HitPredict

Interactor 1: ROS1 (P08922)
Proto-oncogene tyrosine-protein kinase ROS (EC 2.7.10.1) (Proto-oncogene c-Ros) (Proto-oncogene c-Ros-1) (Receptor tyrosine kinase c-ros oncogene 1) (c-Ros receptor tyrosine kinase)
Gene: ROS1

Interactor 2: OSBL8 (Q9BZF1)
Oxysterol-binding protein-related protein 8 (ORP-8) (OSBP-related protein 8)
Gene: OSBPL8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.646

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	GO:0016020 - membrane
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 2347 Hs			1 889
+	Hs
		665522 EPHA8_HUMAN (1383-2242): 1.9e-173: 562: 18.61		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		411491 INSR_HUMAN (1424-2308): 7.33e-167: 555: 23.13		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		435752 IGF1R_HUMAN (1442-2307): 3.63e-161: 538: 23.25		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		537771 INSRR_HUMAN (1472-2261): 4.5e-161: 536: 24.97		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		537772 INSRR_HUMAN (1472-2261): 4.5e-161: 536: 24.97		OSBL5_HUMAN (32-889): 0: 1012: 54.21
+	Hs
		1318012 ALK_HUMAN (1858-2311): 4.31e-84: 309: 38.96		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		434280 RET_HUMAN (1940-2216): 6.4e-64: 241: 42.76		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		435736 IGF1R_HUMAN (1442-2307): 3.63e-161: 538: 23.25		OSBL9_HUMAN (209-743): 5.35e-159: 484: 30.32
+	Hs
		665524 EPHA8_HUMAN (1383-2242): 1.9e-173: 562: 18.61		OSBL2_HUMAN (323-758): 4.85e-138: 421: 23.19
+	Hs
		435750 IGF1R_HUMAN (1442-2307): 3.63e-161: 538: 23.25		OSB11_HUMAN (345-749): 6.21e-130: 409: 29.62