HitPredict - High confidence protein-protein interactions

Interactor 1: CP3A4 (P08684)
Cytochrome P450 3A4 (EC 1.14.14.1) (1,4-cineole 2-exo-monooxygenase) (1,8-cineole 2-exo-monooxygenase) (EC 1.14.14.56) (Albendazole monooxygenase (sulfoxide-forming)) (EC 1.14.14.73) (Albendazole sulfoxidase) (CYPIIIA3) (CYPIIIA4) (Cholesterol 25-hydroxylase) (Cytochrome P450 3A3) (Cytochrome P450 HLp) (Cytochrome P450 NF-25) (Cytochrome P450-PCN1) (Nifedipine oxidase) (Quinine 3-monooxygenase) (EC 1.14.14.55)
Gene: CYP3A4

Interactor 2: CP3A4 (P08684)
Cytochrome P450 3A4 (EC 1.14.14.1) (1,4-cineole 2-exo-monooxygenase) (1,8-cineole 2-exo-monooxygenase) (EC 1.14.14.56) (Albendazole monooxygenase (sulfoxide-forming)) (EC 1.14.14.73) (Albendazole sulfoxidase) (CYPIIIA3) (CYPIIIA4) (Cholesterol 25-hydroxylase) (Cytochrome P450 3A3) (Cytochrome P450 HLp) (Cytochrome P450 NF-25) (Cytochrome P450-PCN1) (Nifedipine oxidase) (Quinine 3-monooxygenase) (EC 1.14.14.55)
Gene: CYP3A4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25451919
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	p450~p450
Common GO terms	GO:0002933 - lipid hydroxylation GO:0004497 - monooxygenase activity GO:0005496 - steroid binding GO:0005506 - iron ion binding GO:0005737 - cytoplasm and 38 others more... GO:0005789 - endoplasmic reticulum membrane GO:0006629 - lipid metabolic process GO:0006706 - steroid catabolic process GO:0006805 - xenobiotic metabolic process GO:0008202 - steroid metabolic process GO:0008203 - cholesterol metabolic process GO:0008209 - androgen metabolic process GO:0008210 - estrogen metabolic process GO:0008395 - steroid hydroxylase activity GO:0008401 - retinoic acid 4-hydroxylase activity GO:0009822 - alkaloid catabolic process GO:0016098 - monoterpenoid metabolic process GO:0016491 - oxidoreductase activity GO:0019825 - oxygen binding GO:0019899 - enzyme binding GO:0020037 - heme binding GO:0030343 - vitamin D3 25-hydroxylase activity GO:0034875 - caffeine oxidase activity GO:0042178 - xenobiotic catabolic process GO:0042359 - vitamin D metabolic process GO:0042369 - vitamin D catabolic process GO:0042572 - retinol metabolic process GO:0042573 - retinoic acid metabolic process GO:0042759 - long-chain fatty acid biosynthetic process GO:0043231 - intracellular membrane-bounded organelle GO:0046222 - aflatoxin metabolic process GO:0050591 - quinine 3-monooxygenase activity GO:0050649 - testosterone 6-beta-hydroxylase activity GO:0062181 - 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity GO:0062187 - anandamide 8,9 epoxidase activity GO:0062188 - anandamide 11,12 epoxidase activity GO:0062189 - anandamide 14,15 epoxidase activity GO:0070330 - aromatase activity GO:0070576 - vitamin D 24-hydroxylase activity GO:0070989 - oxidative demethylation GO:0101020 - estrogen 16-alpha-hydroxylase activity GO:0101021 - estrogen 2-hydroxylase activity GO:0102320 - 1,8-cineole 2-exo-monooxygenase activity
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1	503
Hs

1	503

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Last updated: 15 Jul 2024