HitPredict - High confidence protein-protein interactions

Interactor 1: TOLL (P08953)
Protein toll
Gene: Tl

Interactor 2: TOLL (P08953)
Protein toll
Gene: Tl

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.902

Property	Details
Experiments	11881810, 23827685, 18347020, 15197269
Identification Methods	affinity chromatography technology, pull down, coimmunoprecipitation, solid phase assay
Interaction Type	physical association, direct interaction, covalent binding

Property	Details
Interacting Pfam domains	LRR_1~LRR_1, LRR_1~LRR_5, LRR_1~LRR_8, LRR_5~LRR_5, LRR_5~LRR_8, LRRNT~LRR_5, LRR_8~LRR_8, LRR_8~LRRCT, LRR_8~LRRNT, LRRNT~LRRNT, TIR_2~TIR_2
Common GO terms	GO:0002225 - positive regulation of antimicrobial peptide production GO:0002229 - defense response to oomycetes GO:0002347 - response to tumor cell GO:0002804 - positive regulation of antifungal peptide production GO:0004888 - transmembrane signaling receptor activity and 30 others more... GO:0004896 - cytokine receptor activity GO:0005769 - early endosome GO:0005886 - plasma membrane GO:0007155 - cell adhesion GO:0007416 - synapse assembly GO:0007507 - heart development GO:0007526 - larval somatic muscle development GO:0008063 - Toll signaling pathway GO:0009597 - detection of virus GO:0009611 - response to wounding GO:0009897 - external side of plasma membrane GO:0009950 - dorsal/ventral axis specification GO:0009986 - cell surface GO:0016201 - synaptic target inhibition GO:0019955 - cytokine binding GO:0030308 - negative regulation of cell growth GO:0032154 - cleavage furrow GO:0035208 - positive regulation of hemocyte proliferation GO:0035212 - cell competition in a multicellular organism GO:0038023 - signaling receptor activity GO:0040015 - negative regulation of multicellular organism growth GO:0045087 - innate immune response GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0046627 - negative regulation of insulin receptor signaling pathway GO:0046790 - virion binding GO:0050830 - defense response to Gram-positive bacterium GO:0061760 - antifungal innate immune response GO:0061809 - NAD+ nucleotidase, cyclic ADP-ribose generating GO:0070976 - TIR domain binding GO:1902875 - regulation of embryonic pattern specification
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1	1097
Dm

1	1097

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Last updated: 15 Jul 2024