HitPredict

Interactor 1: NPM (P06748)
Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin)
Gene: NPM1

Interactor 2: NUCL (P19338)
Nucleolin (Protein C23)
Gene: NCL

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.750

The method score is based on:

Property	Details
Experiments	8620867, 28514442, 33961781, 35271311, 39501047, 20431927, 16648475
Identification Methods	affinity chromatography technology, pull down, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005730 - nucleolus GO:0016020 - membrane and 2 others more... GO:0045944 - positive regulation of transcription by RNA polymerase II GO:1990904 - ribonucleoprotein complex
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1	294
Hs

1	710

Service provided by Combinatics, Japan

Last updated: 11Aug2025