HitPredict

Interactor 1: GNAI3 (P08754)
Guanine nucleotide-binding protein G(i) subunit alpha-3 (G(i) alpha-3)
Gene: GNAI3

Interactor 2: GBG3 (P63215)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
Gene: GNG3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17353931
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003924 - GTPase activity GO:0005834 - heterotrimeric G-protein complex GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 354 Hs			1 75
+	Hs
		926667 GNAI1_HUMAN (1-354): 4.65e-179: 502: 93.79		GBG3_HUMAN (1-75): 2.04e-30: 103: 100.00
+	Hs
		837675 GNAI1_HUMAN (1-354): 4.65e-179: 502: 93.79		GBG4_HUMAN (1-75): 4.61e-29: 100: 69.33
+	Hs
		887099 GNAI1_HUMAN (1-354): 4.65e-179: 502: 93.79		GBG2_HUMAN (5-75): 2.64e-28: 98.2: 76.06
+	Hs
		444694 GNAI3_HUMAN (1-354): 1.47e-176: 495: 100.00		GBG4_HUMAN (1-75): 4.61e-29: 100: 69.33
+	Hs
		391377 GNAI2_HUMAN (1-354): 2.82e-174: 489: 85.92		GBG3_HUMAN (1-75): 2.04e-30: 103: 100.00
+	Hs
		229239 GNAI1_HUMAN (1-354): 4.65e-179: 502: 93.79		GBG7_HUMAN (7-75): 5.89e-25: 89.3: 60.87
+	Hs
		926724 GNAI1_HUMAN (1-354): 4.65e-179: 502: 93.79		GBG8_HUMAN (7-75): 6.35e-25: 89.3: 56.52
+	Hs
		391359 GNAI2_HUMAN (1-354): 2.82e-174: 489: 85.92		GBG4_HUMAN (1-75): 4.61e-29: 100: 69.33
+	Hs
		391364 GNAI2_HUMAN (1-354): 2.82e-174: 489: 85.92		GBG2_HUMAN (5-75): 2.64e-28: 98.2: 76.06
+	Hs
		837689 GNAI1_HUMAN (1-354): 4.65e-179: 502: 93.79		GBG10_HUMAN (7-75): 2.48e-22: 82.8: 50.73
+	Hs
		229234 GNAI3_HUMAN (1-354): 1.47e-176: 495: 100.00		GBG7_HUMAN (7-75): 5.89e-25: 89.3: 60.87
+	Hs
		926668 GNAI1_HUMAN (1-354): 4.65e-179: 502: 93.79		GBG5_HUMAN (7-75): 1.42e-21: 80.9: 46.38
+	Hs
		229233 GNAI2_HUMAN (1-354): 2.82e-174: 489: 85.92		GBG7_HUMAN (7-75): 5.89e-25: 89.3: 60.87
+	Hs
		391482 GNAI2_HUMAN (1-354): 2.82e-174: 489: 85.92		GBG8_HUMAN (7-75): 6.35e-25: 89.3: 56.52
+	Hs
		444695 GNAI3_HUMAN (1-354): 1.47e-176: 495: 100.00		GBG10_HUMAN (7-75): 2.48e-22: 82.8: 50.73
+	Hs
		444710 GNAI3_HUMAN (1-354): 1.47e-176: 495: 100.00		GBG5_HUMAN (7-75): 1.42e-21: 80.9: 46.38
+	Hs
		391360 GNAI2_HUMAN (1-354): 2.82e-174: 489: 85.92		GBG10_HUMAN (7-75): 2.48e-22: 82.8: 50.73
+	Hs
		391378 GNAI2_HUMAN (1-354): 2.82e-174: 489: 85.92		GBG5_HUMAN (7-75): 1.42e-21: 80.9: 46.38
+	Hs
		450990 GNAO_HUMAN (1-354): 6.89e-171: 481: 71.27		GBG10_HUMAN (7-75): 2.48e-22: 82.8: 50.73
+	Hs
		444701 GNAI3_HUMAN (1-354): 1.47e-176: 495: 100.00		GBG11_HUMAN (5-74): 9.43e-16: 66.2: 31.51