HitPredict

Interactor 1: K1C16 (P08779)
Keratin, type I cytoskeletal 16 (Cytokeratin-16) (CK-16) (Keratin-16) (K16)
Gene: KRT16

Interactor 2: AINX (Q16352)
Alpha-internexin (Alpha-Inx) (66 kDa neurofilament protein) (NF-66) (Neurofilament-66) (Neurofilament 5)
Gene: INA

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Filament~Filament
Common GO terms	GO:0005200 - structural constituent of cytoskeleton GO:0005882 - intermediate filament GO:0045109 - intermediate filament organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 473 Hs			1 499
+	Hs
		422329 K1C16_HUMAN (1-461): 1.58e-161: 467: 100.00		NFM_HUMAN (9-480): 1.71e-96: 313: 47.43
+	Hs
		445013 K1C16_HUMAN (1-461): 1.58e-161: 467: 100.00		PERI_HUMAN (11-430): 6.23e-88: 279: 50.12
+	Hs
		445028 K1C16_HUMAN (1-461): 1.58e-161: 467: 100.00		KRT83_HUMAN (5-415): 2.39e-81: 263: 30.17
+	Hs
		445046 K1C16_HUMAN (1-461): 1.58e-161: 467: 100.00		KRT81_HUMAN (5-415): 6.99e-81: 262: 29.93
+	Hs
		445029 K1C16_HUMAN (1-461): 1.58e-161: 467: 100.00		KRT85_HUMAN (5-415): 4.25e-80: 260: 31.16
+	Hs
		213927 K1C16_HUMAN (1-461): 1.58e-161: 467: 100.00		KRT86_HUMAN (5-415): 1.75e-79: 257: 30.17
+	Hs
		445082 K1C16_HUMAN (1-461): 1.58e-161: 467: 100.00		K2C73_HUMAN (7-410): 3.68e-78: 255: 31.88
+	Hs
		213930 K1C15_HUMAN (116-429): 2.97e-155: 450: 76.19		KRT86_HUMAN (5-415): 1.75e-79: 257: 30.17
+	Hs
		318770 K1C16_HUMAN (1-461): 1.58e-161: 467: 100.00		K2C75_HUMAN (2-410): 2.98e-71: 238: 30.92
+	Hs
		445129 K1C16_HUMAN (1-461): 1.58e-161: 467: 100.00		KRT82_HUMAN (35-409): 1.55e-70: 235: 29.26
+	Hs
		445068 K1C16_HUMAN (1-461): 1.58e-161: 467: 100.00		K2C79_HUMAN (10-418): 7.42e-69: 231: 29.02
+	Hs
		445061 K1C16_HUMAN (1-461): 1.58e-161: 467: 100.00		K2C71_HUMAN (5-410): 4.39e-67: 226: 30.19
+	Hs
		318776 K1C15_HUMAN (116-429): 2.97e-155: 450: 76.19		K2C75_HUMAN (2-410): 2.98e-71: 238: 30.92
+	Hs
		445048 K1C16_HUMAN (1-461): 1.58e-161: 467: 100.00		K2C72_HUMAN (10-410): 1.71e-64: 219: 29.53
+	Hs
		445078 K1C16_HUMAN (1-461): 1.58e-161: 467: 100.00		K2C74_HUMAN (30-410): 1.38e-59: 206: 31.59
+	Hs
		380438 K1C16_HUMAN (1-461): 1.58e-161: 467: 100.00		K2C6B_HUMAN (59-410): 7.35e-59: 205: 30.23
+	Hs
		445000 K1C16_HUMAN (1-461): 1.58e-161: 467: 100.00		K2C5_HUMAN (59-410): 8.69e-59: 205: 31.07
+	Hs
		445017 K1C16_HUMAN (1-461): 1.58e-161: 467: 100.00		K2C6C_HUMAN (59-410): 7.2e-59: 205: 30.51
+	Hs
		359454 K1C16_HUMAN (1-461): 1.58e-161: 467: 100.00		K2C6A_HUMAN (59-410): 3.18e-57: 201: 30.51
+	Hs
		359463 K1C15_HUMAN (116-429): 2.97e-155: 450: 76.19		K2C6A_HUMAN (59-410): 3.18e-57: 201: 30.51