HitPredict

Interactor 1: ROS1 (P08922)
Proto-oncogene tyrosine-protein kinase ROS (EC 2.7.10.1) (Proto-oncogene c-Ros) (Proto-oncogene c-Ros-1) (Receptor tyrosine kinase c-ros oncogene 1) (c-Ros receptor tyrosine kinase)
Gene: ROS1

Interactor 2: PRKDC (P78527)
DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (p460)
Gene: PRKDC

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0006468 - protein phosphorylation GO:0016020 - membrane
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 2347 Hs			1 4128
+	Hs
		665578 EPHB2_HUMAN (1381-2344): 0: 601: 18.74		PRKDC_HUMAN (1-4128): 0: 6819: 100.00
+	Hs
		435610 IGF1R_HUMAN (1442-2307): 3.63e-161: 538: 23.25		PRKDC_HUMAN (1-4128): 0: 6819: 100.00
+	Hs
		600550 EPHA1_HUMAN (1385-2265): 9.45e-155: 509: 19.40		PRKDC_HUMAN (1-4128): 0: 6819: 100.00
+	Hs
		601494 FGFR2_HUMAN (1539-2270): 2.63e-154: 502: 23.38		PRKDC_HUMAN (1-4128): 0: 6819: 100.00
+	Hs
		944199 TYRO3_HUMAN (1514-2218): 1.53e-145: 479: 23.85		PRKDC_HUMAN (1-4128): 0: 6819: 100.00
+	Hs
		944192 TIE2_HUMAN (1622-2244): 6.15e-134: 453: 26.28		PRKDC_HUMAN (1-4128): 0: 6819: 100.00
+	Hs
		674388 UFO_HUMAN (1633-2297): 6.04e-130: 434: 25.83		PRKDC_HUMAN (1-4128): 0: 6819: 100.00
+	Hs
		609246 FGFR3_HUMAN (1886-2215): 4.22e-59: 222: 38.73		PRKDC_HUMAN (1-4128): 0: 6819: 100.00
+	Hs
		445886 ROS1_HUMAN (1-2347): 0: 2848: 100.00		TRRAP_HUMAN (2754-4128): 0: 828: 15.88
+	Hs
		872435 EPHA5_HUMAN (1360-2290): 0: 586: 19.28		ATM_HUMAN (3218-4128): 1.84e-158: 557: 19.42
+	Hs
		600653 EPHA1_HUMAN (1385-2265): 9.45e-155: 509: 19.40		SMG1_HUMAN (3179-4115): 6.6e-124: 444: 16.20