Protein: FRAS1
Extracellular matrix organizing protein FRAS1 (Fraser syndrome 1 protein)

Gene: FRAS1
Organism: Homo sapiens
Interactions: 108
UniProt ID: Q86XX4

Gene Ontology (top 5):
GO:0002009 - morphogenesis of an epithelium
GO:0003338 - metanephros morphogenesis
GO:0005201 - extracellular matrix structural constituent
GO:0005604 - basement membrane
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1294397

PSG8
Pregnancy-specific beta-1-glycoprotein 8

2

20

High-throughput

0.726

High

168424

NCTR3
Natural cytotoxicity triggering receptor 3

1

4

High-throughput

0.691

High

731871

CEAM8
Cell adhesion molecule CEACAM8

1

20

High-throughput

0.691

High

1294376

SIRPD
Signal-regulatory protein delta

1

8

High-throughput

0.691

High

1294395

DKKL1
Dickkopf-like protein 1

3

11

High-throughput

0.662

High

1294398

PRG3
Proteoglycan 3

3

13

High-throughput

0.662

High

1294399

KLK5
Kallikrein-5

4

20

High-throughput

0.630

High

273771

ATS4
A disintegrin and metalloproteinase with thrombospondin motifs 4

2

20

High-throughput

0.628

High

1294374

GML
Glycosyl-phosphatidylinositol-anchored molecule-like protein

2

1

High-throughput

0.628

High

1160411

TAZ
Tafazzin

3

3

High-throughput

0.609

High

1219209

SUSD4
Sushi domain-containing protein 4

3

8

High-throughput

0.609

High

1294361

ZFP41
Zinc finger protein 41 homolog

3

20

High-throughput

0.609

High

1294372

GPHA2
Glycoprotein hormone alpha-2

3

3

High-throughput

0.609

High

1294390

MGT4C
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C

2

0

High-throughput

0.602

High

469810

CATG
Cathepsin G

2

20

High-throughput

0.601

High

480844

LEG1
Galectin-1

2

18

High-throughput

0.601

High

567906

PRG2
Bone marrow proteoglycan

2

16

High-throughput

0.601

High

663559

CMA1
Chymase

2

20

High-throughput

0.601

High

399455

TRGV3
T cell receptor gamma variable 3

1

4

High-throughput

0.575

High

351707

SG1D1
Secretoglobin family 1D member 1

2

4

High-throughput

0.574

High

1030797

DEF5
Defensin alpha 5

2

4

High-throughput

0.574

High

1248765

LYZL1
Lysozyme-like protein 1

2

3

High-throughput

0.574

High

1288317

LRRT1
Leucine-rich repeat transmembrane neuronal protein 1

2

4

High-throughput

0.574

High

1294367

SIA8D
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

2

4

High-throughput

0.574

High

1294381

ZN408
Zinc finger protein 408

2

20

High-throughput

0.574

High

327009

NXPH2
Neurexophilin-2

2

13

High-throughput

0.558

High

1294379

CHST8
Carbohydrate sulfotransferase 8

2

1

High-throughput

0.558

High

1294363

NET5
Netrin-5

2

20

High-throughput

0.549

High

1294394

FBX2
F-box only protein 2

2

15

High-throughput

0.549

High

64370

CDHR4
Cadherin-related family member 4

1

19

High-throughput

0.536

High

506867

CFC1
Cryptic protein

1

6

High-throughput

0.536

High

553361

FCGR1
High affinity immunoglobulin gamma Fc receptor I

1

13

High-throughput

0.536

High

664064

PRTN3
Myeloblastin

1

20

High-throughput

0.536

High

774779

TIMP3
Metalloproteinase inhibitor 3

1

6

High-throughput

0.536

High

908636

PRELP
Prolargin

1

7

High-throughput

0.536

High

945897

INHBE
Inhibin beta E chain

1

13

High-throughput

0.536

High

1030186

IL5RA
Interleukin-5 receptor subunit alpha

1

10

High-throughput

0.536

High

1101279

SLAF1
Signaling lymphocytic activation molecule

1

20

High-throughput

0.536

High

1250607

BCOR
BCL-6 corepressor

1

10

Small-scale

0.536

High

1279275

PODN
Podocan

1

4

High-throughput

0.536

High

1294358

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

5

High-throughput

0.536

High

1294360

LYPD1
Ly6/PLAUR domain-containing protein 1

1

4

High-throughput

0.536

High

1294362

ATS17
A disintegrin and metalloproteinase with thrombospondin motifs 17

1

20

High-throughput

0.536

High

1294364

HPSE2
Inactive heparanase-2

1

1

High-throughput

0.536

High

1294382

LRC4C
Leucine-rich repeat-containing protein 4C

1

9

High-throughput

0.536

High

1294385

B3GA2
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2

1

1

High-throughput

0.536

High

1294389

CBLN4
Cerebellin-4

1

18

High-throughput

0.536

High

1294396

ADA30
Disintegrin and metalloproteinase domain-containing protein 30

1

13

High-throughput

0.536

High

417552

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

2

1

High-throughput

0.533

High

951244

SC61B
Protein transport protein Sec61 subunit beta

2

3

High-throughput

0.533

High

1062537

DHX9
ATP-dependent RNA helicase A

1

3

High-throughput

0.515

High

1132163

ICAM4
Intercellular adhesion molecule 4

1

0

High-throughput

0.513

High

66797

C2C4B
C2 calcium-dependent domain-containing protein 4B

1

9

High-throughput

0.489

High

231051

VEGFD
Vascular endothelial growth factor D

1

9

High-throughput

0.489

High

327069

NXPH3
Neurexophilin-3

1

13

High-throughput

0.489

High

335363

CCN6
Cellular communication network factor 6

1

6

High-throughput

0.489

High

455653

KLK3
Prostate-specific antigen

1

20

High-throughput

0.489

High

854143

KI67
Proliferation marker protein Ki-67

1

4

High-throughput

0.489

High

909074

NEK4
Serine/threonine-protein kinase Nek4

1

6

High-throughput

0.489

High

1105499

OS9
Protein OS-9

1

1

High-throughput

0.489

High

1204558

NMS
Neuromedin-S

1

2

High-throughput

0.489

High

1225857

WDR25
WD repeat-containing protein 25

1

7

High-throughput

0.489

High

1249669

IGFL3
Insulin growth factor-like family member 3

1

5

High-throughput

0.489

High

1292594

IFNE
Interferon epsilon

1

3

High-throughput

0.489

High

1294359

ZN444
Zinc finger protein 444

1

20

High-throughput

0.489

High

1294368

GGH
Gamma-glutamyl hydrolase

1

5

High-throughput

0.489

High

1294371

ZN707
Zinc finger protein 707

1

20

High-throughput

0.489

High

1294377

CSTL1
Cystatin-like 1

1

8

High-throughput

0.489

High

1294383

SDF2L
Stromal cell-derived factor 2-like protein 1

1

9

High-throughput

0.489

High

1294384

XAGE1
X antigen family member 1

1

9

High-throughput

0.489

High

1294400

ZSC21
Zinc finger and SCAN domain-containing protein 21

1

20

High-throughput

0.489

High

218411

TGON2
Trans-Golgi network integral membrane protein 2

1

13

High-throughput

0.479

High

774477

BASI
Basigin

1

12

High-throughput

0.479

High

942185

WNT4
Protein Wnt-4

1

14

High-throughput

0.479

High

1113600

CUL3
Cullin-3

1

16

High-throughput

0.479

High

1144628

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

6

High-throughput

0.479

High

1294365

LIPH
Lipase member H

1

4

High-throughput

0.479

High

610752

TCPA
T-complex protein 1 subunit alpha

1

2

High-throughput

0.470

High

1294369

H2B1H
Histone H2B type 1-H

1

3

High-throughput

0.470

High

903993

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.458

High

1231720

PVRIG
Transmembrane protein PVRIG

1

0

High-throughput

0.458

High

379270

IGHG1
Immunoglobulin heavy constant gamma 1

1

6

High-throughput

0.445

High

1010939

BAT1
b(0,+)-type amino acid transporter 1

1

5

High-throughput

0.445

High

1294393

EGFL7
Epidermal growth factor-like protein 7

1

20

High-throughput

0.445

High

159732

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

9

High-throughput

0.437

High

173980

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

11

High-throughput

0.437

High

242185

PRKN
E3 ubiquitin-protein ligase parkin

1

6

High-throughput

0.437

High

274184

ANR17
Ankyrin repeat domain-containing protein 17

1

8

High-throughput

0.437

High

418248

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.437

High

693829

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.437

High

894876

EMD
Emerin

1

1

High-throughput

0.437

High

1067483

EP300
Histone acetyltransferase p300

1

9

High-throughput

0.437

High

1294373

SEC62
Translocation protein SEC62

1

3

High-throughput

0.437

High

1294375

DERL1
Derlin-1

1

3

High-throughput

0.437

High

1294378

DJC25
DnaJ homolog subfamily C member 25

1

8

High-throughput

0.437

High

1294380

WDR76
WD repeat-containing protein 76

1

6

High-throughput

0.437

High

1294386

ST7
Suppressor of tumorigenicity 7 protein

1

2

High-throughput

0.437

High

1294387

FBX6
F-box only protein 6

1

15

High-throughput

0.437

High

1294391

KLK11
Kallikrein-11

1

20

High-throughput

0.437

High

1294392

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.437

High

167457

WNT9A
Protein Wnt-9a

1

14

High-throughput

0.407

High

183679

RT12
Small ribosomal subunit protein uS12m

1

8

High-throughput

0.407

High

1159262

ZNF74
Zinc finger protein 74

1

16

High-throughput

0.407

High

1294366

PATE1
Prostate and testis expressed protein 1

1

1

High-throughput

0.407

High

1294370

EMID1
EMI domain-containing protein 1

1

13

High-throughput

0.407

High

1294388

CAH10
Carbonic anhydrase-related protein 10

1

2

High-throughput

0.407

High

1162728

QPCT
Glutaminyl-peptide cyclotransferase

3

0

High-throughput

0.335

High

1250920

ZPBP2
Zona pellucida-binding protein 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025