Protein: TRI65
E3 ubiquitin-protein ligase TRIM65 (EC 2.3.2.27) (Tripartite motif-containing protein 65)

Gene: TRI65, TRIM65
Organism: Homo sapiens
Interactions: 75
UniProt ID: Q6PJ69

Gene Ontology (top 5):
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0008270 - zinc ion binding
GO:0010508 - positive regulation of autophagy

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1245059

IFIH1
Interferon-induced helicase C domain-containing protein 1

2

17

Small-scale

0.839

High

1093641

MKRN3
E3 ubiquitin-protein ligase makorin-3

1

3

High-throughput

0.698

High

1245058

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

6

High-throughput

0.698

High

1245041

CCNJL
Cyclin-J-like protein

3

2

High-throughput

0.667

High

1245065

UBE2Z
Ubiquitin-conjugating enzyme E2 Z

1

20

High-throughput

0.656

High

345081

RIGI
Antiviral innate immune response receptor RIG-I

1

18

Small-scale

0.647

High

957762

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

20

Small-scale

0.647

High

982213

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

20

High-throughput

0.647

High

414049

P53
Cellular tumor antigen p53

3

7

Small-scale

0.646

High

488236

LOX5
Polyunsaturated fatty acid 5-lipoxygenase

2

3

High-throughput

0.628

High

1245064

DOCK5
Dedicator of cytokinesis protein 5

2

2

High-throughput

0.628

High

1245074

CRYL1
Lambda-crystallin homolog

2

3

High-throughput

0.628

High

1218721

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

20

High-throughput

0.625

High

970670

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

20

High-throughput

0.618

High

1245036

TRI67
Tripartite motif-containing protein 67

1

17

High-throughput

0.618

High

1245044

GALD1
Glutamine amidotransferase-like class 1 domain-containing protein 1

2

0

High-throughput

0.602

High

1245046

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

8

High-throughput

0.561

High

838940

RHG25
Rho GTPase-activating protein 25

2

6

High-throughput

0.558

High

1245054

SRPK1
SRSF protein kinase 1

1

8

High-throughput

0.550

High

1245068

APC11
Anaphase-promoting complex subunit 11

1

1

High-throughput

0.541

High

359830

DYR
Dihydrofolate reductase

1

1

High-throughput

0.536

High

1245042

CDK20
Cyclin-dependent kinase 20

1

7

High-throughput

0.536

High

1245051

EFMT3
EEF1A lysine methyltransferase 3

1

1

High-throughput

0.536

High

1245057

DUS16
Dual specificity protein phosphatase 16

1

5

High-throughput

0.536

High

1245062

SHRPN
Sharpin

1

4

High-throughput

0.536

High

1245066

MARH7
E3 ubiquitin-protein ligase MARCHF7

1

0

High-throughput

0.518

High

191344

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

1

0

High-throughput

0.513

High

349684

BPNT1
3'(2'),5'-bisphosphate nucleotidase 1

1

0

High-throughput

0.513

High

1245033

PLGT2
Protein O-glucosyltransferase 2

1

0

High-throughput

0.513

High

1245047

NPRL2
GATOR1 complex protein NPRL2

1

0

High-throughput

0.513

High

1245056

ISCA1
Iron-sulfur cluster assembly 1 homolog, mitochondrial

1

0

High-throughput

0.513

High

1245075

CDIN1
CDAN1-interacting nuclease 1

1

0

High-throughput

0.513

High

619838

VCAM1
Vascular cell adhesion protein 1

1

1

Small-scale

0.512

High

1050457

UBE3A
Ubiquitin-protein ligase E3A

1

7

High-throughput

0.508

High

1176997

INF2
Inverted formin-2

1

1

High-throughput

0.489

High

1200310

ANR39
Ankyrin repeat domain-containing protein 39

1

5

High-throughput

0.489

High

1245037

PK1L2
Polycystin-1-like protein 2

1

8

High-throughput

0.489

High

1245040

WDR5B
WD repeat-containing protein 5B

1

4

High-throughput

0.489

High

1245048

DNJB3
DnaJ homolog subfamily B member 3

1

3

High-throughput

0.489

High

1245055

NPAS1
Neuronal PAS domain-containing protein 1

1

3

High-throughput

0.489

High

181129

AXIN1
Axin-1

1

5

Small-scale

0.479

High

296054

IDHC
Isocitrate dehydrogenase [NADP] cytoplasmic

1

3

Small-scale

0.479

High

445925

ENOA
Alpha-enolase

1

2

Small-scale

0.479

High

848039

AL3B1
Aldehyde dehydrogenase family 3 member B1

1

1

High-throughput

0.479

High

962177

RHOA
Transforming protein RhoA

1

6

Small-scale

0.479

High

996211

EF1A1
Elongation factor 1-alpha 1

1

2

Small-scale

0.479

High

1113441

CUL3
Cullin-3

1

15

High-throughput

0.479

High

1128750

NBR1
Next to BRCA1 gene 1 protein

1

1

High-throughput

0.479

High

1140438

KIF14
Kinesin-like protein KIF14

1

17

High-throughput

0.479

High

1163841

DUS6
Dual specificity protein phosphatase 6

1

5

Small-scale

0.479

High

1245038

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

8

High-throughput

0.479

High

1245045

ARRD4
Arrestin domain-containing protein 4

1

4

Small-scale

0.479

High

1245049

KAT6A
Histone acetyltransferase KAT6A

1

4

Small-scale

0.479

High

1245053

NLRP3
NACHT, LRR and PYD domains-containing protein 3

1

20

Small-scale

0.479

High

1245060

NLRP1
NACHT, LRR and PYD domains-containing protein 1

1

20

Small-scale

0.479

High

1245061

KLHL4
Kelch-like protein 4

1

3

High-throughput

0.479

High

1245063

PKHA4
Pleckstrin homology domain-containing family A member 4

1

13

High-throughput

0.479

High

1245067

NLRC4
NLR family CARD domain-containing protein 4

1

20

Small-scale

0.479

High

1245072

TES
Testin

1

5

High-throughput

0.479

High

1245073

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

5

High-throughput

0.479

High

1135713

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

1245069

TMOD3
Tropomodulin-3

1

6

Small-scale

0.437

High

1185851

NSN5B
Putative NOL1/NOP2/Sun domain family member 5B

1

2

High-throughput

0.407

High

1245035

PKHG7
Pleckstrin homology domain-containing family G member 7

1

5

High-throughput

0.407

High

1245070

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

1

High-throughput

0.407

High

1245050

SNX21
Sorting nexin-21

2

0

High-throughput

0.328

High

1245071

CS025
UPF0449 protein C19orf25

2

0

High-throughput

0.313

High

999531

NOMO3
BOS complex subunit NOMO3

1

0

High-throughput

0.279

Low

1037069

OC90
Otoconin-90

1

0

High-throughput

0.279

Low

1169069

INSC
Protein inscuteable homolog

1

0

High-throughput

0.279

Low

1245034

LYPD4
Ly6/PLAUR domain-containing protein 4

1

0

High-throughput

0.279

Low

1245039

MGDP1
Magnesium-dependent phosphatase 1

1

0

High-throughput

0.249

Low

1245052

YI001
Uncharacterized protein FLJ30774

1

0

High-throughput

0.249

Low

933426

S12A2
Solute carrier family 12 member 2

1

0

High-throughput

0.232

Low

1245043

CI163
Uncharacterized protein C9orf163

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025