Protein: S10A8
Protein S100-A8 (Calgranulin-A) (Calprotectin L1L subunit) (Cystic fibrosis antigen) (CFAG) (Leukocyte L1 complex light chain) (Migration inhibitory factor-related protein 8) (MRP-8) (p8) (S100 calcium-binding protein A8) (Urinary stone protein band A)

Gene: S10A8, S100A8
Organism: Homo sapiens
Interactions: 212
UniProt ID: P05109

Gene Ontology (top 5):
GO:0002523 - leukocyte migration involved in inflammatory response
GO:0002544 - chronic inflammatory response
GO:0002790 - peptide secretion
GO:0002793 - positive regulation of peptide secretion
GO:0005509 - calcium ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

424117

S10A9
Protein S100-A9

10

18

Small-scale

0.970

High

413004

P53
Cellular tumor antigen p53

3

15

Small-scale

0.854

High

424116

S10A8
Protein S100-A8

2

18

Small-scale

0.767

High

424125

CFTR
Cystic fibrosis transmembrane conductance regulator

3

7

High-throughput

0.662

High

424186

MERTK
Tyrosine-protein kinase Mer

1

5

High-throughput

0.646

High

424118

ANXA2
Annexin A2

1

12

High-throughput

0.618

High

424142

S10A7
Protein S100-A7

1

18

High-throughput

0.618

High

424176

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

2

6

High-throughput

0.612

High

424140

SHC1
SHC-transforming protein 1

2

13

High-throughput

0.611

High

424260

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

2

15

High-throughput

0.611

High

424225

CCYL1
Cyclin-Y-like protein 1

2

0

High-throughput

0.602

High

424259

EFHD1
EF-hand domain-containing protein D1

2

0

High-throughput

0.602

High

395315

ESR1
Estrogen receptor

2

17

High-throughput

0.601

High

424137

CDK2
Cyclin-dependent kinase 2

2

10

High-throughput

0.584

High

424254

RNF5
E3 ubiquitin-protein ligase RNF5

2

13

Small-scale

0.584

High

424287

FBW1A
F-box/WD repeat-containing protein 1A

2

6

High-throughput

0.584

High

408609

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

2

Small-scale

0.579

High

424132

VCAM1
Vascular cell adhesion protein 1

1

1

High-throughput

0.575

High

424205

SMTL2
Smoothelin-like protein 2

2

2

High-throughput

0.574

High

424275

TB22B
TBC1 domain family member 22B

2

5

High-throughput

0.574

High

174208

ARHGA
Rho guanine nucleotide exchange factor 10

2

3

High-throughput

0.571

High

424180

OCRL
Inositol polyphosphate 5-phosphatase OCRL

2

1

High-throughput

0.571

High

424221

SLX4
Structure-specific endonuclease subunit SLX4

2

5

High-throughput

0.571

High

424227

DOCK8
Dedicator of cytokinesis protein 8

2

4

High-throughput

0.571

High

424123

TAU
Microtubule-associated protein tau

2

15

Small-scale

0.552

High

248377

GDF9
Growth/differentiation factor 9

1

3

High-throughput

0.541

High

424171

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

5

High-throughput

0.541

High

424190

U119A
Protein unc-119 homolog A

1

1

High-throughput

0.541

High

424253

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.541

High

132552

UPK1A
Uroplakin-1a

1

7

High-throughput

0.536

High

210678

KLK10
Kallikrein-10

1

8

High-throughput

0.536

High

222344

TSN6
Tetraspanin-6

1

4

High-throughput

0.536

High

292520

RENR
Renin receptor

1

3

High-throughput

0.536

High

352664

NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

1

2

High-throughput

0.536

High

424130

AATC
Aspartate aminotransferase, cytoplasmic

1

4

High-throughput

0.536

High

424133

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

9

High-throughput

0.536

High

424145

CCR1
C-C chemokine receptor type 1

1

5

High-throughput

0.536

High

424149

RYK
Tyrosine-protein kinase RYK

1

7

High-throughput

0.536

High

424150

CNR2
Cannabinoid receptor 2

1

1

Small-scale

0.536

High

424151

CTNB1
Catenin beta-1

1

7

High-throughput

0.536

High

424163

GSK3B
Glycogen synthase kinase-3 beta

1

5

High-throughput

0.536

High

424168

DSCR6
Protein ripply3

1

6

High-throughput

0.536

High

424172

GRB2
Growth factor receptor-bound protein 2

1

4

High-throughput

0.536

High

424174

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

6

High-throughput

0.536

High

424183

GABPA
GA-binding protein alpha chain

1

6

High-throughput

0.536

High

424184

DMWD
Dystrophia myotonica WD repeat-containing protein

1

2

High-throughput

0.536

High

424204

IF16
Gamma-interferon-inducible protein 16

1

2

High-throughput

0.536

High

424217

DPH6
Diphthine--ammonia ligase

1

1

High-throughput

0.536

High

424218

APTX
Aprataxin

1

2

High-throughput

0.536

High

424226

FNDC5
Fibronectin type III domain-containing protein 5

1

7

High-throughput

0.536

High

424231

RHBL4
Rhomboid-related protein 4

1

4

High-throughput

0.536

High

424234

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

4

High-throughput

0.536

High

424241

CSN5
COP9 signalosome complex subunit 5

1

5

High-throughput

0.536

High

424247

PF21B
PHD finger protein 21B

1

16

High-throughput

0.536

High

424252

EPAS1
Endothelial PAS domain-containing protein 1

1

5

High-throughput

0.536

High

424258

MMTA2
Multiple myeloma tumor-associated protein 2

1

3

High-throughput

0.536

High

424271

KMT5A
N-lysine methyltransferase KMT5A

1

10

High-throughput

0.536

High

424281

PHF11
PHD finger protein 11

1

9

High-throughput

0.536

High

424289

SSUH2
Protein SSUH2 homolog

1

2

High-throughput

0.536

High

424135

NCF2
Neutrophil cytosol factor 2

1

8

Small-scale

0.527

High

421136

SCG1
Secretogranin-1

1

0

High-throughput

0.518

High

424196

RRP5
Protein RRP5 homolog

1

0

High-throughput

0.518

High

244216

NUAK1
NUAK family SNF1-like kinase 1

1

3

High-throughput

0.515

High

290832

PPM1B
Protein phosphatase 1B

1

2

High-throughput

0.515

High

424203

USF2
Upstream stimulatory factor 2

1

11

High-throughput

0.515

High

424207

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

1

5

High-throughput

0.515

High

424269

MOB1A
MOB kinase activator 1A

1

2

High-throughput

0.515

High

424121

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

424222

S15A4
Solute carrier family 15 member 4

1

0

Small-scale

0.513

High

424230

MIPT3
TRAF3-interacting protein 1

1

0

Small-scale

0.513

High

424256

SLX1
Structure-specific endonuclease subunit SLX1

1

0

High-throughput

0.513

High

424279

WRP73
WD repeat-containing protein WRAP73

1

0

High-throughput

0.513

High

421287

A4
Amyloid-beta precursor protein

1

4

High-throughput

0.501

High

424119

TBB5
Tubulin beta chain

1

1

Small-scale

0.501

High

424146

NAC1
Sodium/calcium exchanger 1

1

16

Small-scale

0.501

High

424170

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

2

Small-scale

0.501

High

424216

TBA1A
Tubulin alpha-1A chain

1

4

Small-scale

0.501

High

424229

TRPM4
Transient receptor potential cation channel subfamily M member 4

1

12

Small-scale

0.501

High

424120

MET
Hepatocyte growth factor receptor

1

8

High-throughput

0.500

High

325261

OR2A4
Olfactory receptor 2A4

1

5

High-throughput

0.489

High

424161

PTSS1
Phosphatidylserine synthase 1

1

6

High-throughput

0.489

High

424206

CR021
UPF0711 protein C18orf21

1

4

High-throughput

0.489

High

424244

PIGT
GPI-anchor transamidase component PIGT

1

2

High-throughput

0.489

High

424245

SARAF
Store-operated calcium entry-associated regulatory factor

1

2

High-throughput

0.489

High

424255

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

3

High-throughput

0.489

High

424257

SH23A
SH2 domain-containing protein 3A

1

12

High-throughput

0.489

High

424272

ST7
Suppressor of tumorigenicity 7 protein

1

3

High-throughput

0.489

High

424156

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

High-throughput

0.486

High

424152

NOS2
Nitric oxide synthase, inducible

1

1

Small-scale

0.484

High

424124

PCNA
Proliferating cell nuclear antigen

1

0

Small-scale

0.480

High

181770

EPHB6
Ephrin type-B receptor 6

1

2

High-throughput

0.479

High

240478

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.479

High

246390

KDM1A
Lysine-specific histone demethylase 1A

1

1

High-throughput

0.479

High

293049

CD123
Translation initiation factor eIF2 assembly protein

1

8

High-throughput

0.479

High

302316

RNF8
E3 ubiquitin-protein ligase RNF8

1

17

High-throughput

0.479

High

324402

HEXI1
Protein HEXIM1

1

1

High-throughput

0.479

High

347460

BAG3
BAG family molecular chaperone regulator 3

1

5

High-throughput

0.479

High

352837

AGR2
Anterior gradient protein 2 homolog

1

4

Small-scale

0.479

High

370257

CYTA
Cystatin-A

1

2

High-throughput

0.479

High

370910

MYC
Myc proto-oncogene protein

1

11

High-throughput

0.479

High

375084

RASK
GTPase KRas

1

5

High-throughput

0.479

High

390979

TRFL
Lactotransferrin

1

1

High-throughput

0.479

High

400103

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

9

High-throughput

0.479

High

403729

GCR
Glucocorticoid receptor

1

16

Small-scale

0.479

High

424122

H2A1
Histone H2A type 1

1

2

High-throughput

0.479

High

424126

INSRR
Insulin receptor-related protein

1

9

High-throughput

0.479

High

424127

RAC2
Ras-related C3 botulinum toxin substrate 2

1

7

Small-scale

0.479

High

424128

TIMP2
Metalloproteinase inhibitor 2

1

1

High-throughput

0.479

High

424134

RO52
E3 ubiquitin-protein ligase TRIM21

1

9

High-throughput

0.479

High

424136

SPR2E
Small proline-rich protein 2E

1

1

High-throughput

0.479

High

424138

ZA2G
Zinc-alpha-2-glycoprotein

1

1

High-throughput

0.479

High

424139

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

5

High-throughput

0.479

High

424141

SPB3
Serpin B3

1

7

High-throughput

0.479

High

424144

CASPE
Caspase-14

1

4

High-throughput

0.479

High

424147

ELF1
ETS-related transcription factor Elf-1

1

6

High-throughput

0.479

High

424148

MCM5
DNA replication licensing factor MCM5

1

8

High-throughput

0.479

High

424153

MERL
Merlin

1

5

High-throughput

0.479

High

424155

ACVL1
Activin receptor type-1-like

1

2

Small-scale

0.479

High

424157

CEAM3
Cell adhesion molecule CEACAM3

1

1

Small-scale

0.479

High

424158

VHL
von Hippel-Lindau disease tumor suppressor

1

3

High-throughput

0.479

High

424159

LEG7
Galectin-7

1

4

High-throughput

0.479

High

424160

SPB4
Serpin B4

1

7

High-throughput

0.479

High

424162

MCM2
DNA replication licensing factor MCM2

1

8

High-throughput

0.479

High

424166

TERF1
Telomeric repeat-binding factor 1

1

2

High-throughput

0.479

High

424169

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

6

High-throughput

0.479

High

424173

RAC1
Ras-related C3 botulinum toxin substrate 1

1

7

Small-scale

0.479

High

424177

HSF1
Heat shock factor protein 1

1

5

High-throughput

0.479

High

424178

FABP5
Fatty acid-binding protein 5

1

2

High-throughput

0.479

High

424179

TFAP4
Transcription factor AP-4

1

1

Small-scale

0.479

High

424181

TNAP2
Tumor necrosis factor alpha-induced protein 2

1

1

Small-scale

0.479

High

424182

K1C17
Keratin, type I cytoskeletal 17

1

3

High-throughput

0.479

High

424187

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

8

High-throughput

0.479

High

424188

NFX1
Transcriptional repressor NF-X1

1

2

High-throughput

0.479

High

424189

ERCC8
DNA excision repair protein ERCC-8

1

4

Small-scale

0.479

High

424191

BIRC3
Baculoviral IAP repeat-containing protein 3

1

4

High-throughput

0.479

High

424192

CUL2
Cullin-2

1

9

High-throughput

0.479

High

424193

DX39B
Spliceosome RNA helicase DDX39B

1

8

High-throughput

0.479

High

424194

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

11

High-throughput

0.479

High

424197

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

8

High-throughput

0.479

High

424198

TNIP1
TNFAIP3-interacting protein 1

1

20

High-throughput

0.479

High

424201

TERF2
Telomeric repeat-binding factor 2

1

2

High-throughput

0.479

High

424202

IKBB
NF-kappa-B inhibitor beta

1

2

High-throughput

0.479

High

424212

OTU1
Ubiquitin thioesterase OTU1

1

2

High-throughput

0.479

High

424213

VIR
Protein virilizer homolog

1

3

High-throughput

0.479

High

424214

TRI67
Tripartite motif-containing protein 67

1

19

High-throughput

0.479

High

424215

PAXI1
PAX-interacting protein 1

1

7

High-throughput

0.479

High

424219

ZN598
E3 ubiquitin-protein ligase ZNF598

1

4

High-throughput

0.479

High

424220

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

1

10

Small-scale

0.479

High

424224

SIR6
NAD-dependent protein deacylase sirtuin-6

1

2

Small-scale

0.479

High

424228

COP1
E3 ubiquitin-protein ligase COP1

1

3

High-throughput

0.479

High

424232

TP4AP
Short transient receptor potential channel 4-associated protein

1

2

High-throughput

0.479

High

424237

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

7

High-throughput

0.479

High

424238

TOPB1
DNA topoisomerase 2-binding protein 1

1

6

High-throughput

0.479

High

424239

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

1

High-throughput

0.479

High

424240

HDAC2
Histone deacetylase 2

1

6

High-throughput

0.479

High

424243

FBXW7
F-box/WD repeat-containing protein 7

1

6

High-throughput

0.479

High

424248

AURKB
Aurora kinase B

1

9

High-throughput

0.479

High

424251

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

6

High-throughput

0.479

High

424261

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.479

High

424262

ACE2
Angiotensin-converting enzyme 2

1

4

High-throughput

0.479

High

424263

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

1

High-throughput

0.479

High

424264

DDX24
ATP-dependent RNA helicase DDX24

1

9

High-throughput

0.479

High

424268

DOCK5
Dedicator of cytokinesis protein 5

1

4

High-throughput

0.479

High

424270

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

5

High-throughput

0.479

High

424273

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

2

High-throughput

0.479

High

424274

TMPS4
Transmembrane protease serine 4

1

3

High-throughput

0.479

High

424278

MARH2
E3 ubiquitin-protein ligase MARCHF2

1

2

High-throughput

0.479

High

424280

ZRAN1
Ubiquitin thioesterase ZRANB1

1

11

High-throughput

0.479

High

424282

MBD1
Methyl-CpG-binding domain protein 1

1

4

Small-scale

0.479

High

424283

RALY
RNA-binding protein Raly

1

2

High-throughput

0.479

High

424285

RL26L
Ribosomal protein uL24-like

1

1

High-throughput

0.479

High

424286

MOK
MAPK/MAK/MRK overlapping kinase

1

10

Small-scale

0.479

High

424288

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

10

Small-scale

0.479

High

424290

RNF11
RING finger protein 11

1

6

Small-scale

0.479

High

424291

RL36
Large ribosomal subunit protein eL36

1

1

High-throughput

0.479

High

424292

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.479

High

424293

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

3

Small-scale

0.479

High

424294

LOXL2
Lysyl oxidase homolog 2

1

3

High-throughput

0.479

High

424295

ASB3
Ankyrin repeat and SOCS box protein 3

1

4

High-throughput

0.479

High

424131

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.458

High

424165

ATX3
Ataxin-3

1

0

High-throughput

0.458

High

424185

RBBP4
Histone-binding protein RBBP4

1

0

High-throughput

0.458

High

424195

BECN1
Beclin-1

1

0

Small-scale

0.458

High

424199

ELOC
Elongin-C

1

0

High-throughput

0.458

High

424200

ELOB
Elongin-B

1

0

High-throughput

0.458

High

424235

CEMIP
Cell migration-inducing and hyaluronan-binding protein

1

0

Small-scale

0.458

High

424242

TF3B
Transcription factor IIIB 90 kDa subunit

1

0

Small-scale

0.458

High

424246

GCP3
Gamma-tubulin complex component 3

1

0

High-throughput

0.458

High

424129

ZNF16
Zinc finger protein 16

1

2

Small-scale

0.457

High

424175

TBA4A
Tubulin alpha-4A chain

1

4

High-throughput

0.457

High

424211

RIF1
Telomere-associated protein RIF1

1

1

High-throughput

0.457

High

424265

KLC2
Kinesin light chain 2

1

10

High-throughput

0.457

High

424267

RAB17
Ras-related protein Rab-17

1

3

High-throughput

0.457

High

424143

SC6A6
Sodium- and chloride-dependent taurine transporter

1

1

High-throughput

0.445

High

424164

GPC3
Glypican-3

1

5

High-throughput

0.445

High

424167

TERA
Transitional endoplasmic reticulum ATPase

1

4

High-throughput

0.445

High

424208

ODFP2
Outer dense fiber protein 2

1

19

High-throughput

0.445

High

424209

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

5

High-throughput

0.445

High

424223

CD177
CD177 antigen

1

1

Small-scale

0.445

High

424233

CE192
Centrosomal protein of 192 kDa

1

4

High-throughput

0.445

High

424266

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

14

High-throughput

0.445

High

105112

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

424154

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

424236

DCAF4
DDB1- and CUL4-associated factor 4

1

1

High-throughput

0.437

High

424250

LMTK3
Serine/threonine-protein kinase LMTK3

1

7

High-throughput

0.437

High

424276

POTE1
Protection of telomeres protein 1

1

1

High-throughput

0.437

High

424277

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

4

High-throughput

0.437

High

87299

OSCRI
SCRIB overlapping open reading frame protein

1

1

High-throughput

0.407

High

424249

IGS21
Immunoglobulin superfamily member 21

1

0

High-throughput

0.282

High

424284

ERG28
Ergosterol biosynthetic protein 28 homolog

1

0

High-throughput

0.282

High

424210

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

High-throughput

0.251

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025