HitPredict

Interactor 1: NPM (P06748)
Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin)
Gene: NPM1

Interactor 2: AKT1 (P31749)
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)
Gene: AKT1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.629

The method score is based on:

Property	Details
Experiments	18931307, 35512704
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006606 - protein import into nucleus and 7 others more... GO:0007165 - signal transduction GO:0016020 - membrane GO:0019901 - protein kinase binding GO:0032991 - protein-containing complex GO:0042803 - protein homodimerization activity GO:0043066 - negative regulation of apoptotic process GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1	294
Hs

1	480

Service provided by Combinatics, Japan

Last updated: 11Aug2025