27: 114: 14.41
+	Mm
		435881 HCK_MOUSE (1-526): 0: 609: 89.54		LIRB3_MOUSE (20-128): 9.17e-09: 58.9: 24.39
+	Hs
		433581 LYN_HUMAN (22-526): 0: 554: 70.70		FCAR_HUMAN (109-306): 2.82e-26: 107: 17.39
+	Hs
		434111 LYN_HUMAN (22-526): 0: 554: 70.70		ROBO1_HUMAN (108-336): 7.89e-25: 107: 12.81
+	Mm
		639452 LYN_MOUSE (22-526): 0: 555: 70.70		FCRL5_MOUSE (25-260): 8.91e-13: 70.8: 18.73
+	Hs
		434019 LYN_HUMAN (22-526): 0: 554: 70.70		ROBO2_HUMAN (7-249): 1.05e-12: 71.3: 14.44
+	Mm
		639442 LYN_MOUSE (22-526): 0: 555: 70.70		LIRB3_MOUSE (20-128): 9.17e-09: 58.9: 24.39
+	Dm
		219802 ABL_DROME (5-519): 3.97e-167: 515: 38.10		O44924_DROME (202-327): 1.04e-13: 74.3: 12.31