HitPredict

Interactor 1: SNRPA (P09012)
U1 small nuclear ribonucleoprotein A (U1 snRNP A) (U1-A) (U1A)
Gene: SNRPA

Interactor 2: TRA2B (P62995)
Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B)
Gene: TRA2B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005681 - spliceosomal complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 282 Hs			1 288
+	Hs
		446619 SNRPA_HUMAN (1-282): 4.82e-60: 193: 100.00		TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06
+	Hs
		446810 SNRPA_HUMAN (1-282): 4.82e-60: 193: 100.00		RBM22_HUMAN (2-287): 6.71e-33: 126: 15.91
+	Hs
		441380 RU2B_HUMAN (5-282): 1.37e-59: 190: 46.40		RBM22_HUMAN (2-287): 6.71e-33: 126: 15.91
+	Hs
		446841 SNRPA_HUMAN (1-282): 4.82e-60: 193: 100.00		PPIE_HUMAN (118-201): 7.87e-27: 107: 36.91
+	Hs
		441393 RU2B_HUMAN (5-282): 1.37e-59: 190: 46.40		PPIE_HUMAN (118-201): 7.87e-27: 107: 36.91
+	Hs
		925044 RBY1F_HUMAN (1-280): 7.88e-46: 162: 17.48		TRA2B_HUMAN (1-267): 9.15e-34: 126: 100.00
+	Hs
		446592 SNRPA_HUMAN (1-282): 4.82e-60: 193: 100.00		TIAR_HUMAN (73-272): 5.47e-20: 90.6: 14.00
+	Hs
		446632 SNRPA_HUMAN (1-282): 4.82e-60: 193: 100.00		RBM39_HUMAN (15-248): 3.58e-18: 86.1: 21.83
+	Hs
		321252 PTBP3_HUMAN (2-281): 3.29e-49: 172: 19.44		PPIE_HUMAN (118-201): 7.87e-27: 107: 36.91
+	Hs
		446516 SNRPA_HUMAN (1-282): 4.82e-60: 193: 100.00		TIA1_HUMAN (113-248): 8.75e-18: 84.1: 18.42
+	Hs
		441283 RU2B_HUMAN (5-282): 1.37e-59: 190: 46.40		RBM39_HUMAN (15-248): 3.58e-18: 86.1: 21.83
+	Hs
		643504 PTBP1_HUMAN (1-281): 2.58e-55: 189: 20.42		RBM39_HUMAN (15-248): 3.58e-18: 86.1: 21.83
+	Hs
		321063 PTBP3_HUMAN (2-281): 3.29e-49: 172: 19.44		ELAV2_HUMAN (52-244): 6.85e-24: 101: 20.00
+	Hs
		321076 PTBP3_HUMAN (2-281): 3.29e-49: 172: 19.44		RBM39_HUMAN (15-248): 3.58e-18: 86.1: 21.83
+	Hs
		446628 SNRPA_HUMAN (1-282): 4.82e-60: 193: 100.00		HNRPD_HUMAN (106-178): 6.05e-11: 64: 26.03
+	Hs
		320990 PTBP3_HUMAN (2-281): 3.29e-49: 172: 19.44		TIA1_HUMAN (113-248): 8.75e-18: 84.1: 18.42
+	Hs
		446627 SNRPA_HUMAN (1-282): 4.82e-60: 193: 100.00		CIRBP_HUMAN (120-192): 7.93e-11: 61.6: 57.53
+	Sc
		376696 RU1A_YEAST (1-281): 3.81e-48: 163: 20.42		PABP_YEAST (98-206): 7.98e-20: 91.1: 19.27
+	Hs
		643501 PTBP1_HUMAN (1-281): 2.58e-55: 189: 20.42		HNRPD_HUMAN (106-178): 6.05e-11: 64: 26.03
+	Hs
		483438 RBY1A_HUMAN (1-280): 3.76e-46: 163: 17.48		CIRBP_HUMAN (120-192): 7.93e-11: 61.6: 57.53