HitPredict

Interactor 1: ELK1 (P41969)
ETS domain-containing protein Elk-1
Gene: ELK1

Interactor 2: MK01 (P63085)
Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
Gene: Mapk1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.655

Property	Details
Experiments	9687507, 11435472, 15767678
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003690 - double-stranded DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 429 Mm			1 358
+	Mm
		785338 ELK1_MOUSE (1-429): 1.82e-62: 209: 100.00		MK03_MOUSE (13-355): 3.86e-153: 437: 88.34
+	Hs
		584208 ELK1_HUMAN (1-429): 6.02e-56: 192: 84.65		MK01_HUMAN (9-358): 5.56e-158: 448: 99.71
+	Hs
		584206 ELK1_HUMAN (1-429): 6.02e-56: 192: 84.65		MK03_HUMAN (3-356): 7.99e-154: 439: 85.88
+	Hs
		658856 ERF_HUMAN (5-253): 1.16e-49: 178: 27.38		MK01_HUMAN (9-358): 5.56e-158: 448: 99.71
+	Hs
		647519 ERF_HUMAN (5-253): 1.16e-49: 178: 27.38		MK03_HUMAN (3-356): 7.99e-154: 439: 85.88
+	Rn
		88640 D3ZJW0_RAT (5-253): 2e-49: 177: 27.38		MK03_RAT (13-355): 4.12e-153: 437: 88.34
+	Hs
		541984 ETS1_HUMAN (5-99): 2.32e-37: 143: 55.79		MK01_HUMAN (9-358): 5.56e-158: 448: 99.71
+	Rn
		78170 B5DEX5_RAT (5-96): 1.81e-42: 148: 50.00		MK03_RAT (13-355): 4.12e-153: 437: 88.34
+	Hs
		657805 ELK4_HUMAN (1-428): 1.38e-31: 126: 34.96		MK01_HUMAN (9-358): 5.56e-158: 448: 99.71
+	Hs
		658826 ETV3_HUMAN (5-406): 1.14e-30: 125: 20.05		MK01_HUMAN (9-358): 5.56e-158: 448: 99.71
+	Dm
		772961 POK_DROME (7-336): 4.95e-35: 139: 23.58		ERKA_DROME (5-355): 1.08e-150: 431: 80.63
+	Hs
		647473 ELK4_HUMAN (1-428): 1.38e-31: 126: 34.96		MK03_HUMAN (3-356): 7.99e-154: 439: 85.88
+	Hs
		542010 ETS1_HUMAN (5-99): 2.32e-37: 143: 55.79		MK07_HUMAN (9-356): 3.39e-140: 419: 49.15
+	Dm
		772960 PNT_DROME (5-99): 3.86e-32: 131: 55.79		ERKA_DROME (5-355): 1.08e-150: 431: 80.63
+	Ce
		106124 G5EDL0_CAEEL (1-411): 2.41e-35: 137: 23.60		MPK1_CAEEL (10-355): 1.12e-143: 415: 79.77
+	Hs
		647520 ETV1_HUMAN (4-90): 6.36e-23: 102: 60.92		MK03_HUMAN (3-356): 7.99e-154: 439: 85.88
+	Hs
		840374 ERF_HUMAN (5-253): 1.16e-49: 178: 27.38		MK14_HUMAN (16-354): 1.6e-111: 330: 48.97
+	Hs
		542017 ETS1_HUMAN (5-99): 2.32e-37: 143: 55.79		MK14_HUMAN (16-354): 1.6e-111: 330: 48.97
+	Hs
		840437 ETV1_HUMAN (4-90): 6.36e-23: 102: 60.92		MK14_HUMAN (16-354): 1.6e-111: 330: 48.97