Protein: KS6A3
Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2)

Gene: KS6A3, RPS6KA3
Organism: Homo sapiens
Interactions: 192
UniProt ID: P51812

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0001501 - skeletal system development
GO:0002224 - toll-like receptor signaling pathway
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

703506

MK01
Mitogen-activated protein kinase 1

13

20

Small-scale

0.979

High

908093

CSK2B
Casein kinase II subunit beta

7

8

Small-scale

0.959

High

908115

KS6A1
Ribosomal protein S6 kinase alpha-1

6

15

High-throughput

0.949

High

908120

CDC37
Hsp90 co-chaperone Cdc37

5

14

High-throughput

0.919

High

541404

FGFR1
Fibroblast growth factor receptor 1

4

20

Small-scale

0.915

High

691684

MK03
Mitogen-activated protein kinase 3

5

20

Small-scale

0.912

High

641141

FGFR2
Fibroblast growth factor receptor 2

4

20

High-throughput

0.906

High

440452

FYN
Tyrosine-protein kinase Fyn

4

19

Small-scale

0.896

High

908114

KS6A2
Ribosomal protein S6 kinase alpha-2

4

15

High-throughput

0.892

High

270786

ROCK2
Rho-associated protein kinase 2

3

10

High-throughput

0.871

High

908104

GRSF1
G-rich sequence factor 1

3

12

High-throughput

0.861

High

461291

HS90A
Heat shock protein HSP 90-alpha

3

20

High-throughput

0.817

High

468200

HS90B
Heat shock protein HSP 90-beta

3

20

High-throughput

0.817

High

908113

PEA15
Astrocytic phosphoprotein PEA-15

2

1

Small-scale

0.812

High

241147

PRKN
E3 ubiquitin-protein ligase parkin

2

13

High-throughput

0.754

High

363003

EGFR
Epidermal growth factor receptor

2

19

High-throughput

0.754

High

485004

ROA1
Heterogeneous nuclear ribonucleoprotein A1

2

10

High-throughput

0.737

High

531022

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

10

High-throughput

0.737

High

620219

NUCL
Nucleolin

2

7

High-throughput

0.737

High

650653

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

2

11

High-throughput

0.737

High

908081

HNRPM
Heterogeneous nuclear ribonucleoprotein M

2

8

High-throughput

0.737

High

908094

CSK21
Casein kinase II subunit alpha

2

20

High-throughput

0.737

High

908116

SF3B4
Splicing factor 3B subunit 4

2

7

High-throughput

0.737

High

908125

RA1L2
Heterogeneous nuclear ribonucleoprotein A1-like 2

2

11

High-throughput

0.737

High

908144

CSK23
Casein kinase II subunit alpha 3

2

15

High-throughput

0.737

High

908121

AMHR2
Anti-Muellerian hormone type-2 receptor

1

4

High-throughput

0.691

High

908169

STRAB
STE20-related kinase adapter protein beta

1

14

High-throughput

0.691

High

167240

KLF11
Krueppel-like factor 11

1

5

High-throughput

0.665

High

856597

BAG6
Large proline-rich protein BAG6

1

9

High-throughput

0.665

High

908175

NEK6
Serine/threonine-protein kinase Nek6

1

16

High-throughput

0.665

High

557185

SRC
Proto-oncogene tyrosine-protein kinase Src

1

19

Small-scale

0.647

High

650095

FGFR3
Fibroblast growth factor receptor 3

1

20

Small-scale

0.647

High

683412

IKBA
NF-kappa-B inhibitor alpha

1

8

Small-scale

0.647

High

908171

ILKAP
Integrin-linked kinase-associated serine/threonine phosphatase 2C

1

5

Small-scale

0.647

High

463929

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

High-throughput

0.646

High

908095

H31
Histone H3.1

3

14

Small-scale

0.641

High

908146

PDC6I
Programmed cell death 6-interacting protein

2

12

High-throughput

0.628

High

908157

TRI11
E3 ubiquitin-protein ligase TRIM11

2

3

High-throughput

0.628

High

908136

SPRE2
Sprouty-related, EVH1 domain-containing protein 2

2

7

High-throughput

0.621

High

193534

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

20

Small-scale

0.618

High

375309

RASK
GTPase KRas

1

8

High-throughput

0.618

High

400514

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

High-throughput

0.618

High

411615

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

625257

CSK22
Casein kinase II subunit alpha'

1

19

High-throughput

0.618

High

648468

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.618

High

830380

CCNF
Cyclin-F

1

6

High-throughput

0.618

High

908080

KS6A3
Ribosomal protein S6 kinase alpha-3

1

15

High-throughput

0.618

High

908091

RAC1
Ras-related C3 botulinum toxin substrate 1

1

11

High-throughput

0.618

High

908109

SNTB2
Beta-2-syntrophin

1

17

High-throughput

0.618

High

908111

SCRIB
Protein scribble homolog

1

7

High-throughput

0.618

High

908119

MK14
Mitogen-activated protein kinase 14

1

20

Small-scale

0.618

High

908132

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.618

High

908139

MAPK5
MAP kinase-activated protein kinase 5

1

17

High-throughput

0.618

High

908161

RHOV
Rho-related GTP-binding protein RhoV

1

12

High-throughput

0.618

High

908172

RHOJ
Rho-related GTP-binding protein RhoJ

1

11

High-throughput

0.618

High

908173

PKHA4
Pleckstrin homology domain-containing family A member 4

1

15

High-throughput

0.618

High

908180

ARHGC
Rho guanine nucleotide exchange factor 12

2

8

High-throughput

0.611

High

908138

MISP
Mitotic interactor and substrate of PLK1

3

2

High-throughput

0.604

High

908159

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.602

High

701447

5HT2A
5-hydroxytryptamine receptor 2A

1

2

Small-scale

0.590

High

908182

TRM9B
Probable tRNA methyltransferase 9B

2

0

High-throughput

0.585

High

908084

BCAR1
Breast cancer anti-estrogen resistance protein 1

2

7

High-throughput

0.584

High

908112

P2RY6
P2Y purinoceptor 6

1

0

High-throughput

0.578

High

908126

H90B2
Putative heat shock protein HSP 90-beta 2

1

20

High-throughput

0.575

High

908127

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

11

High-throughput

0.575

High

346911

BAG2
BAG family molecular chaperone regulator 2

2

3

High-throughput

0.571

High

415445

HSPB1
Heat shock protein beta-1

2

5

High-throughput

0.571

High

446787

NPM
Nucleophosmin

2

2

High-throughput

0.571

High

449691

H2B1J
Histone H2B type 1-J

2

20

High-throughput

0.571

High

534810

BIP
Endoplasmic reticulum chaperone BiP

2

14

High-throughput

0.571

High

536789

HSP7C
Heat shock cognate 71 kDa protein

2

7

High-throughput

0.571

High

600775

HSP76
Heat shock 70 kDa protein 6

2

7

High-throughput

0.571

High

659874

H2B1O
Histone H2B type 1-O

2

20

High-throughput

0.571

High

754768

H2B1B
Histone H2B type 1-B

2

20

High-throughput

0.571

High

801232

HSPA9
Stress-70 protein, mitochondrial

2

18

High-throughput

0.571

High

908090

H4
Histone H4

2

2

High-throughput

0.571

High

908096

H33
Histone H3.3

2

14

High-throughput

0.571

High

908098

HNRPU
Heterogeneous nuclear ribonucleoprotein U

2

6

High-throughput

0.571

High

908103

RBBP4
Histone-binding protein RBBP4

2

6

High-throughput

0.571

High

908122

H31T
Histone H3.1t

2

14

High-throughput

0.571

High

908123

H2B2E
Histone H2B type 2-E

2

20

High-throughput

0.571

High

908129

H3C
Histone H3.3C

2

14

High-throughput

0.571

High

908133

H32
Histone H3.2

2

14

High-throughput

0.571

High

908147

HS105
Heat shock protein 105 kDa

2

15

High-throughput

0.571

High

908152

H2A1C
Histone H2A type 1-C

2

8

High-throughput

0.571

High

839210

MTOR
Serine/threonine-protein kinase mTOR

1

20

Small-scale

0.568

High

908184

ZMYM5
Zinc finger MYM-type protein 5

2

1

High-throughput

0.558

High

908108

PLD1
Phospholipase D1

1

1

Small-scale

0.553

High

529382

TAU
Microtubule-associated protein tau

1

13

Small-scale

0.550

High

601603

HMGA1
High mobility group protein HMG-I/HMG-Y

2

0

High-throughput

0.547

High

908085

PRPS1
Ribose-phosphate pyrophosphokinase 1

2

0

High-throughput

0.547

High

908141

CCAR2
Cell cycle and apoptosis regulator protein 2

2

0

High-throughput

0.547

High

162811

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

1

20

High-throughput

0.536

High

273654

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

1

4

High-throughput

0.536

High

908100

APBA1
Amyloid-beta A4 precursor protein-binding family A member 1

1

7

High-throughput

0.536

High

908143

SERB1
SERPINE1 mRNA-binding protein 1

1

3

High-throughput

0.536

High

908151

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

7

High-throughput

0.536

High

908153

EFMT3
EEF1A lysine methyltransferase 3

1

6

High-throughput

0.536

High

908155

ASTRA
Protein Aster-A

1

2

High-throughput

0.536

High

908170

NDEL1
Nuclear distribution protein nudE-like 1

1

4

High-throughput

0.536

High

418892

H2A1B
Histone H2A type 1-B/E

2

8

High-throughput

0.521

High

521595

H14
Histone H1.4

2

3

High-throughput

0.521

High

595713

H13
Histone H1.3

2

3

High-throughput

0.521

High

908134

H2A3
Histone H2A type 3

2

8

High-throughput

0.521

High

908160

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

2

1

High-throughput

0.521

High

395724

ESR1
Estrogen receptor

1

20

Small-scale

0.515

High

482592

GNAO
Guanine nucleotide-binding protein G(o) subunit alpha

1

4

High-throughput

0.515

High

699657

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

9

High-throughput

0.515

High

877455

MASP1
Mannan-binding lectin serine protease 1

1

6

High-throughput

0.508

High

908164

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

7

High-throughput

0.508

High

254094

CTND1
Catenin delta-1

1

7

High-throughput

0.501

High

413448

P53
Cellular tumor antigen p53

1

5

Small-scale

0.501

High

424373

HMGN1
Non-histone chromosomal protein HMG-14

1

2

Small-scale

0.501

High

591547

H2AX
Histone H2AX

1

8

Small-scale

0.501

High

827711

STAT3
Signal transducer and activator of transcription 3

1

2

Small-scale

0.501

High

861526

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

17

High-throughput

0.501

High

908088

SUMO2
Small ubiquitin-related modifier 2

1

1

High-throughput

0.501

High

908092

YBOX1
Y-box-binding protein 1

1

6

Small-scale

0.501

High

908106

ATM
Serine-protein kinase ATM

1

20

Small-scale

0.501

High

908140

RPTOR
Regulatory-associated protein of mTOR

1

12

Small-scale

0.501

High

908167

LST8
Target of rapamycin complex subunit LST8

1

3

Small-scale

0.501

High

908187

FBX7
F-box only protein 7

1

3

High-throughput

0.501

High

908097

IDD
Integral membrane protein DGCR2/IDD

1

3

High-throughput

0.489

High

908117

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

20

High-throughput

0.489

High

908128

IIGP5
Interferon-inducible GTPase 5

1

2

High-throughput

0.489

High

908158

I17RA
Interleukin-17 receptor A

1

3

High-throughput

0.489

High

908188

ADA18
Disintegrin and metalloproteinase domain-containing protein 18

1

1

High-throughput

0.489

High

908082

SPSY
Spermine synthase

1

0

High-throughput

0.486

High

124906

GTPB1
GTP-binding protein 1

1

7

High-throughput

0.479

High

317816

LTN1
E3 ubiquitin-protein ligase listerin

1

3

High-throughput

0.479

High

323688

AP2A2
AP-2 complex subunit alpha-2

1

3

High-throughput

0.479

High

340855

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

8

Small-scale

0.479

High

550931

PCNA
Proliferating cell nuclear antigen

1

2

High-throughput

0.479

High

588253

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.479

High

606461

CEBPB
CCAAT/enhancer-binding protein beta

1

2

High-throughput

0.479

High

648113

NDKB
Nucleoside diphosphate kinase B

1

2

High-throughput

0.479

High

659410

CRCM
Colorectal mutant cancer protein

1

8

High-throughput

0.479

High

683977

PTN3
Tyrosine-protein phosphatase non-receptor type 3

1

5

High-throughput

0.479

High

687166

HMGB2
High mobility group protein B2

1

9

High-throughput

0.479

High

690846

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

694977

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

8

High-throughput

0.479

High

720972

CLIP1
CAP-Gly domain-containing linker protein 1

1

17

High-throughput

0.479

High

729693

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.479

High

733753

FOXN2
Forkhead box protein N2

1

1

Small-scale

0.479

High

767747

RFA3
Replication protein A 14 kDa subunit

1

7

High-throughput

0.479

High

878809

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

9

High-throughput

0.479

High

908086

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

2

High-throughput

0.479

High

908089

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

908099

MDM2
E3 ubiquitin-protein ligase Mdm2

1

5

Small-scale

0.479

High

908101

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

908105

TRAF2
TNF receptor-associated factor 2

1

14

Small-scale

0.479

High

908107

CTBP1
C-terminal-binding protein 1

1

5

High-throughput

0.479

High

908110

PICAL
Phosphatidylinositol-binding clathrin assembly protein

1

3

High-throughput

0.479

High

908118

EZH2
Histone-lysine N-methyltransferase EZH2

1

7

High-throughput

0.479

High

908124

WASC4
WASH complex subunit 4

1

2

High-throughput

0.479

High

908142

DOCK4
Dedicator of cytokinesis protein 4

1

6

High-throughput

0.479

High

908145

FRS2
Fibroblast growth factor receptor substrate 2

1

2

High-throughput

0.479

High

908148

HDAC2
Histone deacetylase 2

1

9

High-throughput

0.479

High

908149

CBP
CREB-binding protein

1

13

Small-scale

0.479

High

908150

CSN5
COP9 signalosome complex subunit 5

1

6

High-throughput

0.479

High

908156

AP2M1
AP-2 complex subunit mu

1

5

High-throughput

0.479

High

908162

SNX27
Sorting nexin-27

1

20

High-throughput

0.479

High

908168

KLHL4
Kelch-like protein 4

1

5

High-throughput

0.479

High

908176

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

20

High-throughput

0.479

High

908177

DCP1A
mRNA-decapping enzyme 1A

1

1

High-throughput

0.479

High

908179

GTSE1
G2 and S phase-expressed protein 1

1

2

High-throughput

0.479

High

908181

AKA7G
A-kinase anchor protein 7 isoform gamma

1

5

High-throughput

0.479

High

908183

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

908189

UTP18
U3 small nucleolar RNA-associated protein 18 homolog

1

2

High-throughput

0.479

High

908174

BARX1
Homeobox protein BarH-like 1

1

2

High-throughput

0.464

High

837470

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

908087

RL37
Large ribosomal subunit protein eL37

1

0

High-throughput

0.458

High

908186

GSTK1
Glutathione S-transferase kappa 1

1

0

High-throughput

0.458

High

908102

B2CL1
Bcl-2-like protein 1

1

4

High-throughput

0.445

High

755470

ERD22
ER lumen protein-retaining receptor 2

1

2

High-throughput

0.437

High

908131

GBP6
Guanylate-binding protein 6

1

3

High-throughput

0.437

High

908135

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.437

High

908165

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

2

High-throughput

0.437

High

908166

LMF2
Lipase maturation factor 2

1

1

High-throughput

0.437

High

908178

TMPS4
Transmembrane protease serine 4

1

2

High-throughput

0.437

High

908185

GGA2
ADP-ribosylation factor-binding protein GGA2

1

4

High-throughput

0.437

High

516897

ECE2
Endothelin-converting enzyme 2

1

3

High-throughput

0.407

High

877649

SL9A3
Sodium/hydrogen exchanger 3

1

2

High-throughput

0.407

High

908137

TM139
Transmembrane protein 139

3

0

High-throughput

0.347

High

402346

GBA1
Lysosomal acid glucosylceramidase

1

0

High-throughput

0.279

Low

879996

DNSL1
Deoxyribonuclease-1-like 1

1

0

High-throughput

0.279

Low

908083

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

0

High-throughput

0.279

Low

908154

ARK2N
Protein ARK2N

1

0

High-throughput

0.279

Low

908130

PBIR3
PABIR family member 1

1

0

High-throughput

0.268

Low

617492

ATP5J
ATP synthase peripheral stalk subunit F6, mitochondrial

1

0

High-throughput

0.265

Low

908163

SFXN2
Sideroflexin-2

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025