Protein: NPM
Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin)

Gene: NPM, Npm1
Organism: Mus musculus
Interactions: 66
UniProt ID: Q61937

Gene Ontology (top 5):
GO:0000055 - ribosomal large subunit export from nucleus
GO:0000056 - ribosomal small subunit export from nucleus
GO:0001046 - core promoter sequence-specific DNA binding
GO:0001558 - regulation of cell growth
GO:0001652 - granular component

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1223422

NPM3
Nucleoplasmin-3

1

6

Small-scale

0.653

High

868935

RL5
Large ribosomal subunit protein uL18

2

2

Small-scale

0.584

High

1223419

FBXW7
F-box/WD repeat-containing protein 7

1

5

Small-scale

0.561

High

1223020

FXR1
RNA-binding protein FXR1

1

3

High-throughput

0.536

High

1021260

CDK2
Cyclin-dependent kinase 2

1

3

Small-scale

0.501

High

147805

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

2

High-throughput

0.479

High

266605

DHX9
ATP-dependent RNA helicase A

1

6

Small-scale

0.479

High

312576

PARP2
Poly [ADP-ribose] polymerase 2

1

2

Small-scale

0.479

High

373689

MYC
Myc proto-oncogene protein

1

5

Small-scale

0.479

High

382489

P53
Cellular tumor antigen p53

1

1

Small-scale

0.479

High

480974

NUCL
Nucleolin

1

3

Small-scale

0.479

High

570744

RL7
Large ribosomal subunit protein uL30

1

3

Small-scale

0.479

High

619298

RL13A
Large ribosomal subunit protein uL13

1

2

Small-scale

0.479

High

628501

VIME
Vimentin

1

1

Small-scale

0.479

High

700352

BRAF
Serine/threonine-protein kinase B-raf

1

5

High-throughput

0.479

High

877625

BRCA1
Breast cancer type 1 susceptibility protein homolog

1

7

Small-scale

0.479

High

881005

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

5

Small-scale

0.479

High

945964

EF2
Elongation factor 2

1

2

Small-scale

0.479

High

961459

RL27
Large ribosomal subunit protein eL27

1

2

Small-scale

0.479

High

967627

RS7
Small ribosomal subunit protein eS7

1

1

Small-scale

0.479

High

979393

RS6
Small ribosomal subunit protein eS6

1

2

Small-scale

0.479

High

985408

RS3
Small ribosomal subunit protein uS3

1

1

Small-scale

0.479

High

995518

RL22
Large ribosomal subunit protein eL22

1

2

Small-scale

0.479

High

1000181

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

1

6

Small-scale

0.479

High

1000203

ROCK2
Rho-associated protein kinase 2

1

4

Small-scale

0.479

High

1021208

RS3A
Small ribosomal subunit protein eS1

1

4

Small-scale

0.479

High

1021471

RS5
Small ribosomal subunit protein uS7

1

1

Small-scale

0.479

High

1021569

RGS14
Regulator of G-protein signaling 14

1

1

High-throughput

0.479

High

1044576

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

7

Small-scale

0.479

High

1180421

MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog

1

2

Small-scale

0.479

High

1193753

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

5

High-throughput

0.479

High

1223403

NUP62
Nuclear pore glycoprotein p62

1

2

Small-scale

0.479

High

1223404

TFE3
Transcription factor E3

1

3

High-throughput

0.479

High

1223408

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

3

Small-scale

0.479

High

1223411

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

4

Small-scale

0.479

High

1223413

FACD2
Fanconi anemia group D2 protein homolog

1

1

High-throughput

0.479

High

1223415

Q8BTS0
Probable ATP-dependent RNA helicase DDX5

1

1

Small-scale

0.479

High

1223420

DDX1
ATP-dependent RNA helicase DDX1

1

3

Small-scale

0.479

High

1223421

EED
Polycomb protein EED

1

9

High-throughput

0.479

High

1223423

CNTP2
Contactin-associated protein-like 2

1

1

High-throughput

0.479

High

1223425

RL4
Large ribosomal subunit protein uL4

1

2

Small-scale

0.479

High

1223426

NUP50
Nuclear pore complex protein Nup50

1

1

Small-scale

0.479

High

1223427

CAF1A
Chromatin assembly factor 1 subunit A

1

4

High-throughput

0.479

High

1223428

FZR1
Fizzy-related protein homolog

1

8

High-throughput

0.479

High

1223429

MECP2
Methyl-CpG-binding protein 2

1

3

Small-scale

0.479

High

586114

TFE2
Transcription factor E2-alpha

1

0

High-throughput

0.458

High

927800

ATX1
Ataxin-1

1

0

High-throughput

0.458

High

1188214

STING
Stimulator of interferon genes protein

1

0

High-throughput

0.458

High

1223405

ARF
Tumor suppressor ARF

1

0

Small-scale

0.458

High

1223406

BRSK2
Serine/threonine-protein kinase BRSK2

1

0

High-throughput

0.458

High

1223407

Q6GTZ3
Idb1 protein

1

0

Small-scale

0.458

High

1223409

NEB2
Neurabin-2

1

0

High-throughput

0.458

High

1223412

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.458

High

982601

RS15
Small ribosomal subunit protein uS19

1

2

Small-scale

0.457

High

986923

YBOX1
Y-box-binding protein 1

1

4

Small-scale

0.457

High

1223410

RS27
Small ribosomal subunit protein eS27

1

2

Small-scale

0.457

High

1223417

FTM
Protein fantom

1

6

High-throughput

0.445

High

104542

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

2

High-throughput

0.437

High

398473

CFAD
Complement factor D

1

3

High-throughput

0.437

High

595203

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

1

High-throughput

0.437

High

1223414

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

3

High-throughput

0.437

High

1223416

MT21E
Protein-lysine methyltransferase METTL21E

1

1

High-throughput

0.437

High

663104

GRIA2
Glutamate receptor 2

1

0

High-throughput

0.249

Low

1223418

FNDC5
Fibronectin type III domain-containing protein 5

1

0

High-throughput

0.249

Low

1223424

EBPL
Emopamil-binding protein-like

1

0

Small-scale

0.249

Low

1223373

GPAN1
G patch domain and ankyrin repeat-containing protein 1

1

0

Small-scale

0.238

Low


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Last updated: 11Aug2025