Protein: ENOG
Gamma-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 2) (Neural enolase) (Neuron-specific enolase) (NSE)

Gene: ENOG, ENO2
Organism: Homo sapiens
Interactions: 91
UniProt ID: P09104

Gene Ontology (top 5):
GO:0000015 - phosphopyruvate hydratase complex
GO:0000287 - magnesium ion binding
GO:0001917 - photoreceptor inner segment
GO:0004634 - phosphopyruvate hydratase activity
GO:0005615 - extracellular space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

445689

ENOA
Alpha-enolase

10

13

High-throughput

0.973

High

479104

ENOB
Beta-enolase

4

13

High-throughput

0.895

High

479115

AKT1
RAC-alpha serine/threonine-protein kinase

2

3

Small-scale

0.614

High

479102

TAU
Microtubule-associated protein tau

2

6

High-throughput

0.611

High

479150

CAND1
Cullin-associated NEDD8-dissociated protein 1

2

3

Small-scale

0.611

High

479110

HXK1
Hexokinase-1

1

5

High-throughput

0.541

High

479114

MAP4
Microtubule-associated protein 4

1

8

High-throughput

0.541

High

479123

ANX11
Annexin A11

1

2

High-throughput

0.541

High

479128

TBA4A
Tubulin alpha-4A chain

1

2

High-throughput

0.541

High

479129

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.541

High

479146

HABP4
Intracellular hyaluronan-binding protein 4

1

1

High-throughput

0.541

High

479103

PIM1
Serine/threonine-protein kinase pim-1

1

4

High-throughput

0.536

High

479111

SAHH
Adenosylhomocysteinase

1

1

High-throughput

0.536

High

479119

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

7

High-throughput

0.536

High

479126

PCBP3
Poly(rC)-binding protein 3

1

1

High-throughput

0.536

High

479133

MK07
Mitogen-activated protein kinase 7

1

2

High-throughput

0.536

High

479135

CUL1
Cullin-1

1

10

High-throughput

0.536

High

479136

CUL2
Cullin-2

1

10

High-throughput

0.536

High

479137

CUL3
Cullin-3

1

10

High-throughput

0.536

High

479139

CUL4B
Cullin-4B

1

10

High-throughput

0.536

High

479141

NTRK3
NT-3 growth factor receptor

1

3

High-throughput

0.536

High

479125

TERF1
Telomeric repeat-binding factor 1

1

0

High-throughput

0.529

High

479159

ACD
Adrenocortical dysplasia protein homolog

1

0

High-throughput

0.529

High

144157

UBE2C
Ubiquitin-conjugating enzyme E2 C

1

0

High-throughput

0.518

High

275235

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

1

0

High-throughput

0.518

High

326811

SPN1
Snurportin-1

1

0

High-throughput

0.518

High

479143

SIA4B
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2

1

0

High-throughput

0.518

High

479147

SIGIR
Single Ig IL-1-related receptor

1

0

High-throughput

0.518

High

479174

IL17B
Interleukin-17B

1

0

High-throughput

0.518

High

479130

UBE3A
Ubiquitin-protein ligase E3A

1

7

Small-scale

0.501

High

479161

MERB1
bMERB domain-containing protein 1

1

1

High-throughput

0.494

High

479175

AURKC
Aurora kinase C

1

3

High-throughput

0.489

High

479121

MTR1A
Melatonin receptor type 1A

1

0

High-throughput

0.486

High

137174

EXOC5
Exocyst complex component 5

1

1

High-throughput

0.481

High

411225

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.479

High

479105

KPYM
Pyruvate kinase PKM

1

4

Small-scale

0.479

High

479106

EZRI
Ezrin

1

2

High-throughput

0.479

High

479108

IL7RA
Interleukin-7 receptor subunit alpha

1

1

High-throughput

0.479

High

479109

NELFE
Negative elongation factor E

1

2

High-throughput

0.479

High

479112

CDK2
Cyclin-dependent kinase 2

1

5

High-throughput

0.479

High

479118

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

2

Small-scale

0.479

High

479120

YAP1
Transcriptional coactivator YAP1

1

12

High-throughput

0.479

High

479122

PPT1
Palmitoyl-protein thioesterase 1

1

1

High-throughput

0.479

High

479124

GDIR1
Rho GDP-dissociation inhibitor 1

1

1

High-throughput

0.479

High

479131

TFCP2
Alpha-globin transcription factor CP2

1

2

High-throughput

0.479

High

479140

EZH2
Histone-lysine N-methyltransferase EZH2

1

4

High-throughput

0.479

High

479144

MIC60
MICOS complex subunit MIC60

1

1

High-throughput

0.479

High

479145

LARP7
La-related protein 7

1

4

High-throughput

0.479

High

479148

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

2

High-throughput

0.479

High

479157

ASB5
Ankyrin repeat and SOCS box protein 5

1

4

High-throughput

0.479

High

479158

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

4

High-throughput

0.479

High

479160

ASB9
Ankyrin repeat and SOCS box protein 9

1

4

High-throughput

0.479

High

479162

BAG1
BAG family molecular chaperone regulator 1

1

1

High-throughput

0.479

High

479167

CPAP
Centrosomal P4.1-associated protein

1

7

High-throughput

0.479

High

479169

BRD7
Bromodomain-containing protein 7

1

2

High-throughput

0.479

High

479173

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

369593

A2MG
Alpha-2-macroglobulin

1

0

High-throughput

0.460

High

479117

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.458

High

479142

FSCN1
Fascin

1

0

High-throughput

0.458

High

479168

NGB
Neuroglobin

1

0

High-throughput

0.458

High

327750

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

8

High-throughput

0.445

High

479116

BMI1
Polycomb complex protein BMI-1

1

3

High-throughput

0.445

High

479127

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

8

High-throughput

0.445

High

479165

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

8

High-throughput

0.445

High

479166

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

8

High-throughput

0.445

High

479170

ITM2C
Integral membrane protein 2C

1

1

High-throughput

0.445

High

479171

DDX28
Probable ATP-dependent RNA helicase DDX28

1

3

High-throughput

0.445

High

479176

GAB2
GRB2-associated-binding protein 2

1

3

High-throughput

0.445

High

105167

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

324441

HEXI1
Protein HEXIM1

1

2

High-throughput

0.437

High

479132

TADBP
TAR DNA-binding protein 43

1

1

Small-scale

0.437

High

479138

CUL4A
Cullin-4A

1

10

High-throughput

0.437

High

479149

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.437

High

479152

RHG24
Rho GTPase-activating protein 24

1

2

High-throughput

0.437

High

479155

POC1A
POC1 centriolar protein homolog A

1

2

High-throughput

0.437

High

125167

LEG9
Galectin-9

1

0

High-throughput

0.426

High

479107

ANFB
Natriuretic peptides B

1

0

High-throughput

0.426

High

479113

CD27
CD27 antigen

1

0

High-throughput

0.426

High

479151

DND1
Dead end protein homolog 1

1

0

High-throughput

0.426

High

479156

TGFA1
Transforming growth factor-beta receptor-associated protein 1

1

0

High-throughput

0.426

High

346596

TTC4
Tetratricopeptide repeat protein 4

1

6

High-throughput

0.407

High

479154

TTC9C
Tetratricopeptide repeat protein 9C

1

2

High-throughput

0.407

High

479163

TINF2
TERF1-interacting nuclear factor 2

1

0

High-throughput

0.299

High

479172

POTE1
Protection of telomeres protein 1

1

0

High-throughput

0.288

High

226949

ENSA
Alpha-endosulfine

1

0

High-throughput

0.282

High

350521

CF047
Uncharacterized protein C6orf47

1

0

High-throughput

0.282

High

479164

NAT9
Alpha/beta-tubulin-N-acetyltransferase 9

1

0

High-throughput

0.282

High

326197

ALX3
Homeobox protein aristaless-like 3

1

0

High-throughput

0.279

Low

330021

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.232

Low

479134

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low

479153

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025